• Perfil laboratorial na doença ictérica de etiologia viral e não viral e a possível relação com a doença renal 

      Silva, Alessandra de Souza e; Silva Filho, Manoel Gomes da; Soares, Manoel do Carmo Pereira; Vieira, José Ricardo dos Santos (Conselho Federal de Farmácia, 2011)
    • Estudo piloto: análise do fígado de ratos submetidos ao alcoolismo crônico experimental e tratados com Morinda citrifolia (noni) 

      Monma, Cristiane Akina; Silva, Naiara Nascimento; Neotti, Tatiane; Coutinho, Victor Augusto Grécia; Brito, Rosângela Baía; Domingues, Robson José de Souza; Ribeiro, Nelson Antonio Bailão (Instituto Evandro Chagas, 2015)
      O etilismo crônico causa dano hepático sequencial, desde esteato-hepatite até cirrose e então doença hepática em estágio final. A reparação hepática torna-se comprometida por aumento do estresse oxidativo, danos no DNA, ...
    • An analysis of the influence of sex hormones on Balb/c mice infected with Plasmodium berghei 

      Lopes, Letícia Nobre; Santos, Felipe Augusto Folha; Oliveira, Louize Caroline Marques; Araujo, Marialva Tereza Ferreira; Sequeira, Carina Guilhon; Libonati, Rosana Maria Feio; Ventura, Ana Maria Revorêdo da Silva (Elsevier, 2015)
      Sex steroids can determine several responses in the clinical evolution of malaria. Seventy Balb-c mice were randomly distributed into 7 groups (10 mice per group): G1 to G6 corresponding to castrated females, castrated ...
    • Avaliação diagnóstica das infecções por vírus Epstein-Barr, parvovírus B19 e vírus linfotrópico de células T humanas em pacientes portadores de lúpus eritematoso sistêmico em hospital de referência do Estado do Pará, Brasil 

      Costa, Igor Brasil; Silva, Mayara Jane Miranda da; Oliveira, Darleise de Souza; Freitas, Felipe Bonfim; Costa, Iran Barros; Meireles, Larissa Teixeira; Santos, Bruna Ramos dos; Oliveira, Andreza Paloma Góes; Melo, Juliana Marinho; Silva, Francinilza magno; Araújo, Kelly Beatriz Romeiro; Palaro, Alessandra Alves; Moura, Antônio; Macedo, Olinda; Monteiro, Talita Antônia Furtado; Silva Filho, Manoel Gomes da; Viana Júnior, Wellington Teixeira; Kahwage, Carolina Barros (Instituto Evandro Chagas, 2016)
      O lúpus eritematoso sistêmico (LES) é uma doença autoimune crônica, cujo desenvolvimento pode estar associado à infecção por vírus, como o vírus Epstein-Barr (EBV), parvovírus B19 e vírus linfotrópico de células T ...
    • Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions 

      Sousa, Jorge Rodrigues de; Lucena Neto, Francisco Dias; Sotto, Mirian Nacagami; Quaresma, Juarez Antonio Simões (BMC, 2018)
      Background: Since macrophages are one of the major cell types involved in the Mycobacterium leprae immune response, roles of the M1 and M2 macrophage subpopulations have been well defined. However, the role of M4 macrophages ...
    • Clinical and immunological profiles of anaemia in children and adolescents with Plasmodium vivax malaria in the Pará state, Brazilian Amazon 

      Ventura, Ana Maria Revoredo da Silva; Fernandes, Andrea Aparecida Moraes; Zanini, Graziela Maria; Pratt-Riccio, Lilian Rose; Sequeira, Carina Guilhon; Monte, Carlos Rodrigo Souza do; Martins Filho, Arnaldo Jorge; Machado, Ricardo Luiz Dantas; Libonati, Rosana Maria Feio; Souza, José Maria de; Daniel-Ribeiro, Cláudio Tadeu (Elsevier, 2018)
      Children and adolescents are at great risk for developing iron deficiency anaemia worldwide. In the tropical areas, malaria and intestinal parasites may also play an important role in anaemia pathogenesis. This study aimed ...
    • In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus 

      Azevedo, Raimunda do Socorro da Silva; Sousa, Jorge R. de; Araújo, Marialva Tereza Ferreira de; Martins Filho, Arnaldo J; Alcantara, Bianca Nascimento de; Araujo, Fernanda M. C; Queiroz, Maria G. L.; Cruz, Ana Cecília Ribeiro; Vasconcelos, Beatriz H Baldez; Chiang, Jannifer Oliveira; Martins, Lívia Caricio; Casseb, Livia Medeiros Neves; Silva, Eliana Vieira Pinto da; Carvalho, Valéria Lima; Vasconcelos, Barbara C. Baldez; Rodrigues, Sueli Guerreiro; Oliveira, Consuelo Silva de; Quaresma, Juarez A. S; Vasconcelos, Pedro Fernando da Costa (Nature Publishing Group, 2018)
      Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been ...
    • In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho; Vasconcelos, Barbara Cristina Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Livia Carício; Vasconcelos, Beatriz Helena Baldez; Casseb, Livia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antonio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...
    • Endoplasmic reticulum stress markers and their possible implications in leprosy's pathogenesis 

      Hirai, Kelly Emi; Sousa, Jorge Rodrigues de; Silva, Luciana Mota; Dias Junior, Leônidas Braga; Furlaneto, Ismari Perini; Carneiro, Francisca Regina Oliveira; Aarão, Tinara Leila de Souza; Sotto, Mirian Nacagami; Quaresma, Juarez Antonio Simões (Hindawi Publishing Corporation, 2018)
      Mycobacterium leprae causes leprosy, a dermatoneurological disease which affects the skin and peripheral nerves. One of several cellular structures affected during M. leprae infection is the endoplasmic reticulum (ER). ...
    • Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika Virus 

      Sousa, Jorge R. de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva T. F; Moutinho, Ermelinda R. C; Vasconcelos, Barbara C. Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Lívia Carício; Vasconcelos, Beatriz H. Baldez; Casseb, Livia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) is a single-stranded positive-sense RNA flavivirus that possesses a genome approximately 10.7 Kb in length. Although pro-inflammatory and anti-inflammatory cytokines and apoptotic markers belonging to the ...
    • Organization of the skin immune system and compartmentalized immune responses in infectious diseases 

      Quaresma, Juarez Antônio Simões (American Society for Microbiology, 2019)
      The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together ...
    • Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases 

      Sousa, Jorge Rodrigues de; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (Dove Medical Press, 2019)
      Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ...
    • Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus) 

      Matos, Gabriel Costa; Ferreira, Milene Silveira; Martins Filho, Arnaldo Jorge; Amador Neto, Orlando Pereira; Campos, Valter Miranda; Lima, Maria de Lourdes Gomes de; Rodrigues, Jéssica Cecília Pinheiro; Ribeiro, Ana Claudia da Silva; Freitas, Maria de Nazaré Oliveira; Silva, Franko de Arruda e; Chiang, Jannifer Oliveira; Casseb, Livia Medeiros Neves; Sousa, Jorge Rodrigues de; Quaresma, Juarez Antônio Simões; Martins, Lívia Carício; Vasconcelos, Pedro Fernando da Costa; Carvalho, Valéria Lima (Elsevier, 2019)
      The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ...
    • First isolation of West Nile virus in Brazil 

      Martins, Lívia Caricio; Silva, Eliana Vieira Pinto da; Casseb, Livia Medeiros Neves; Silva, Sandro Patroca da; Cruz, Ana Cecília Ribeiro; Pantoja, Jamilla Augusto de Sousa; Medeiros, Daniele Barbosa de Almeida; Martins Filho, Arnaldo Jorge; Cruz, Ermelinda do Rosário Moutinho da; Araújo, Marialva Tereza Ferreira de; Cardoso, Jedson Ferreira; Cunha, Marcos Antônio Correia da; Almada, Gilton Luiz; Romano, Alessandro Pecego Martins; Santos, Maria Guadalupe Dias Pestana; Rodrigues, Gilsa Aparecida Pimenta; Chiang, Jannifer Oliveira; Quaresma, Juarez Antonio Simões; Carvalho, Valéria Lima; Vasconcelos, Pedro Fernando da Costa (Instituto Oswaldo Cruz, 2019)
      BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought ...
    • Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2 

      Holanda, Gustavo Moraes; Casseb, Samir Mansour Moraes; Quaresma, Juarez Antonio Simões; Vasconcelos, Pedro Fernando da Costa; cruz, Ana Cecília Ribeiro (Springer Verlag, 2019)
      Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression ...
    • Instituto Evandro Chagas: ciência e tecnologia a serviço da vigilância em saúde pública 

      Primo, Mara Barroso; Jocundo, Susana M. Y; Souza, Cintya de Oliveira; Cavalcante, Gilmara Abreu da Silva; Nunes, Heloisa Marceliano; Carneiro, Bruno Santana; Morais, Rafaela dos Anjos Pinheiro Bogoevich; Martins Filho, Arnaldo Jorge; Linhares, Alexandre da Costa; Ramos, Francisco Lúzio de Paula; Guimarães, Ricardo José de Paula Souza e; Picanço Junior, José Antonio Diniz; Mascarenhas, Joana D’Arc Pereira; Soares, Daniela Cristina; Vieira, Lorena Drumond Loureiro; Matos, Luanna Ematne de; Lima, Marcelo de Oliveira; Silvestre, Rodrigo Vellasco Duarte; Bastos, Fábio Augusto da Silva; Souza, Kelvin Santos de; Sagica, Fernanda do Espirito Santo; Martins, Livia Carício; Carneiro, Liliane Almeida; Viana, Giselle Maria Rachid (MS/ Secretaria de Vigilância Em Saúde, 2019)
    • Doppler ultrasonography: a non-invasive method used to diagnose and follow up patients with chronic hepatitis C 

      Franco, Karen Margarete Vieira da Silva; Vieira, Waldonio Brito; Dias, Apio Ricardo Nazareth; Falcão, Aline Semblano Carreira; Falcão, Luiz Fábio Magno; Quaresma, Juarez Antônio Simões (Wiley, 2020)
      Background and Aim: This study aimed to investigate the association between the findings of Doppler ultrasonography and transient elastography using FibroScan and to determine the cut-off points, sensitivity, and specificity ...
    • A protocol of hepatic volume measurement using magnetic resonance imaging in individuals from the Eastern Brazilian Amazon population 

      Oliveira, Robson Tadachi Moraes de; Dias, Apio Ricardo Nazareth; Vieira, Waldônio Brito; Falcão, Aline Semblano Carreira; Falcão, Luiz Fábio Magno; Quaresma, Juarez Antônio Simões (Public Library of Science, 2020)
      Determination of hepatic volume is an important preoperative procedure and is done through imaging exams or standard liver volume (SLV) formulas developed based on the biotype of each population. In the absence of a ...
    • HTLV-I induces lesions in the pulmonary system: a systematic review 

      Normando, Valéria Marques Ferreira; Dias, Ápio Ricardo Nazareth; Silva, André Luiz Saldanha Eremita da; Pinto, Denise da Silva; Santos, Marcio Clementino de Souza; Rodrigues, Caroline Lobato; Oliveira, Ediléa Monteiro de; Souza Filho, Luiz Euclides Coelho de; Vieira, Waldônio de Brito; Andriolo, Regis Bruni; Sousa, Rita Catarina Medeiros; Falcão, Luiz Fábio Magno; Quaresma, Juarez Antônio Simões (Elsevier, 2020)
      This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between ...
    • Meanings and senses of being a health professional with tuberculosis: an interpretative phenomenological study 

      Santos, Marcandra Nogueira Almeida; Sá, Antonia Margareth Moita; Quaresma, Juarez Antônio Simões (BMJ Publishing Group, 2020)
      OBJECTIVE: The aim of the study was to analyse and understand meanings and senses of living with tuberculosis for health professionals. METHOD/DESIGN: This is an interpretative phenomenological study conducted from in-depth ...