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dc.contributor.authorGuerra, Sylvia Fátima Santos-
dc.contributor.authorSoares, Luana Silva-
dc.contributor.authorLobo, Patricia Santos-
dc.contributor.authorPenha Junior, Edvaldo Tavares-
dc.contributor.authorSousa Junior, Edivaldo Costa-
dc.contributor.authorBezerra, Delana Andreza Melo-
dc.contributor.authorVaz, Lívia Rodrigues-
dc.contributor.authorLinhares, Alexandre da Costa-
dc.contributor.authorMascarenhas, Joana D'Arc Pereira-
dc.date.accessioned2017-02-20T17:09:18Z-
dc.date.available2017-02-20T17:09:18Z-
dc.date.issued2016-
dc.identifier.citationGUERRA, Sylvia Fátima Santos et al. Detection of a novel equine-like G3 rotavirus associated with acute gastroenteritis in Brazil. Journal of General Virology, v. 97, n. 12, p. 3131-3138, Dec. 2016pt_BR
dc.identifier.issn1465-2099-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/2529-
dc.description.abstractGenotype G3P[8] of rotavirus A (RVA) is detected worldwide, usually associated with Wa-like constellation and exhibiting a long RNA migration pattern. More recently, a novel inter-genogroup, G3P[8] reassortant variant with a short electropherotype, has emerged in Asia, Oceania and Europe, denoting an overall potential of unusual rotavirus strains. During a RVA surveillance in Brazil, G3P[8] strains were found displaying a short electropherotype pattern, which had not been detected before in this region. This study aims to characterize the complete genome of 10 G3P[8] strains detected in the northern region of Brazil. All G3P[8] samples were subjected to partial sequencing, and the whole-genome phylogenetic analysis demonstrated that all strains possessed I2-R2-C2-M2-A2-N1-T2-E2-H2 genotype background, representing reassortants with an equine-like G3 VP7 and amino acid changes in VP4 and VP7 antigenic regions as compared to vaccine strains. Phylogenetic analysis demonstrated high nucleotide identity in almost all RNA segments of G3P[8] DS-1 samples detected in Asia, Oceania and Europe as well as G3P[4] strains in Japan. This study reports a novel, equine-like G3P[8] strain circulating in Brazil and isolated from children hospitalized for severe gastroenteritis, and highlights the complex dynamics of RVA molecular epidemiology. Our findings point to a novel RVA strain emerging in this region, and studies should be done to detect whether this may represent a challenge to current vaccine strategies.pt_BR
dc.format.mimetypeapplication/pdf-
dc.languageengpt_BR
dc.publisherMicrobiology Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleDetection of a novel equine-like G3 rotavirus associated with acute gastroenteritis in Brazilpt_BR
dc.title.alternativeDetecção de um novo rotavírus G3 de tipo equino associado à gastroenterite aguda no Brasilpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryRotavirus / isolamento & purificaçãopt_BR
dc.subject.decsPrimaryRotavirus / genéticapt_BR
dc.subject.decsPrimaryGastroenterite / virologiapt_BR
dc.subject.decsPrimaryRNA Viral / genéticapt_BR
dc.subject.decsPrimaryVariação Genéticapt_BR
dc.subject.decsPrimaryFilogeniapt_BR
dc.subject.decsPrimaryGenótipopt_BR
dc.subject.decsPrimaryReação em Cadeia da Polimerase / métodospt_BR
dc.subject.decsPrimaryEcossistema Amazônicopt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.identifier.doi10.1099/jgv.0.000626-


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