Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions
Background: Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages ...
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
(Dove Medical Press, 2019)
Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ...
Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)
The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ...
Endoplasmic reticulum stress markers and their possible implications in leprosy's pathogenesis
(Hindawi Publishing Corporation, 2018)
Mycobacterium leprae causes leprosy, a dermatoneurological disease which affects the skin and peripheral nerves. One of several cellular structures affected during M. leprae infection is the endoplasmic reticulum (ER). ...
Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys
(Nature Research, 2021)
The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...