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dc.contributor.authorWeise, Anja-
dc.contributor.authorBhatt, Samarth-
dc.contributor.authorPiaszinski, Katja-
dc.contributor.authorKosyakova, Nadezda-
dc.contributor.authorFan, Xiaobo-
dc.contributor.authorAltendorf-Hofmann, Annelore-
dc.contributor.authorTanomtong, Alongklod-
dc.contributor.authorChaveerach, Arunrat-
dc.contributor.authorCioffi, Marcelo Bello de-
dc.contributor.authorOliveira, Edivaldo Herculano Correa de-
dc.contributor.authorWalther, Joachim-U-
dc.contributor.authorLiehr, Thomas-
dc.contributor.authorChaudhuri, Jyoti P-
dc.date.accessioned2017-01-31T13:53:29Z-
dc.date.available2017-01-31T13:53:29Z-
dc.date.issued2016-
dc.identifier.citationWEISE, Anja et al. Chromosomes in a genome-wise order : evidence for metaphase architecture. Molecular Cytogenetics, v. 9, p. 1-11, Apr. 2016.pt_BR
dc.identifier.issn1755-8166-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/2452-
dc.description.abstractBackground: One fundamental finding of the last decade is that, besides the primary DNA sequence information there are several epigenetic ôinformation-layersö like DNA-and histone modifications, chromatin packaging and, last but not least, the position of genes in the nucleus. Results: We postulate that the functional genomic architecture is not restricted to the interphase of the cell cycle but can also be observed in the metaphase stage, when chromosomes are most condensed and microscopically visible. If so, it offers the unique opportunity to directly analyze the functional aspects of genomic architecture in different cells, species and diseases. Another aspect not directly accessible by molecular techniques is the genome merged from two different haploid parental genomes represented by the homologous chromosome sets. Our results show that there is not only a well-known and defined nuclear architecture in interphase but also in metaphase leading to a bilateral organization of the two haploid sets of chromosomes. Moreover, evidence is provided for the parental origin of the haploid grouping. Conclusions: From our findings we postulate an additional epigenetic information layer within the genome including the organization of homologous chromosomes and their parental origin which may now substantially change the landscape of genetics.pt_BR
dc.format.mimetypeapplication/pdf-
dc.languageengpt_BR
dc.publisherBioMed Centralpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleChromosomes in a genome-wise order: evidence for metaphase architecturept_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryHibridização Genéticapt_BR
dc.subject.decsPrimaryCromossomos / genéticapt_BR
dc.subject.decsPrimaryMetáfase / genéticapt_BR
dc.subject.decsPrimaryHaploidiapt_BR
dc.subject.decsPrimaryHibridização In Situ Fluorescente / métodospt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germany.pt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germany.pt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germany.pt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germany.pt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germany.pt_BR
dc.creator.affilliationJena University Hospital. Department of General, Visceral und Vascular Surgery. Jena, Germany.pt_BR
dc.creator.affilliationKhon Kaen University. Faculty of Science. Department of Biology. Khon Kaen, Thailandpt_BR
dc.creator.affilliationKhon Kaen University. Faculty of Science. Department of Biology. Khon Kaen, Thailandpt_BR
dc.creator.affilliationUniversidade Federal de São Carlos. Departamento de Genética e Evolução. São Carlos, SP, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Cultura de Tecidos e Citogenética. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Cultura de Tecidos e Citogenética. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germanypt_BR
dc.creator.affilliationJena University Hospital. Institute of Human Genetics. Jena, Germany / Ludwig Maximillians Universität. Kinderklinik, Munich, Germany.pt_BR
dc.identifier.doi10.1186/s13039-016-0243-y-


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