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Chromosomes in a genome-wise order: evidence for metaphase architecture

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2016
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Chromosomes in a genome-wise order- evidence for metaphase architecture.pdf (2.627xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br/handle/iec/2452
xmlui.dri2xhtml.METS-1.0.item-author
Weise, Anja
Bhatt, Samarth
Piaszinski, Katja
Kosyakova, Nadezda
Fan, Xiaobo
Altendorf-Hofmann, Annelore
Tanomtong, Alongklod
Chaveerach, Arunrat
Cioffi, Marcelo Bello de
Oliveira, Edivaldo Herculano Correa de
Walther, Joachim-U
Liehr, Thomas
Chaudhuri, Jyoti P
xmlui.dri2xhtml.METS-1.0.item-abstract
Background: One fundamental finding of the last decade is that, besides the primary DNA sequence information there are several epigenetic ôinformation-layersö like DNA-and histone modifications, chromatin packaging and, last but not least, the position of genes in the nucleus. Results: We postulate that the functional genomic architecture is not restricted to the interphase of the cell cycle but can also be observed in the metaphase stage, when chromosomes are most condensed and microscopically visible. If so, it offers the unique opportunity to directly analyze the functional aspects of genomic architecture in different cells, species and diseases. Another aspect not directly accessible by molecular techniques is the genome merged from two different haploid parental genomes represented by the homologous chromosome sets. Our results show that there is not only a well-known and defined nuclear architecture in interphase but also in metaphase leading to a bilateral organization of the two haploid sets of chromosomes. Moreover, evidence is provided for the parental origin of the haploid grouping. Conclusions: From our findings we postulate an additional epigenetic information layer within the genome including the organization of homologous chromosomes and their parental origin which may now substantially change the landscape of genetics.
xmlui.dri2xhtml.METS-1.0.item-citation
WEISE, Anja et al. Chromosomes in a genome-wise order : evidence for metaphase architecture. Molecular Cytogenetics, v. 9, p. 1-11, Apr. 2016.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Hibridização Genética
Cromossomos / genética
Metáfase / genética
Haploidia
Hibridização In Situ Fluorescente / métodos
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  • SAMAM - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br