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Polymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivax

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1992
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Polymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivax.pdf (683.6xmlui.dri2xhtml.METS-1.0.size-kilobytes)
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http://patua.iec.gov.br/handle/iec/2593
xmlui.dri2xhtml.METS-1.0.item-author
Qari, Shoukat H
Goldman, Ira F
Póvoa, Marinete Marins
Di Santi, Sylvia
Alpers, Michael P
Lal, Altaf A
xmlui.dri2xhtml.METS-1.0.item-abstract
The circumsporozoite (CS) protein that covers the surface of infectious sporozoites is a candidate antigen in malaria vaccine development. To determine the extent of B- and T-epitope polymorphism and to understand the mechanisms of antigenic variability, we have characterized the CS protein gene of Plasmodium vivax from field isolates representing geographically distant regions of Papua New Guinea (PNG) and Brazil. In the central repeat region of the CS protein, in addition to variation in the number of repeats, an array of mutations was observed which suggests that point mutations have led to the emergence of the variant CS repeat sequence ANGA(G/D)(N/D)QPG from GDRA(D/A)GQPA. Outside the repeat region of the protein, the nonsilent nucleotide substitutions of independent origin are localized in three domains of the protein that either harbor known T-cell determinants or are analogous to the Plasmodium falciparum immunodominant determinants, Th2R and Th3R. We have found that, with the exception of one CS clone sequence that was shared by one P. vivax isolate each from PNG and Brazil, the P. vivax CS protein types can be grouped into Papuan and Brazilian types. These results suggest that an in-depth study of parasite population dynamics is required before field trials for vaccine formulations based on polymorphic immunodominant determinants are conducted.
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QARI, Shoukat H. et al. Polymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivax. Molecular and Biochemical Parasitology, v. 55, p. 105-114, 1992.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Malária Vivax
Plasmodium vivax
Técnicas de Genotipagem
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Acesso Aberto
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  • SAPAR - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br