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Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil

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2016
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Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil.pdf (1.759xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br/handle/iec/2471
xmlui.dri2xhtml.METS-1.0.item-author
Sousa, Rita Catarina Medeiros
Jusot, Viviane
Houillon, Guy
Rasuli, Anvar
Martorelli, Luzia
Kataoka, Ana Paula
Mechlia, Mohamed Ben
Le Guern, Anne-Sophie
Rodrigues, Liliam
Assef, Rhomero
Maestri, Alvino
Lima, Reynaldo
Rotivel, Yolande
Bosch-Castells, Valerie
Tordo, Noël
xmlui.dri2xhtml.METS-1.0.item-abstract
Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004-2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. Methodology/Principal Findings This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers <0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84 percent) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85-88.0 percent of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9 percent of the interviewed population) had received at least one dose of booster since their vaccination in 2005. Conclusions/Significance This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas.
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SOUSA, Rita Catarina Medeiros et al. Persistence of rabies virus-neutralizing antibodies after vaccination of rural population following vampire bat rabies outbreak in Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 9, 2016.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Raiva / epidemiologia
Vírus da Raiva / imunologia
Vacinas Antirrábicas / imunologia
Anticorpos Neutralizantes / imunologia
Imunização Secundária
População Rural
Estudos Prospectivos
Ecossistema Amazônico
Fatores de Tempo
Brasil (BR)
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  • SAVIR - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br