The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment

xmlui.dri2xhtml.METS-1.0.item-date
2016xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
xmlui.mirage2.itemSummaryView.MetaData
xmlui.ArtifactBrowser.ItemViewer.show_fullxmlui.dri2xhtml.METS-1.0.item-uri
http://patua.iec.gov.br/handle/iec/2502xmlui.dri2xhtml.METS-1.0.item-author
Sortica, Vinicius Albuquerque
Lindenau, Juliana D
Cunha, Maristela G
Ohnishi, Maria D. O
Ventura, Ana Maria Revoredo da Silva
Santos, Andrea Kely Campos Ribeiro dos
Santos, Sidney E. B
Guimarães, Luciano S. P
Hutz, Mara H
xmlui.dri2xhtml.METS-1.0.item-abstract
Background: Chloroquine/primaquine is the current therapy to eliminate Plasmodium vivax infection in the Amazon region. Aims: This study investigates CYP1A2, CYP2C8, CYP2C9, CYP3A4 and CYP3A5 genetic polymorphisms influence on cloroquine/primaquine treatment. Patients & methods: Generalized estimating equations analyses were performed to determine the genetic influence in parasitemia and/or gametocytemia clearance over treatment time in 164 patients. Results: An effect of CYP2C8 low-activity alleles on treatment was observed (p = 0.01). From baseline to first day of treatment, wild-type individuals achieved greater reduction of gametocytes than low-activity allele carriers. CYP2C9 and CYP3A5 genes showed a trend for gametocytemia and parasitemia clearance rates. Conclusion: Future studies should be performed to access the extent of CYP2C8, CYP2C9 and CYP3A5 gene polymorphisms influence on cloroquine/primaquine treatment.
xmlui.dri2xhtml.METS-1.0.item-citation
SORTICA, Vinicius A. et al. The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment. Pharmacogenomics. v. 17, n. 17, p. 1903-1911, Nov. 2016.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Malária / quimioterapiaMalária / terapia
CYP2C8
CYP2C9
CYP3A5
Farmacogenética
Cloroquina / uso terapêutico
Primaquina / uso terapêutico
Antimaláricos / uso terapêutico
Plasmodium vivax / efeitos de drogas
Polimorfismo Genético / genética
Parasitemia
Resultado do Tratamento
Ecossistema Amazônico
Brasil (BR)