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dc.contributor.authorCassiano, Gustavo Capatti-
dc.contributor.authorFurini, Adriana A. C-
dc.contributor.authorCapobianco, Marcela Petrolini-
dc.contributor.authorStorti-Melo, Luciane M-
dc.contributor.authorCunha, Maristela G-
dc.contributor.authorKano, Flora S-
dc.contributor.authorCarvalho, Luzia H-
dc.contributor.authorSoares, Irene S-
dc.contributor.authorSantos, Sidney E-
dc.contributor.authorPóvoa, Marinete Marins-
dc.contributor.authorMachado, Ricardo Luiz Dantas-
dc.date.accessioned2017-03-24T11:53:20Z-
dc.date.available2017-03-24T11:53:20Z-
dc.date.issued2016pt_BR
dc.identifier.citationCASSIANO, Gustavo Capattiet. Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against bloodûstage proteins of Plasmodium vivax. PLoS ONE, v. 11, n. 2, p. 1-9, Feb. 2016.pt_BR
dc.identifier.issn1932-6203-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/2427-
dc.description.abstractThe development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871CT was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1CT was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057GA. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines.pt_BR
dc.format.mimetypeapplication/pdfpt_BR
dc.languageengpt_BR
dc.publisherPublic Library of Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.titlePolymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against bloodûstage proteins of Plasmodium vivaxpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryMalária Vivax / imunologiapt_BR
dc.subject.decsPrimaryPlasmodium vivax / genéticapt_BR
dc.subject.decsPrimaryLinfócitos Bpt_BR
dc.subject.decsPrimaryGenótipopt_BR
dc.subject.decsPrimaryFormação de Anticorpospt_BR
dc.subject.decsPrimaryPolimorfismo de Nucleotídeo Únicopt_BR
dc.subject.decsPrimaryReação em Cadeia da Polimerase / métodospt_BR
dc.creator.affilliationSão Paulo State University. Department of Biology. São José do Rio Preto, SP, Brazil.pt_BR
dc.creator.affilliationCollege of Medicine of São José do Rio Preto. Department of Dermatologic, Infectious, and Parasitic Diseases. São José do Rio Preto, SP, Brazil.pt_BR
dc.creator.affilliationSão Paulo State University. Department of Biology. São José do Rio Preto, SP, Brazil.pt_BR
dc.creator.affilliationFederal University of Sergipe. Department of Biology. Aracaju, SE, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Institute of Biological Sciences. Laboratório of Microbiology and Immunology. Belém, PA, Brazil.pt_BR
dc.creator.affilliationOswaldo Cruz Foundation. Laboratory of Malaria, René Rachou Research Center. Belo Horizonte, MG, Brazil.pt_BR
dc.creator.affilliationOswaldo Cruz Foundation. Laboratory of Malaria, René Rachou Research Center. Belo Horizonte, MG, Brazil.pt_BR
dc.creator.affilliationUniversity of São Paulo. Faculty of Pharmaceutical Sciences. Department of Clinical and Toxicological Analyses. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationFederal University of Pará. Laboratory of Human and Medical Genetics. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Pesquisa Básica em Malária. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Pesquisa Básica em Malária. Ananindeua, PA, Brasil / São Paulo State University. Department of Biology. São José do Rio Preto, SP, Brazil.pt_BR
dc.identifier.doi10.1371/journal.pone.0149581-


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