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dc.contributor.authorQari, Shoukat H-
dc.contributor.authorGoldman, Ira F-
dc.contributor.authorPóvoa, Marinete Marins-
dc.contributor.authorDi Santi, Sylvia-
dc.contributor.authorAlpers, Michael P-
dc.contributor.authorLal, Altaf A-
dc.date.accessioned2017-06-09T12:55:54Z-
dc.date.available2017-06-09T12:55:54Z-
dc.date.issued1992-
dc.identifier.citationQARI, Shoukat H. et al. Polymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivax. Molecular and Biochemical Parasitology, v. 55, p. 105-114, 1992.pt_BR
dc.identifier.issn0166-6851-
dc.identifier.urihttp://patua.iec.gov.br/handle/iec/2593-
dc.description.abstractThe circumsporozoite (CS) protein that covers the surface of infectious sporozoites is a candidate antigen in malaria vaccine development. To determine the extent of B- and T-epitope polymorphism and to understand the mechanisms of antigenic variability, we have characterized the CS protein gene of Plasmodium vivax from field isolates representing geographically distant regions of Papua New Guinea (PNG) and Brazil. In the central repeat region of the CS protein, in addition to variation in the number of repeats, an array of mutations was observed which suggests that point mutations have led to the emergence of the variant CS repeat sequence ANGA(G/D)(N/D)QPG from GDRA(D/A)GQPA. Outside the repeat region of the protein, the nonsilent nucleotide substitutions of independent origin are localized in three domains of the protein that either harbor known T-cell determinants or are analogous to the Plasmodium falciparum immunodominant determinants, Th2R and Th3R. We have found that, with the exception of one CS clone sequence that was shared by one P. vivax isolate each from PNG and Brazil, the P. vivax CS protein types can be grouped into Papuan and Brazilian types. These results suggest that an in-depth study of parasite population dynamics is required before field trials for vaccine formulations based on polymorphic immunodominant determinants are conducted.pt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePolymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivaxpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryMalária Vivaxpt_BR
dc.subject.decsPrimaryPlasmodium vivaxpt_BR
dc.subject.decsPrimaryTécnicas de Genotipagempt_BR
dc.creator.affilliationCenters for Disease Control, Public Health Services. U.S. Department of Health and Human Services. Division of Parasitic Diseases, National Center for Infectious Diseases. Malaria Branch. Atlanta GA, USA.pt_BR
dc.creator.affilliationCenters for Disease Control, Public Health Services. U.S. Department of Health and Human Services. Division of Parasitic Diseases, National Center for Infectious Diseases. Malaria Branch. Atlanta GA, USA.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationGoverno do Estado de São Paulo. Superintendência de Controle de Endemias. Malaria Department. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationPapua New Guinea Institute of Medical Research. Goroka, PNG.pt_BR


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