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Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against bloodûstage proteins of Plasmodium vivax
dc.contributor.author | Cassiano, Gustavo Capatti | - |
dc.contributor.author | Furini, Adriana A. C | - |
dc.contributor.author | Capobianco, Marcela Petrolini | - |
dc.contributor.author | Storti-Melo, Luciane M | - |
dc.contributor.author | Cunha, Maristela G | - |
dc.contributor.author | Kano, Flora S | - |
dc.contributor.author | Carvalho, Luzia H | - |
dc.contributor.author | Soares, Irene S | - |
dc.contributor.author | Santos, Sidney E | - |
dc.contributor.author | Póvoa, Marinete Marins | - |
dc.contributor.author | Machado, Ricardo Luiz Dantas | - |
dc.date.accessioned | 2017-03-24T11:53:20Z | - |
dc.date.available | 2017-03-24T11:53:20Z | - |
dc.date.issued | 2016 | pt_BR |
dc.identifier.citation | CASSIANO, Gustavo Capattiet. Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against bloodûstage proteins of Plasmodium vivax. PLoS ONE, v. 11, n. 2, p. 1-9, Feb. 2016. | pt_BR |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://patua.iec.gov.br/handle/iec/2427 | - |
dc.description.abstract | The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871CT was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1CT was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057GA. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines. | pt_BR |
dc.format.mimetype | application/pdf | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Public Library of Science | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.title | Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against bloodûstage proteins of Plasmodium vivax | pt_BR |
dc.type | Artigo | pt_BR |
dc.subject.decsPrimary | Malária Vivax / imunologia | pt_BR |
dc.subject.decsPrimary | Plasmodium vivax / genética | pt_BR |
dc.subject.decsPrimary | Linfócitos B | pt_BR |
dc.subject.decsPrimary | Genótipo | pt_BR |
dc.subject.decsPrimary | Formação de Anticorpos | pt_BR |
dc.subject.decsPrimary | Polimorfismo de Nucleotídeo Único | pt_BR |
dc.subject.decsPrimary | Reação em Cadeia da Polimerase / métodos | pt_BR |
dc.creator.affilliation | São Paulo State University. Department of Biology. São José do Rio Preto, SP, Brazil. | pt_BR |
dc.creator.affilliation | College of Medicine of São José do Rio Preto. Department of Dermatologic, Infectious, and Parasitic Diseases. São José do Rio Preto, SP, Brazil. | pt_BR |
dc.creator.affilliation | São Paulo State University. Department of Biology. São José do Rio Preto, SP, Brazil. | pt_BR |
dc.creator.affilliation | Federal University of Sergipe. Department of Biology. Aracaju, SE, Brazil. | pt_BR |
dc.creator.affilliation | Federal University of Pará. Institute of Biological Sciences. Laboratório of Microbiology and Immunology. Belém, PA, Brazil. | pt_BR |
dc.creator.affilliation | Oswaldo Cruz Foundation. Laboratory of Malaria, René Rachou Research Center. Belo Horizonte, MG, Brazil. | pt_BR |
dc.creator.affilliation | Oswaldo Cruz Foundation. Laboratory of Malaria, René Rachou Research Center. Belo Horizonte, MG, Brazil. | pt_BR |
dc.creator.affilliation | University of São Paulo. Faculty of Pharmaceutical Sciences. Department of Clinical and Toxicological Analyses. São Paulo, SP, Brazil. | pt_BR |
dc.creator.affilliation | Federal University of Pará. Laboratory of Human and Medical Genetics. Belém, PA, Brazil. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Pesquisa Básica em Malária. Ananindeua, PA, Brasil. | pt_BR |
dc.creator.affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Pesquisa Básica em Malária. Ananindeua, PA, Brasil / São Paulo State University. Department of Biology. São José do Rio Preto, SP, Brazil. | pt_BR |
dc.identifier.doi | 10.1371/journal.pone.0149581 | - |