Clinical and immunological profiles of anaemia in children and adolescents with Plasmodium vivax malaria in the Pará state, Brazilian Amazon
Children and adolescents are at great risk for developing iron deficiency anaemia worldwide. In the tropical areas, malaria and intestinal parasites may also play an important role in anaemia pathogenesis. This study aimed ...
Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)
The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ...
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases
Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...
First isolation of West Nile virus in Brazil
(Instituto Oswaldo Cruz, 2019)
BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought ...
Instituto Evandro Chagas: ciência e tecnologia a serviço da vigilância em saúde pública
(MS/ Secretaria de Vigilância Em Saúde, 2019)
Prenatal disorders and congenital Zika syndrome in squirrel monkeys
(Nature Research, 2021)
During the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this ...
Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys
(Nature Research, 2021)
The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...
Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika Virus
Zika virus (ZIKV) is a single-stranded positive-sense RNA flavivirus that possesses a genome approximately 10.7 Kb in length. Although pro-inflammatory and anti-inflammatory cytokines and apoptotic markers belonging to the ...