• Activity of alkaloids from Aspidosperma nitidum against Leishmania (Leishmania) amazonensis 

  Veiga, Andreza do Socorro Silva da; Silveira, Fernando Tobias; Silva, Edilene Oliveira da; Diniz Júnior, José Antônio Picanço; Araújo, Sanderson Corrêa; Campos, Marliane Batista; Marinho, Andrey Moacir do Rosário; Brandão, Geraldo Célio; Vale, Valdicley Vieira; Percário, Sandro; Dolabela, Maria Fâni (Nature Research, 2022)

  This study evaluated the morphological changes caused by fractions and subfractions, obtained from barks of Aspidosperna nitidum, against L. (L.) amazonensis promastigotes. The ethanolic extract (EE) obtained through the ...

• Three-dimensional architecture of Cyrilia lignieresi gametocyte-stage development inside red blood cells 

  Silva, Maíra Turiel; Wendt, Camila; Silva, Edilene Oliveira; Rodrigues, Ana Paula Drummond; Souza, Wanderley de; Miranda, Kildare; Diniz, José Antônio Picanço (Wiley, 2022)

  The Haemogregarinidae family (Apicomplexa: Adeleina) comprises hemoprotozoa that infect mammals, birds, amphibians, fish, and reptiles. Some morphological characteristics of the Cyrilia lignieresi have been described ...

• The first evidence of hepatitis A virus subgenotype IIIA in the Eastern Brazilian Amazon, 1982-1983 

  Moreira, Luiz Vinícius Leão; Malheiros, Andreza Pinheiro; Barbosa, Kemere Marques Vieira; Freitas, Pedro Eduardo Bonfim; Silva, Andrea Lima; Cruz, Ana Cecília Ribeiro; Nunes, Heloisa Marceliano; Chagas, Andre Antonio Correa das; Souza, Alex Júnior Souza de (Wiley, 2022)

  Hepatitis A virus (HAV) is a major causative agent of acute hepatitis worldwide. Although discovered in 1973, due to limitations of applicable serological and/or molecular methods, HAV remained under limited diagnosis until ...

• Shorebirds' longer migratory distances are associated with larger ADCYAP1 microsatellites and greater morphological complexity of hippocampal astrocytes 

  Miranda, Diego de Almeida; Araripe, Juliana; Magalhães, Nara G. de Morais; Siqueira, Lucas Silva de; Abreu, Cintya Castro de; Pereira, Patrick Douglas Corrêa; Henrique, Ediely Pereira; Chira, Pedro Arthur Campos da Silva; Melo, Mauro A. D. de; Rêgo, Péricles Sena do; Diniz, Daniel Guerreiro; Sherry, David Francy; Diniz, Cristovam Wanderley Picanço; Diniz, Cristovam Guerreiro (Frontiers Media, 2022)

  For the epic journey of autumn migration, long-distance migratory birds use innate and learned information and follow strict schedules imposed by genetic and epigenetic mechanisms, the details of which remain largely ...

• Oral adenocarcinoma observed in Boa constrictor maintained in captivity 

  Pereira, Washington Luiz Assunção; Bernal, Marcella Katheryne Marques; Costa, Antônio Messias; Imbeloni, Aline Amaral (Universidade Estadual de Londrina, 2022)

  Information on neoplasms in animals has increased over time, and these studies have helped in the management of reptiles that present tumors. There are similar incidences of neoplasms between homeothermic and ectothermic ...

• Behavioral and neuropathological changes after Toxoplasma gondii ocular conjunctival infection in BALB/c Mice 

  Soares, Gabrielly Lisboa da Silva; Leão, Ellen Rose Leonardo Ponce de; Freitas, Sinara Franco; Alves, Raissa Maria Carvalho; Tavares, Naiana de Paula; Costa, Maria Vitória Nascimento; Menezes, Gabriel Castro de; Oliveira, Jhonnathan Henrique Palheta de; Guerreiro, Luma Cristina Ferreira; Assis, Alexa Camila Lopes de; Araújo, Sanderson Corrêa; Franco, Felipe Tuji de Castro; Anaissi, Ana Karyssa Mendes; Carmo, Ediclei Lima do; Morais, Rafaela dos Anjos Pinheiro Bogoevich; Demachki, Samia; Diniz, José Antônio Picanço; Nunes, Heloisa Marceliano; Anthony, Daniel C; Diniz, Daniel Guerreiro; Diniz, Cristovam Wanderley Picanço (Frontiers Media, 2022)

  Ocular infection with Toxoplasma gondii causes toxoplasmosis in mice. However, following ocular infection with tachyzoites, the cause of the accompanying progressive changes in hippocampal-dependent tasks, and their ...

• Orthohepadnavirus infection in a neotropical bat (Platyrrhinus lineatus) 

  Souza, Alex Junior Souza de; Malheiros, Andreza Pinheiro; Chagas, André Antônio Corrêa das; Paiva, Vera Lisa Generosa da Silva; Lauri, Liura Sanchez; Scheffer, Karin Corrêa; Mori, Enio; Gouvêa, Michele Soares Gomes; Pinho, João Renato Rebello; Sá, Lilian Rose Marques de (Elsevier, 2021)

  Hepatitis B virus (HBV) is the prototype of the Orthohepadnavirus genus and represents an important cause of chronic hepatitis, liver cirrhosis, and hepatic cancer in humans worldwide. To verify the occurrence and genetic ...

• Microglial metamorphosis in three dimensions in virus limbic encephalitis: an unbiased pictorial representation based on a stereological sampling approach of surveillant and reactive microglia 

  Creão, Leonardo Sávio da Silva; Torres Neto, João Bento; Lima, Camila Mendes de; Reis, Renata Rodrigues dos; Sousa, Aline Andrade de; Santos, Zaire Alves dos; Diniz Junior, José Antônio Picanço; Diniz, Daniel Guerreiro; Diniz, Cristovam Wanderley Picanço (MDPI, 2021)

  Microglia influence pathological progression in neurological diseases, reacting to insults by expressing multiple morphofunctional phenotypes. However, the complete morphological spectrum of reactive microglia, as revealed ...

• Hepatic lesions in captive owl monkeys (Aotus infulatus) with ultrasonographic starry sky liver 

  Souza, Alex Junior Souza de; Coutinho, Leandro Nassar; Silva, Wellington Bandeira da; Imbeloni, Aline Amaral; Carneiro, Liliane Almeida; Kanashiro-Galo, Luciane; Hagen, Stefano Carlo Filippo; Malheiros, Andreza Pinheiro; Sá, Lilian Rose Marques de (Wiley, 2021)

  Background The "starry sky" (SK) liver is ultrasonographic pattern characterized by multiple hyperechogenic foci in hepatic parenchyma. The study aimed to characterize the microscopic hepatic lesions in captive owl monkeys ...

• Plasticity in the hippocampal formation of shorebirds during the wintering period: stereological analysis of parvalbumin neurons in Actitis macularius 

  Guerreiro, Luma Cristina Ferreira; Henrique, Ediely Pereira; Rosa, João Batista da Silva; Pereira, Patrick Douglas Corrêa; Abreu, Cintya Castro de; Fernandes, Taiany Nogueira; Magalhães, Nara Gyzely de Morais; Silva, Anderson de Jesus Falcão da; Costa, Emanuel Ramos da; Diniz, Cristovam Guerreiro; Diniz, Cristovam Wanderley Picanço; Diniz, Daniel Guerreiro (Springer, 2021)

  The number of parvalbumin neurons can be modified by social, multisensory, and cognitive stimuli in both mammals and birds, but nothing is known about their plasticity in long-distance migratory shorebirds. Here, in the ...

• AgNP-PVP-meglumine antimoniate nanocomposite reduces Leishmania amazonensis infection in macrophages 

  Gélvez, Ana Patricia Cacua; Diniz Junior, José Antônio Picanço; Santa Brígida, Thereza Silva; Rodrigues, Ana Paula Drummond (BMC, 2021)

  Background: Leishmaniasis is an infectious disease caused by parasites of the genus Leishmania and presents different clinical manifestations. The adverse effects, immunosuppression and resistant strains associated with ...

• Jejunal injuries in captive marmosets affected by chronic wasting disease 

  Pereira, Washington Luiz Assunção; Diniz Junior, José Antônio Picanço; Muniz, José Augusto Pereira Carneiro; Souza, Alex Junior Souza de; Mendes, Fernanda Figueiredo; Cecim, Amanda Desirée Assunção; Aguirra, Lucien Roberta Valente Miranda de (MS/SVS/Instituto Evandro Chagas, 2021)

  INTRODUCTION: Wasting marmoset syndrome affects the Callitrichidae family reared in captivity, characterized by progressive muscle-weakening and wasting conditions. It has been one of the main causes of death in primates ...

• The fine structure of the axostyle and its associations with organelles in Trichomonads 

  Benchimol, M; Diniz Junior, José Antônio Picanço; Ribeiro, K (Elsevier, 2000)

  The fine structure of the axostyle in the protists Tritrichomonas foetus and Monocercomonas sp is described using transmission electron microscopy after quick-freezing techniques and immunocytochemistry. The axostyle ...

• The fine structure of the Garnia gonadati and its association with the host cell 

  Diniz Junior, José Antonio Picanço; Silva, Edilene Oliveira; Lainson, Ralph; Souza, Wanderley de (Springer Verlag, 2000)

  Most of the studies on the fine structure of protozoa of the Apicomplexa group have been carried out with members of the Toxoplasma, Eimeria, and Plasmodium genera. In the present study we analyzed the fine structure of ...

• Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states 

  Carvalho-Paulo, Dario; Torres Neto, João Bento; Santos Filho, Carlos; Oliveira, Thais Cristina Galdino de; Sousa, Aline Amaral; Reis, Renata Rodrigues dos; Santos, Zaire Alves dos; Lima, Camila Mendes de; Oliveira, Marcus Augusto de; Said, Nivin Mazen; Freitas, Sinara Franco; Sosthenes, Marcia Consentino Kronka; Gomes, Giovanni Freitas; Henrique, Ediely Pereira; Pereira, Patrick Douglas Côrrea; Siqueira, Lucas Silva de; Melo, Mauro André Damasceno de; Diniz, Cristovam Guerreiro; Magalhães, Nara Gyzely de Morais; Diniz Junior, José Antônio Picanço; Vasconcelos, Pedro Fernando da Costa; Diniz, Daniel Guerreiro; Anthony, Daniel Clive; Sherry, David Francis; Brites, Dora; Diniz, Cristovam Wanderley Picanço (Frontiers Media, 2021)

  Microglial immunosurveillance of the brain parenchyma to detect local perturbations in homeostasis, in all species, results in the adoption of a spectrum of morphological changes that reflect functional adaptations. Here, ...

• Acquired acoria and iris pearls in leprosy: case report 

  Morais, Luciana Negrão Almeida; David, Joacy Pedro Franco; Lima, João Victor Peres; Demachki, Samia; Diniz, Daniel Guerreiro; Almeida, Edmundo Frota de (SAGE Publications, 2021)

  Purpose: To describe a case of a patient presenting with acquired acoria and iris pearls, a rare eye manifestation and pathognomonic finding for leprosy; to reinforce clinical, histopathological, and therapeutic aspects ...

• Serological markers for hepatitis a among captive and free-living wild mammals in the State of Para, Brazil 

  Bernal, Marcella Katheryne Marques; Souza, Alex Júnior Souza de; Nunes, Heloisa Marceliano; Malheiros, Andreza Pinheiro; Chagas, André Antônio Corrêa das; Andrade, Sara Letícia dos Santos; Figueiredo, Andréa Lima Silva; Cecim, Amanda Desirée Assunção; Pereira, Washington Luiz Assunção (Universidade do Estado de Londrina, 2021)

  The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have ...

• Sedentary life and reduced mastication impair spatial learning and memory and differentially affect dentate gyrus astrocyte subtypes in the aged mice 

  Mendes, Fabíola de Carvalho Chaves de Siqueira; Paixão, Luisa Taynah Vasconcelos Barbosa; Diniz, Daniel Guerreiro; Anthony, Daniel Clive; Brites, Dora; Diniz, Cristovam Wanderley Picanço; Sosthenes, Marcia Consentino Kronka (Frontiers Media, 2021)

  To explore the impact of reduced mastication and a sedentary lifestyle on spatial learning and memory in the aged mice, as well as on the morphology of astrocytes in the molecular layer of dentate gyrus (MolDG), different ...

• Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection 

  Brito, Caio Vinicius Botelho; Rodrigues, Érika Dayane Leal; Martins, Fernanda Monik Silva; Tavares, Lavínia Dias; Lima, André Luis de Sousa Nogueira; Ferreira, Lucas Carvalho; Santana, Carlos Junior Lopes; Brito, João Augusto Gomes de Souza Monteiro de; Casseb, Lívia Medeiros Neves; Diniz Junior, José Antônio Picanço (Instituto de Medicina Tropical, 2021)

  Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution ...

• Constitutive nitric oxide synthase-like enzyme in two species involved in cutaneous and mucocutaneous leishmaniasis 

  Furtado, Rodrigo R; Soares, Dara C; Prado, Alejandro F; Farias, Luis H. S; Silva, Bruno J. M. da; Rodrigues, Ana P. D; Silva, Edilene O (Elsevier, 2021)

  Leishmania is an obligate intracellular parasite that primarily inhabits macrophages. The destruction of the parasite in the host cell is a fundamental mechanism for infection control. In addition, inhibition of the ...

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