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dc.contributor.authorSortica, Vinicius Albuquerque-
dc.contributor.authorLindenau, Juliana D-
dc.contributor.authorCunha, Maristela G-
dc.contributor.authorOhnishi, Maria D. O-
dc.contributor.authorVentura, Ana Maria Revoredo da Silva-
dc.contributor.authorSantos, Andrea Kely Campos Ribeiro dos-
dc.contributor.authorSantos, Sidney E. B-
dc.contributor.authorGuimarães, Luciano S. P-
dc.contributor.authorHutz, Mara H-
dc.date.accessioned2017-02-10T17:16:21Z-
dc.date.available2017-02-10T17:16:21Z-
dc.date.issued2016-
dc.identifier.citationSORTICA, Vinicius A. et al. The effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatment. Pharmacogenomics. v. 17, n. 17, p. 1903-1911, Nov. 2016.pt_BR
dc.identifier.issn1744-8042-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/2502-
dc.description.abstractBackground: Chloroquine/primaquine is the current therapy to eliminate Plasmodium vivax infection in the Amazon region. Aims: This study investigates CYP1A2, CYP2C8, CYP2C9, CYP3A4 and CYP3A5 genetic polymorphisms influence on cloroquine/primaquine treatment. Patients & methods: Generalized estimating equations analyses were performed to determine the genetic influence in parasitemia and/or gametocytemia clearance over treatment time in 164 patients. Results: An effect of CYP2C8 low-activity alleles on treatment was observed (p = 0.01). From baseline to first day of treatment, wild-type individuals achieved greater reduction of gametocytes than low-activity allele carriers. CYP2C9 and CYP3A5 genes showed a trend for gametocytemia and parasitemia clearance rates. Conclusion: Future studies should be performed to access the extent of CYP2C8, CYP2C9 and CYP3A5 gene polymorphisms influence on cloroquine/primaquine treatment.pt_BR
dc.description.sponsorshipThe authors thank the financial support provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil)pt_BR
dc.language.isoengpt_BR
dc.publisherFuture Medicinept_BR
dc.rightsAcesso Abertopt_BR
dc.titleThe effect of SNPs in CYP450 in chloroquine/primaquine Plasmodium vivax malaria treatmentpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryMalária / quimioterapiapt_BR
dc.subject.decsPrimaryMalária / terapiapt_BR
dc.subject.decsPrimaryCYP2C8pt_BR
dc.subject.decsPrimaryCYP2C9pt_BR
dc.subject.decsPrimaryCYP3A5pt_BR
dc.subject.decsPrimaryFarmacogenéticapt_BR
dc.subject.decsPrimaryCloroquina / uso terapêuticopt_BR
dc.subject.decsPrimaryPrimaquina / uso terapêuticopt_BR
dc.subject.decsPrimaryAntimaláricos / uso terapêuticopt_BR
dc.subject.decsPrimaryPlasmodium vivax / efeitos de drogaspt_BR
dc.subject.decsPrimaryPolimorfismo Genético / genéticapt_BR
dc.subject.decsPrimaryParasitemiapt_BR
dc.subject.decsPrimaryResultado do Tratamentopt_BR
dc.subject.decsPrimaryEcossistema Amazônicopt_BR
dc.subject.decsPrimaryBrasil (BR)pt_BR
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Pará. Laboratório de Microbiologia e Imunologia. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brazil.pt_BR
dc.creator.affilliationHospital de Clínicas de Porto Alegre.Grupo de Pesquisa e Pós Graduação. Unidade de Bioestatística. Porto Alegre, RS, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.pt_BR
dc.identifier.doi10.2217/pgs-2016-0131-


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