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Generation, characterization and immunogenicity of a novel chimeric recombinant protein based on Plasmodium vivax AMA-1 and MSP1(19)
(Elsevier, 2017)Plasmodium vivax is the most widely distributed malaria species and the most prevalent species of malaria in America and Asia. Vaccine development against P. vivax is considered a priority in the global program for the ... -
Genetic epidemiology of visceral leishmaniasis in northeastern Brazil
(Wiley, 2001)Familial clustering of disease, racial differences in asymptomatic:disease ratios, and studies of mice all point to a genetic component for disease susceptibility in visceral leishmaniasis. Analysis of 87 multi-case pedigrees ... -
Genetic exchanges as a possible source of genomic diversity in sylvatic populations of Trypanosoma Cruzi
(American Society of Tropical Medicine and Hygiene, 1996)Thirty six stocks of Trypanosoma cruzi isolated from sylvatic mammals (32 Didelphis marsupialis and one Philander opossum) and triatomine bugs (Rhodnius robustus and one unidentified bug) in the Amazonian forest of ... -
Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
(Instituto Oswaldo Cruz, 2005)In this work we investigated the frequency of polymorphism in exon II of the gene encoding most of the amino-terminal region of the serine rich antigen (SERA) in Plasmodium falciparum field samples. The blood samples were ... -
Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)
(BMC, 2018)BACKGROUND: The genetic diversity of malaria antigens often results in allele variant-specific immunity, imposing a great challenge to vaccine development. Rhoptry Neck Protein 2 (PvRON2) is a blood-stage antigen that plays ... -
Genome-wide association study of cell-mediated response in dogs naturally infected by Leishmania infantum
A genome-wide association study (GWAS) could unravel the complexity of the cell-mediated immunity (CMI) to canine leishmaniasis (CanL). Therefore, we scanned 110,165 single-nucleotide polymorphisms (SNPs), aiming to identify ... -
Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians
(Springer Nature, 2004)Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1, 405 markers (10cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric ... -
Geographical distribution of neotropical Leishmania of the subgenus Leishmania analysed by ribosomal oligonucleotide probes
(Oxford University Press, 2000) -
Geometric morphometry of the head in sand flies (Diptera: Psychodidae: Phlebotominae), an alternative approach to taxonomy studies
(Magnolia Press, 2018)Almost 30% of female American sand flies are morphologically indistinguishable from one another. These females belong to species-complexes or groups with closely related species, making species-level identification difficult ... -
Global occorrence of Plasmodium vivax-like human malaria parasite
(Oxford University Press, 1993)A Plasmodium vivax-like human malaria parasite was recently identified from Madang, a holoendemic malarious region in Papua New Guinea. The complete nucleotide sequence of the circumsporozoite (CS) protein gene of this ... -
Granule formation in the accessory glands of a laboratory strain of Lu. longipalpis (Dptera: Phlebotomidae) from Ceará State, Brazil
(Oxford University Press, 1974) -
Granulocyte macrophage colony-stimulating factor alone reduces Toxoplasma gondii replication in microglial culture by superoxide and nitric oxide, without IFN-γ production: a preliminary report
(Elsevier, 2018)In vitro studies have demonstrated that GM-CSF in combination with other stimulatory factors induces a microbicidal response that control T. gondii infection. We assessed whether GM-CSF alone can control T. gondii replication ... -
Hanseníase em metrópole da Amazônia brasileira: cobertura de atenção básica à saúde e sua relação com o perfil clínico e a distribuição espaço-temporal da doença em Belém, estado do Pará, Brasil, de 2006 a 2015
(MS/SVS/Instituto Evandro Chagas, 2019)OBJETIVO: Analisar a distribuição espaço-temporal da hanseníase e a cobertura dos serviços de atenção básica no município de Belém, estado do Pará, Brasil, de 2006 a 2015. MATERIAIS E MÉTODOS: Estudo ecológico, com análise ... -
Hepatite C na década de 1980: resgate de casos das antigas hepatites "não A e não B" de um serviço de hepatologia na Amazônia, Brasil
(MS/SVS/Instituto Evandro Chagas, 2019)OBJETIVO: Descrever a frequência de infecção pelo vírus da hepatite C (VHC) em amostras de soro de pacientes diagnosticados como hepatite "não-A e não-B", atendidos em um instituto de pesquisa da Amazônia, entre 1982 e ... -
High prevalence of G12P[8] rotavirus strains in Rio Branco, Acre, Western Amazon, in the post-rotavirus vaccine introduction period
(Wiley, 2016)The present study aimed to provide a molecular characterization of circulating rotavirus (RVA) strains in Rio Branco, Acre, in the post-rotavirus vaccination period, particularly with regard to the emerging, increasingly ... -
Higher-dose Primaquine to prevent relapse of Plasmodium vivax Malaria
(Massachusetts Medical Society, 2022)BACKGROUND: In most of the Americas, the recommended treatment to prevent relapse of Plasmodium vivax malaria is primaquine at a total dose of 3.5 mg per kilogram of body weight, despite evidence of only moderate ... -
Histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in Plasmodium falciparum isolates from select sites in Brazil and Bolivia
(Public Library of Science, 2017)More than 80% of available malaria rapid diagnostic tests (RDTs) are based on the detection of histidine-rich protein-2 (PfHRP2) for diagnosis of Plasmodium falciparum malaria. Recent studies have shown the genes that code ... -
HIV/AIDS : relação dos níveis de linfócitos tcd4+ e carga viral com o tempo de diagnóstico
(Faculdade de Medicina de São José do Rio Preto, 2016)Introdução: A Síndrome da Imunodeficiência Adquirida é a manifestação causada pelo Vírus da Imunodeficiência Humana, caracterizada por um processo crônico progressivo. O tempo de sobrevida é relacionado à qualidade do ...