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dc.contributor.authorSiqueira, Camila Monteiro
dc.contributor.authorHomsani, Fortune
dc.contributor.authorVeiga, Venício Féo da
dc.contributor.authorLyrio, Carlos
dc.contributor.authorMattos, Haroldo José de
dc.contributor.authorPassos, Sonia Regina Lambert
dc.contributor.authorCouceiro, José Nelson
dc.contributor.authorQuaresma, Carla Holandino
dc.date.accessioned2017-02-14T11:27:47Z
dc.date.available2017-02-14T11:27:47Z
dc.date.issued2016
dc.identifier.citationSIQUEIRA, Camila Monteiro et al. Homeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trial. Homeopathy, v. 105, n. 1, p. 71-77, 2016.en_US
dc.identifier.issn1476-4245
dc.identifier.urihttp://dspace.iec.gov.br/handle/iec/2513
dc.description.sponsorshipFAPERJ; Instituto Roberto Costa; (CAPES)pt_BR
dc.language.isoengen_US
dc.publisherElsevierpt_BR
dc.rightsAcesso Restritopt_BR
dc.titleHomeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trialen_US
dc.typeArtigopt_BR
dc.date.iso20170214
dc.subject.decsPrimaryInfluenza Humanapt_BR
dc.subject.decsPrimaryVacinas contra Influenzapt_BR
dc.subject.decsPrimaryMedicamento Homeopáticopt_BR
dc.subject.decsPrimaryHomeopatiapt_BR
dc.subject.decsPrimaryEnsaio Clínicopt_BR
dc.subject.decsPrimarySistema Único de Saúdept_BR
dc.subject.decsPrimaryPetrópolis (RJ)pt_BR
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Medicamentos. Rio de Janeiro, RJ, Brazil / Instituto Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Medicamentos. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationInstituto Roberto Costa. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brazil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Medicamentos. Rio de Janeiro, RJ, Brazil.pt_BR
dc.description.abstractenBackground: Influenza and its complications are common at all ages, especially in children. Vaccines and anti-influenza drugs aim to prevent it. Preventative approaches with favorable risk profiles should be considered for flu, particularly since the evidence of the efficacy of anti-viral drugs is debated. Methods: This pragmatic clinical trial was conducted in the Brazilian Public Health System in Petrópolis (BPHSP) with children aged from 1 to 5 years old. The medications used were mainly selected based on in vitro experiments (InfluBio), and in successful qualitative clinical experiences (Homeopathic Complex). Following informed parental consent, subjects were randomly distributed, in a blind manner, to three experimental groups: Homeopathic Complex, Placebo, and InfluBio. BPHSP health agents collected flu and acute respiratory infection symptomatic episodes monthly following the established protocol. The number of these episodes was registered in one year (2009–2010). Results: Out of the 600 children recruited, 445 (74.17%) completed the study (149: Homeopathic complex; 151: Placebo; 145: InfluBio). The number of flu and acute respiratory infection symptomatic episodes detected in this clinical trial was low; however, it was different between homeopathic groups and placebo (p < 0.001). In the first year post-intervention, 46/151 (30.5%) of children in the placebo group developed 3 or more flu and acute respiratory infection episodes, while there was no episode in the group of 149 children who used Homeopathic Complex, and only 1 episode in the group of 145 (1%) children who received InfluBio. Conclusion: These results suggested that the use of homeopathic medicines minimized the number of flu and acute respiratory infection symptomatic episodes in children, signalizing that the homeopathic prophylactic potential should be investigated in further studies.en_US
dc.identifier.doi10.1016/j.homp.2015.02.006


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