SAPAT - Artigos Científicos
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Os documentos disponíveis no repositório são de propriedade e responsabilidade de seus autores, conforme a legislação que rege o direito autoral no país (Lei nº 9.610 , de 19.02.98).
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Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys
(Nature Research, 2021)The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ... -
Prenatal disorders and congenital Zika syndrome in squirrel monkeys
(Nature Research, 2021)During the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this ... -
The innate immune response in Zika virus infection
(Wiley, 2020)Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes ... -
The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
(Wiley, 2020)Covid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and ... -
Meanings and senses of being a health professional with tuberculosis: an interpretative phenomenological study
(BMJ Publishing Group, 2020)OBJECTIVE: The aim of the study was to analyse and understand meanings and senses of living with tuberculosis for health professionals. METHOD/DESIGN: This is an interpretative phenomenological study conducted from in-depth ... -
HTLV-I induces lesions in the pulmonary system: a systematic review
(Elsevier, 2020)This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between ... -
A protocol of hepatic volume measurement using magnetic resonance imaging in individuals from the Eastern Brazilian Amazon population
(Public Library of Science, 2020)Determination of hepatic volume is an important preoperative procedure and is done through imaging exams or standard liver volume (SLV) formulas developed based on the biotype of each population. In the absence of a ... -
Instituto Evandro Chagas: ciência e tecnologia a serviço da vigilância em saúde pública
(MS/ Secretaria de Vigilância Em Saúde, 2019) -
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
(Dove Medical Press, 2019)Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ... -
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
(American Society for Microbiology, 2019)The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together ... -
Doppler ultrasonography: a non-invasive method used to diagnose and follow up patients with chronic hepatitis C
(Wiley, 2020)Background and Aim: This study aimed to investigate the association between the findings of Doppler ultrasonography and transient elastography using FibroScan and to determine the cut-off points, sensitivity, and specificity ... -
Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)
(Elsevier, 2019)The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ... -
Surto de Febre Amarela em bugios
(Arquivos da Faculdade de Veterinária UFRGS, 2003)A febre amarela é uma infecção aguda causada por um Flavivirus (VFA) transmitido por mosquitos, endemica nas regiões tropicais da América do Sul. O objetivo desta nota prévia é relatar a ocorrência de um surto da doença ... -
Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
(Springer Verlag, 2019)Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression ... -
Endoplasmic reticulum stress markers and their possible implications in leprosy's pathogenesis
(Hindawi Publishing Corporation, 2018)Mycobacterium leprae causes leprosy, a dermatoneurological disease which affects the skin and peripheral nerves. One of several cellular structures affected during M. leprae infection is the endoplasmic reticulum (ER). ... -
Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions
(BMC, 2018)Background: Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages ... -
First isolation of West Nile virus in Brazil
(Instituto Oswaldo Cruz, 2019)BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought ... -
Malária por Plasmodium vivax em crianças e adolescentes - aspectos epidemiológicos, clínicos e laboratoriais
(Sociedade Brasileira de Pediatria, 1999)Objetivo: Avaliação dos aspectos epidemiológicos, clínicos e laboratoriais da malária por Plasmodium vivax em crianças e adolescentes. Métodos: No ambulatório do Programa de Malária do Instituto Evandro Chagas (Belém-Pará), ... -
Perfil hematológico de pacientes usuários de amodiaquina
(Editora Den Dabenj, 1997)A malária vivax corresponde a 65% do total da malária notificada no Brasil. A amodiaquina é um esquizonticida sanguíneo eficaz no tratamento da terçã benigna, de elevada tolerância e baixo custo. Há relatos na literatura ... -
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases
(Elsevier, 2018)Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...