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Booster dose after 10 years is recommended following 17DD-YF primary vaccination

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2016
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Booster dose after 10 years is recommended following 17DD-YF primary vaccination.pdf (982.7xmlui.dri2xhtml.METS-1.0.size-kilobytes)
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http://patua.iec.gov.br/handle/iec/2437
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Azevedo, Ana Carolina Campi
Pereira, Christian Costa
Antonelli, Lis Ribeiro do Valle
Fonseca, Cristina T
Carvalho, Andréa Teixeira
Rezende, Gabriela Villela
Santos, Raiany A
Batista, Maurício A
Campos, Fernanda M
Porto, Luiza Pacheco
Melo Júnior, Otoni A
Hossell, Débora MSH
Reis, Jordana G. Coelho dos
Magalhães, Vanessa Peruhype
Silva, Matheus F. Costa
Oliveira, Jaquelline G. de
Farias, Roberto H
Noronha, Tatiana G
Lemos, Jandira A
Von Doellinger, Vanessa dos R
Simões, Marisol
Souza, Mirian M de
Malaquias, Luiz C
Persi, Harold R
Pereira, Jorge M
Martins, José A
Ribeiro, Marcos Dornelas
Vinhas, Aline de A
Alves, Tatiane R
Maia, Maria de L
Freire, Marcos da S
Martins, Reinaldo de M
Homma, Akira
Romano, Alessandro PM
Domingues, Carla M
Tauil, Pedro L
Vasconcelos, Pedro Fernando da Costa
Rios, Maria
Caldas, Iramaya R
Camacho, Luiz A
Martins Filho, Olindo Assis
xmlui.dri2xhtml.METS-1.0.item-abstract
A single vaccination of Yellow Fever vaccines is believed to confer life-long protection. In this study, results of vaccinees who received a single dose of 17DD-YF immunization followed over 10 y challenge this premise. YF-neutralizing antibodies, subsets of memory T and B cells as well as cytokine-producing lymphocytes were evaluated in groups of adults before (NVday0) and after (PVday30-45, PVyear1-4, PVyear5-9, PVyear10-11, PVyear12-13) 17DD-YF primary vaccination. YF-neutralizing antibodies decrease significantly from PVyear1-4 to PVyear12-13 as compared to PVday30-45, and the seropositivity rates (PRNT≥2.9Log10mIU/mL) become critical (lower than 90%) beyond PVyear5-9. YF-specific memory phenotypes (effector T-cells and classical B-cells) significantly increase at PVday30-45 as compared to na've baseline. Moreover, these phenotypes tend to decrease at PVyear10-11 as compared to PVday30-45. Decreasing levels of TNF-α(+) and IFN-γ(+) produced by CD4(+) and CD8(+) T-cells along with increasing levels of IL-10(+)CD4(+)T-cells were characteristic of anti-YF response over time. Systems biology profiling represented by hierarchic networks revealed that while the na've baseline is characterized by independent micro-nets, primary vaccinees displayed an imbricate network with essential role of central and effector CD8(+) memory T-cell responses. Any putative limitations of this cross-sectional study will certainly be answered by the ongoing longitudinal population-based investigation. Overall, our data support the current Brazilian national immunization policy guidelines that recommend one booster dose 10 y after primary 17DD-YF vaccination.
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AZEVEDO, Ana Carolina Campi et al. Booster dose after 10 years is recommended following 17DD-YF primary vaccination. Human Vaccines & Immunotherapeutics, v. 12, n. 2, p. 491-502, 2016
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Imunidade / imunologia
Imunização Secundária
Febre Amarela / imunologia
Febre Amarela / prevenção & controle
Vacina contra Febre Amarela / administração & dosagem
Vacina contra Febre Amarela / imunologia
Fatores de Tempo
Citometria de Fluxo / métodos
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br