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    • Factors involved in the apoptotic cell death mechanism in yellow fever hepatitis 

      Lopes, Jeferson da Costa; Falcão, Luiz Fábio Magno; Martins Filho, Arnaldo Jorge; Carvalho, Marcos Luiz Gaia; Mendes, Caio Cesar Henriques; Olímpio, Fábio Alves; Miranda, Vanessa do Socorro Cabral; Santos, Lais Carneiro dos; Chiang, Jannifer Oliveira; Cruz, Ana Cecília Ribeiro; Galúcio, Vanessa Costa Alves; Azevedo, Raimunda do Socorro da Silva; Martins, Lívia Caricio; Duarte, Maria Irma Seixas; Sousa, Jorge Rodrigues de; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (MDPI, 2022)
      Yellow fever (YF), a non-contagious infectious disease, is endemic or enzootic to the tropical regions of the Americas and Africa. Periodic outbreaks or epidemics have a significant impact on public health. Programmed cell ...

    • First isolation of West Nile virus in Brazil 

      Martins, Lívia Caricio; Silva, Eliana Vieira Pinto da; Casseb, Lívia Medeiros Neves; Silva, Sandro Patroca da; Cruz, Ana Cecília Ribeiro; Pantoja, Jamilla Augusto de Sousa; Medeiros, Daniele Barbosa de Almeida; Martins Filho, Arnaldo Jorge; Cruz, Ermelinda do Rosário Moutinho da; Araújo, Marialva Tereza Ferreira de; Cardoso, Jedson Ferreira; Cunha, Marcos Antônio Correia da; Almada, Gilton Luiz; Romano, Alessandro Pecego Martins; Santos, Maria Guadalupe Dias Pestana; Rodrigues, Gilsa Aparecida Pimenta; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Carvalho, Valéria Lima; Vasconcelos, Pedro Fernando da Costa (Instituto Oswaldo Cruz, 2019)
      BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought ...

    • Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases 

      Sousa, Jorge Rodrigues de; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (Dove Medical Press, 2019)
      Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ...

    • Hepato-pathological hallmarks for the surveillance of Yellow Fever in South American non-human primates 

      Passos, Pedro Henrique de Oliveira; Ramos, Daniel G; Romano, Alessandro P; Cavalcante, Karina R. L. J; Miranda, Luisa H. M; Coelho, Janice M. C. O; Barros, Ramona C; Martins Filho, Arnaldo Jorge; Quaresma, Juarez Antônio Simões; Macêdo, Isabel L; Wilson, Tais M; Sousa, Davi E. R; Melo, Cristiano B. de; Castro, Marcio B (Elsevier, 2022)
      The early detection and diagnosis of deaths in free-ranging non-human primates (NHPs) are key points for the surveillance of Yellow Fever (YF) in Brazil. The histopathological identification of infectious diseases remains ...

    • Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys 

      Alcantara, Bianca Nascimento de; Imbeloni, Aline Amaral; Durans, Darlene de Brito Simith; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho da; Carvalho, Carlos Alberto Marques de; Mendonça, Maria Helena Rodrigues de; Sousa, Jorge Rodrigues de; Moraes, Adriana Freitas; Martins Filho, Arnaldo Jorge; Lima, Maria de Lourdes Gomes de; Amador Neto, Orlando Pereira; Chiang, Jannifer Oliveira; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa; Medeiros, Daniele Barbosa de Almeida (Nature Research, 2021)
      The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...

    • HTLV-I induces lesions in the pulmonary system: a systematic review 

      Normando, Valéria Marques Ferreira; Dias, Ápio Ricardo Nazareth; Silva, André Luiz Saldanha Eremita da; Pinto, Denise da Silva; Santos, Marcio Clementino de Souza; Rodrigues, Caroline Lobato; Oliveira, Ediléa Monteiro de; Souza Filho, Luiz Euclides Coelho de; Vieira, Waldônio de Brito; Andriolo, Regis Bruni; Sousa, Rita Catarina Medeiros; Falcão, Luiz Fábio Magno; Quaresma, Juarez Antônio Simões (Elsevier, 2020)
      This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between ...

    • Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions 

      Sousa, Jorge Rodrigues de; Lucena Neto, Francisco Dias; Sotto, Mirian Nacagami; Quaresma, Juarez Antônio Simões (BMC, 2018)
      Background: Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages ...

    • Importância dos citolisomas na gênese lesional das infecções a virus. Contribuição do estudo ultra-estrutural da infecção experimental de camundongos albinos com o virus Àgua Preta (BeAn 67949) 

      Araujo, Ronaldo de; Araújo, Marialva Tereza Ferreira de; Pinheiro Filho, Francisco de Paula; Dias, Leonidas Braga (Universidade Federal do Pará, 1980)
      Durante a evolução lesional da infecção experimental por virus A'gua Preta (BeAn67949) foram encontradas estruturas do tipo dos citolisomas ou corpos densos que exibem partículas viróticas de variada estrutura. Esta variação ...

    • In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus 

      Azevedo, Raimunda do Socorro da Silva; Sousa, Jorge Rodrigues de; Araújo, Marialva Tereza Ferreira de; Martins Filho, Arnaldo Jorge; Alcantara, Bianca Nascimento de; Araujo, Fernanda M. C; Queiroz, Maria Goretti Lins de; Cruz, Ana Cecília Ribeiro; Vasconcelos, Beatriz Helena Baldez; Chiang, Jannifer Oliveira; Martins, Lívia Caricio; Casseb, Lívia Medeiros Neves; Silva, Eliana Vieira Pinto da; Carvalho, Valéria Lima; Vasconcelos, Barbara Cristina Baldez; Rodrigues, Sueli Guerreiro; Oliveira, Consuelo Silva de; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Nature Publishing Group, 2018)
      Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been ...

    • In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho; Vasconcelos, Barbara Cristina Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Lívia Caricio; Vasconcelos, Beatriz Helena Baldez; Casseb, Lívia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...

    • Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion 

      Ferreira, Luan Oliveira; Mattos, Bruna Gerrits; Mello, Vanessa Jóia de; Martins Filho, Arnaldo Jorge; Costa, Edmar Tavares da; Yamada, Elizabeth Sumi; Hamoy, Moisés; Lopes, Dielly Catrina Favacho (Frontiers Media, 2021)
      The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for ...

    • Instituto Evandro Chagas: ciência e tecnologia a serviço da vigilância em saúde pública 

      Primo, Mara Barroso; Jocundo, Susana Mika Yahisa; Souza, Cintya de Oliveira; Cavalcante, Gilmara Abreu da Silva; Nunes, Heloisa Marceliano; Carneiro, Bruno Santana; Morais, Rafaela dos Anjos Pinheiro Bogoevich; Martins Filho, Arnaldo Jorge; Linhares, Alexandre da Costa; Ramos, Francisco Lúzio de Paula; Guimarães, Ricardo José de Paula Souza e; Picanço Junior, José Antonio Diniz; Mascarenhas, Joana D’Arc Pereira; Soares, Daniela Cristina; Vieira, Lorena Drumond Loureiro; Matos, Luanna Ematne de; Lima, Marcelo de Oliveira; Silvestre, Rodrigo Vellasco Duarte; Bastos, Fábio Augusto da Silva; Souza, Kelvin Santos de; Sagica, Fernanda do Espirito Santo; Martins, Livia Carício; Carneiro, Liliane Almeida; Viana, Giselle Maria Rachid (MS/ Secretaria de Vigilância Em Saúde, 2019)

    • Malária por Plasmodium vivax em crianças e adolescentes - aspectos epidemiológicos, clínicos e laboratoriais 

      Ventura, Ana Maria Revorêdo da Silva; Pinto, Ana Yecê das Neves; Silva, Rita do Socorro Uchôa da; Calvosa, Vanja Suely Pachiano; Silva Filho, Manoel Gomes da; Souza, José Maria de (Sociedade Brasileira de Pediatria, 1999)
      Objetivo: Avaliação dos aspectos epidemiológicos, clínicos e laboratoriais da malária por Plasmodium vivax em crianças e adolescentes. Métodos: No ambulatório do Programa de Malária do Instituto Evandro Chagas (Belém-Pará), ...

    • Mansonella ozzardi entre indios ticunas 

      Moraes, Mário Augusto Pinto de; Chaves, Geovane M; Alves, Margarida M. R; Lovelace, James (Fundação Serviço de Saúde Pública, 1976)

    • Mansonella ozzardi entre indios ticunas do Estado do Amazonas, Brasil 

      Moraes, Mário Augusto Pinto de; Almeida, Margarida Maria Roque; Lovelace, James K; Chaves, Geovane M (Pan American Sanitary Bureau., 1978)
      Um inquérito no alto Solimões, levado a cabo devido a uma denúncia da existência de Onchocerca volvulus entre os índios Ticunas, habitantes da região, não só mostrou que a denúncia era sem fundamento como também forneceu ...

    • Meanings and senses of being a health professional with tuberculosis: an interpretative phenomenological study 

      Santos, Marcandra Nogueira Almeida; Sá, Antonia Margareth Moita; Quaresma, Juarez Antônio Simões (BMJ Publishing Group, 2020)
      OBJECTIVE: The aim of the study was to analyse and understand meanings and senses of living with tuberculosis for health professionals. METHOD/DESIGN: This is an interpretative phenomenological study conducted from in-depth ...

    • Miocardite experimental em camundongos albinos por virus piry (BeAn 24232). Estudo anátomo-patológico em microscopia óptica e em microscopia eletrônica com demostração da partícula viral 

      Araujo, Ronaldo de; Dias, Leonidas Braga; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho da; Pinheiro Filho, Francisco de Paula (Instituto de Medicina Tropical de São Paulo, 1978)

    • Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil. 

      Freitas, Ronaldo Barros de; Melo, Fernando L; Oliveira, Darleise de Souza; Romano, Camila M; Freitas, Maria Rute Castro; Macêdo, Olinda; Linhares, Alexandre da Costa; Zanotto, Paolo Marinho de Andrade; Durigon, Edison Luiz (Elsevier, 2008)
      Background: Human erythrovirus B19, endemic in the Amazon region since 1990, is associated with a wide spectrum of clinical presentations.Objectives: To assess the prevalence of erythrovirus B19 infection and the relative ...

    • Organization of the skin immune system and compartmentalized immune responses in infectious diseases 

      Quaresma, Juarez Antônio Simões (American Society for Microbiology, 2019)
      The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together ...

    • Perfil hematológico de pacientes usuários de amodiaquina 

      Silva Filho, Manoel Gomes da; Storch, Marcelo; Silva, Damiana; Souza, José Maria de (Editora Den Dabenj, 1997)
      A malária vivax corresponde a 65% do total da malária notificada no Brasil. A amodiaquina é um esquizonticida sanguíneo eficaz no tratamento da terçã benigna, de elevada tolerância e baixo custo. Há relatos na literatura ...