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Endoplasmic reticulum stress markers and their possible implications in leprosy's pathogenesis
(Hindawi Publishing Corporation, 2018)Mycobacterium leprae causes leprosy, a dermatoneurological disease which affects the skin and peripheral nerves. One of several cellular structures affected during M. leprae infection is the endoplasmic reticulum (ER). ... -
Estado atual do conhecimento sobre os focos brasileiros de oncocercose
(Sociedade Brasileira de Dermatologia, 1979) -
Estudo experimental sobre a patogenicidade do Vírus Ilhéus em hamsters dourados (Mesocricetus auratus)
(Instituto Evandro Chagas, 2010)Visando investigar a patogenicidade do Flavivirus Ilhéus (VILH) foi inoculada, via intraperitoneal, 9,8 DL de suspensão 50 viral em hamsters dourados jovens (Mesocricetus auratus) e, diariamente, soros e vísceras (cérebro, ... -
Estudo piloto: análise do fígado de ratos submetidos ao alcoolismo crônico experimental e tratados com Morinda citrifolia (noni)
(Instituto Evandro Chagas, 2015)O etilismo crônico causa dano hepático sequencial, desde esteato-hepatite até cirrose e então doença hepática em estágio final. A reparação hepática torna-se comprometida por aumento do estresse oxidativo, danos no DNA, ... -
Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus)
(Elsevier, 2019)The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ... -
Experimental infection of Jorge Lôbo's disease in the cheek-pouch of the golden hamster (Mesocricetus Auratus)
(Universidade de São Paulo, 1970)O agente etiológico da Doença de Jorge Lôbo inoculado na bôlsa jugal de 22 hamsters (Mesocricetus auratus) produziu nódulos de 1,5 a 5 mm de diâmetro constituídos de histiócitos e células gigantes contendo parasitas. As ... -
Factors involved in the apoptotic cell death mechanism in yellow fever hepatitis
(MDPI, 2022)Yellow fever (YF), a non-contagious infectious disease, is endemic or enzootic to the tropical regions of the Americas and Africa. Periodic outbreaks or epidemics have a significant impact on public health. Programmed cell ... -
First isolation of West Nile virus in Brazil
(Instituto Oswaldo Cruz, 2019)BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought ... -
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
(Dove Medical Press, 2019)Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ... -
Hepato-pathological hallmarks for the surveillance of Yellow Fever in South American non-human primates
(Elsevier, 2022)The early detection and diagnosis of deaths in free-ranging non-human primates (NHPs) are key points for the surveillance of Yellow Fever (YF) in Brazil. The histopathological identification of infectious diseases remains ... -
Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys
(Nature Research, 2021)The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ... -
HTLV-I induces lesions in the pulmonary system: a systematic review
(Elsevier, 2020)This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between ... -
Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions
(BMC, 2018)Background: Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages ... -
Importância dos citolisomas na gênese lesional das infecções a virus. Contribuição do estudo ultra-estrutural da infecção experimental de camundongos albinos com o virus Àgua Preta (BeAn 67949)
(Universidade Federal do Pará, 1980)Durante a evolução lesional da infecção experimental por virus A'gua Preta (BeAn67949) foram encontradas estruturas do tipo dos citolisomas ou corpos densos que exibem partículas viróticas de variada estrutura. Esta variação ... -
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
(Nature Publishing Group, 2018)Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been ... -
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases
(Elsevier, 2018)Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ... -
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
(Frontiers Media, 2021)The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for ... -
Instituto Evandro Chagas: ciência e tecnologia a serviço da vigilância em saúde pública
(MS/ Secretaria de Vigilância Em Saúde, 2019) -
Malária por Plasmodium vivax em crianças e adolescentes - aspectos epidemiológicos, clínicos e laboratoriais
(Sociedade Brasileira de Pediatria, 1999)Objetivo: Avaliação dos aspectos epidemiológicos, clínicos e laboratoriais da malária por Plasmodium vivax em crianças e adolescentes. Métodos: No ambulatório do Programa de Malária do Instituto Evandro Chagas (Belém-Pará), ... -
Mansonella ozzardi entre indios ticunas
(Fundação Serviço de Saúde Pública, 1976)