Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
(Dove Medical Press, 2019)
Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ...
Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)
The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ...
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases
Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...
The innate immune response in Zika virus infection
Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes ...
Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys
(Nature Research, 2021)
The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...