• Behavioral and neuropathological changes after Toxoplasma gondii ocular conjunctival infection in BALB/c Mice 

  Soares, Gabrielly Lisboa da Silva; Leão, Ellen Rose Leonardo Ponce de; Freitas, Sinara Franco; Alves, Raissa Maria Carvalho; Tavares, Naiana de Paula; Costa, Maria Vitória Nascimento; Menezes, Gabriel Castro de; Oliveira, Jhonnathan Henrique Palheta de; Guerreiro, Luma Cristina Ferreira; Assis, Alexa Camila Lopes de; Araújo, Sanderson Corrêa; Franco, Felipe Tuji de Castro; Anaissi, Ana Karyssa Mendes; Carmo, Ediclei Lima do; Morais, Rafaela dos Anjos Pinheiro Bogoevich; Demachki, Samia; Diniz, José Antônio Picanço; Nunes, Heloisa Marceliano; Anthony, Daniel C; Diniz, Daniel Guerreiro; Diniz, Cristovam Wanderley Picanço (Frontiers Media, 2022)

  Ocular infection with Toxoplasma gondii causes toxoplasmosis in mice. However, following ocular infection with tachyzoites, the cause of the accompanying progressive changes in hippocampal-dependent tasks, and their ...

• Orthohepadnavirus infection in a neotropical bat (Platyrrhinus lineatus) 

  Souza, Alex Junior Souza de; Malheiros, Andreza Pinheiro; Chagas, André Antônio Corrêa das; Paiva, Vera Lisa Generosa da Silva; Lauri, Liura Sanchez; Scheffer, Karin Corrêa; Mori, Enio; Gouvêa, Michele Soares Gomes; Pinho, João Renato Rebello; Sá, Lilian Rose Marques de (Elsevier, 2021)

  Hepatitis B virus (HBV) is the prototype of the Orthohepadnavirus genus and represents an important cause of chronic hepatitis, liver cirrhosis, and hepatic cancer in humans worldwide. To verify the occurrence and genetic ...

• Microglial metamorphosis in three dimensions in virus limbic encephalitis: an unbiased pictorial representation based on a stereological sampling approach of surveillant and reactive microglia 

  Creão, Leonardo Sávio da Silva; Torres Neto, João Bento; Lima, Camila Mendes de; Reis, Renata Rodrigues dos; Sousa, Aline Andrade de; Santos, Zaire Alves dos; Diniz Junior, José Antônio Picanço; Diniz, Daniel Guerreiro; Diniz, Cristovam Wanderley Picanço (MDPI, 2021)

  Microglia influence pathological progression in neurological diseases, reacting to insults by expressing multiple morphofunctional phenotypes. However, the complete morphological spectrum of reactive microglia, as revealed ...

• Hepatic lesions in captive owl monkeys (Aotus infulatus) with ultrasonographic starry sky liver 

  Souza, Alex Junior Souza de; Coutinho, Leandro Nassar; Silva, Wellington Bandeira da; Imbeloni, Aline Amaral; Carneiro, Liliane Almeida; Kanashiro-Galo, Luciane; Hagen, Stefano Carlo Filippo; Malheiros, Andreza Pinheiro; Sá, Lilian Rose Marques de (Wiley, 2021)

  Background The "starry sky" (SK) liver is ultrasonographic pattern characterized by multiple hyperechogenic foci in hepatic parenchyma. The study aimed to characterize the microscopic hepatic lesions in captive owl monkeys ...

• Plasticity in the hippocampal formation of shorebirds during the wintering period: stereological analysis of parvalbumin neurons in Actitis macularius 

  Guerreiro, Luma Cristina Ferreira; Henrique, Ediely Pereira; Rosa, João Batista da Silva; Pereira, Patrick Douglas Corrêa; Abreu, Cintya Castro de; Fernandes, Taiany Nogueira; Magalhães, Nara Gyzely de Morais; Silva, Anderson de Jesus Falcão da; Costa, Emanuel Ramos da; Diniz, Cristovam Guerreiro; Diniz, Cristovam Wanderley Picanço; Diniz, Daniel Guerreiro (Springer, 2021)

  The number of parvalbumin neurons can be modified by social, multisensory, and cognitive stimuli in both mammals and birds, but nothing is known about their plasticity in long-distance migratory shorebirds. Here, in the ...

• AgNP-PVP-meglumine antimoniate nanocomposite reduces Leishmania amazonensis infection in macrophages 

  Gélvez, Ana Patricia Cacua; Diniz Junior, José Antônio Picanço; Santa Brígida, Thereza Silva; Rodrigues, Ana Paula Drummond (BMC, 2021)

  Background: Leishmaniasis is an infectious disease caused by parasites of the genus Leishmania and presents different clinical manifestations. The adverse effects, immunosuppression and resistant strains associated with ...

• Jejunal injuries in captive marmosets affected by chronic wasting disease 

  Pereira, Washington Luiz Assunção; Diniz Junior, José Antônio Picanço; Muniz, José Augusto Pereira Carneiro; Souza, Alex Junior Souza de; Mendes, Fernanda Figueiredo; Cecim, Amanda Desirée Assunção; Aguirra, Lucien Roberta Valente Miranda de (MS/SVS/Instituto Evandro Chagas, 2021)

  INTRODUCTION: Wasting marmoset syndrome affects the Callitrichidae family reared in captivity, characterized by progressive muscle-weakening and wasting conditions. It has been one of the main causes of death in primates ...

• The fine structure of the axostyle and its associations with organelles in Trichomonads 

  Benchimol, M; Diniz Junior, José Antônio Picanço; Ribeiro, K (Elsevier, 2000)

  The fine structure of the axostyle in the protists Tritrichomonas foetus and Monocercomonas sp is described using transmission electron microscopy after quick-freezing techniques and immunocytochemistry. The axostyle ...

• The fine structure of the Garnia gonadati and its association with the host cell 

  Diniz Junior, José Antonio Picanço; Silva, Edilene Oliveira; Lainson, Ralph; Souza, Wanderley de (Springer Verlag, 2000)

  Most of the studies on the fine structure of protozoa of the Apicomplexa group have been carried out with members of the Toxoplasma, Eimeria, and Plasmodium genera. In the present study we analyzed the fine structure of ...

• Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states 

  Carvalho-Paulo, Dario; Torres Neto, João Bento; Santos Filho, Carlos; Oliveira, Thais Cristina Galdino de; Sousa, Aline Amaral; Reis, Renata Rodrigues dos; Santos, Zaire Alves dos; Lima, Camila Mendes de; Oliveira, Marcus Augusto de; Said, Nivin Mazen; Freitas, Sinara Franco; Sosthenes, Marcia Consentino Kronka; Gomes, Giovanni Freitas; Henrique, Ediely Pereira; Pereira, Patrick Douglas Côrrea; Siqueira, Lucas Silva de; Melo, Mauro André Damasceno de; Diniz, Cristovam Guerreiro; Magalhães, Nara Gyzely de Morais; Diniz Junior, José Antônio Picanço; Vasconcelos, Pedro Fernando da Costa; Diniz, Daniel Guerreiro; Anthony, Daniel Clive; Sherry, David Francis; Brites, Dora; Diniz, Cristovam Wanderley Picanço (Frontiers Media, 2021)

  Microglial immunosurveillance of the brain parenchyma to detect local perturbations in homeostasis, in all species, results in the adoption of a spectrum of morphological changes that reflect functional adaptations. Here, ...

• Acquired acoria and iris pearls in leprosy: case report 

  Morais, Luciana Negrão Almeida; David, Joacy Pedro Franco; Lima, João Victor Peres; Demachki, Samia; Diniz, Daniel Guerreiro; Almeida, Edmundo Frota de (SAGE Publications, 2021)

  Purpose: To describe a case of a patient presenting with acquired acoria and iris pearls, a rare eye manifestation and pathognomonic finding for leprosy; to reinforce clinical, histopathological, and therapeutic aspects ...

• Serological markers for hepatitis a among captive and free-living wild mammals in the State of Para, Brazil 

  Bernal, Marcella Katheryne Marques; Souza, Alex Júnior Souza de; Nunes, Heloisa Marceliano; Malheiros, Andreza Pinheiro; Chagas, André Antônio Corrêa das; Andrade, Sara Letícia dos Santos; Figueiredo, Andréa Lima Silva; Cecim, Amanda Desirée Assunção; Pereira, Washington Luiz Assunção (Universidade do Estado de Londrina, 2021)

  The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have ...

• Sedentary life and reduced mastication impair spatial learning and memory and differentially affect dentate gyrus astrocyte subtypes in the aged mice 

  Mendes, Fabíola de Carvalho Chaves de Siqueira; Paixão, Luisa Taynah Vasconcelos Barbosa; Diniz, Daniel Guerreiro; Anthony, Daniel Clive; Brites, Dora; Diniz, Cristovam Wanderley Picanço; Sosthenes, Marcia Consentino Kronka (Frontiers Media, 2021)

  To explore the impact of reduced mastication and a sedentary lifestyle on spatial learning and memory in the aged mice, as well as on the morphology of astrocytes in the molecular layer of dentate gyrus (MolDG), different ...

• Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection 

  Brito, Caio Vinicius Botelho; Rodrigues, Érika Dayane Leal; Martins, Fernanda Monik Silva; Tavares, Lavínia Dias; Lima, André Luis de Sousa Nogueira; Ferreira, Lucas Carvalho; Santana, Carlos Junior Lopes; Brito, João Augusto Gomes de Souza Monteiro de; Casseb, Lívia Medeiros Neves; Diniz Junior, José Antônio Picanço (Instituto de Medicina Tropical, 2021)

  Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution ...

• Constitutive nitric oxide synthase-like enzyme in two species involved in cutaneous and mucocutaneous leishmaniasis 

  Furtado, Rodrigo R; Soares, Dara C; Prado, Alejandro F; Farias, Luis H. S; Silva, Bruno J. M. da; Rodrigues, Ana P. D; Silva, Edilene O (Elsevier, 2021)

  Leishmania is an obligate intracellular parasite that primarily inhabits macrophages. The destruction of the parasite in the host cell is a fundamental mechanism for infection control. In addition, inhibition of the ...

• Estudo soroepidemiológico do sarampo em populações residentes na Região Metropolitana de Belém, estado do Pará, Brasil, 2016 a 2018 

  Moraes, Marluce Matos de; Sagica, Fernanda do Espirito Santo; Jesus, Maria Izabel; Medeiros, Renato Lopes Fernandes de; Silva, Dorotéa de Fatima Lobato da; Matos, Haroldo José de; Nunes, Heloisa Marceliano; Rodrigues, Sueli Guerreiro (MS/SVS/Instituto Evandro Chagas, 2020)

  OBJETIVO: Investigar a soroprevalência de anticorpos contra o sarampo em adultos jovens, residentes em Belém e Ananindeua, estado do Pará, Brasil, visando identificar indivíduos suscetíveis. MATERIAIS E MÉTODOS: Estudo ...

• Hepatite C na década de 1980: resgate de casos das antigas hepatites "não A e não B" de um serviço de hepatologia na Amazônia, Brasil 

  Barbosa, Kemere Marques Vieira; Moreira, Luiz Vinicius Leão; Oliveira, Candida Maria Abrahão de; Souza, Alex Junior Souza de; Nunes, Heloisa Marceliano; Soares, Manoel do Carmo Pereira; Santos, Lourdes Maria Garcez dos (MS/SVS/Instituto Evandro Chagas, 2019)

  OBJETIVO: Descrever a frequência de infecção pelo vírus da hepatite C (VHC) em amostras de soro de pacientes diagnosticados como hepatite "não-A e não-B", atendidos em um instituto de pesquisa da Amazônia, entre 1982 e ...

• SIPNs polymeric scaffold for use in cartilaginous tissue engineering: physical-chemical evaluation and biological behavior 

  Dias Junior, Elcio Malcher; Dias, Dayane dos Reis Costa; Rodrigues, Ana Paula Drummond; Dias, Carmen Gilda Barroso Tavares; Bastos, Gilmara de Nazareth Tavares; Oliveira, Johnatt Allan Rocha de; Maciel Filho, Rubens; Passos, Marcele Fonseca (Elsevier, 2021)

  Despite the many advances in the field of regenerative medicine, the use of biomaterials to repair the cartilaginous tissue's traumatic injuries is still a challenge. Based on that, this research focuses on the ...

• Occurrence of anti-Toxoplasma gondii and anti-Neospora caninum antibodies in pigs in the State of Pará, Brazil 

  Lopes, Leonardo Machado; Minervino, Antonio Humberto Hamad; Monger, Suellen da Gama Barbosa; Soares, Herbert Sousa; Portela, Juliana Machado; Ferreira, Juliana Isabel Giuli da Silva; Gennari, Solange Maria; Pereira, Washington Luiz Assunção (Colégio Brasileiro de Parasitologia Veterinária, 2021)

  We investigated the occurrence of Toxoplasma gondii and Neospora caninum antibodies in pigs raised in the Northeast of Pará, Brazil. At Study I, convenience sampled 151 pigs at two slaughterhouses, with and without state ...

• Limbic encephalitis brain damage induced by Cocal Virus in adult mice is reduced by environmental enrichment: neuropathological and behavioral studies 

  Freitas, Priscilla dos Santos Lieuthier; Lima, Ana Victória de Lima; Carvalho, Karina Glazianne Barbosa; Cabral, Tatyane da Silva; Farias, Alexandre Maia de; Rodrigues, Ana Paula Drummond; Diniz, Daniel Guerreiro; Dinz, Cristovam Wanderley Picanço; Diniz Junior, José Antônio Picanço (MDPI, 2021)

  We previously demonstrated, using the Piry virus model, that environmental enrichment promotes higher T-cell infiltration, fewer microglial changes, and faster central nervous system (CNS) virus clearance in adult mice. ...

View more