Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil

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2014xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br/handle/iec/1013xmlui.dri2xhtml.METS-1.0.item-author
Nunes, Márcio Roberto Teixeira
Palacios, Gustavo
Faria, Nuno Rodrigues
Sousa Junior, Edivaldo Costa
Pantoja, Jamilla A
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Baele, Guy
Suchard, Marc A
Lemey, Philippe
Vasconcelos, Pedro Fernando da Costa
Lipkin, W. Ian
xmlui.dri2xhtml.METS-1.0.item-abstract
Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
xmlui.dri2xhtml.METS-1.0.item-citation
NUNES, Márcio Roberto Teixeira et al. Air travel is associated with intracontinental spread of dengue virus serotypes 1-3 in Brazil. Plos Neglected Tropical Diseases, v. 8, n. 4, p. 1-13, Apr. 2014xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Vírus da Dengue / isolamento & purificaçãoEstruturas Genéticas