• Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika Virus 

      Sousa, Jorge R. de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva T. F; Moutinho, Ermelinda R. C; Vasconcelos, Barbara C. Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Lívia Carício; Vasconcelos, Beatriz H. Baldez; Casseb, Livia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) is a single-stranded positive-sense RNA flavivirus that possesses a genome approximately 10.7 Kb in length. Although pro-inflammatory and anti-inflammatory cytokines and apoptotic markers belonging to the ...
    • Estudo experimental sobre a patogenicidade do Vírus Ilhéus em hamsters dourados (Mesocricetus auratus) 

      Azevedo, Raimunda do Socorro da Silva; Barros, Vera Lúcia Reis de Souza; Matins, Lívia Caricio; Cruz, Ana Cecília Ribeiro; Rodrigues, Sueli Guerreiro; Vasconcelos, Pedro Fernando da Costa (Instituto Evandro Chagas, 2010)
      Visando investigar a patogenicidade do Flavivirus Ilhéus (VILH) foi inoculada, via intraperitoneal, 9,8 DL de suspensão 50 viral em hamsters dourados jovens (Mesocricetus auratus) e, diariamente, soros e vísceras (cérebro, ...
    • In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus 

      Azevedo, Raimunda do Socorro da Silva; Sousa, Jorge R. de; Araújo, Marialva Tereza Ferreira de; Martins Filho, Arnaldo J; Alcantara, Bianca Nascimento de; Araujo, Fernanda M. C; Queiroz, Maria G. L.; Cruz, Ana Cecília Ribeiro; Vasconcelos, Beatriz H Baldez; Chiang, Jannifer Oliveira; Martins, Lívia Caricio; Casseb, Livia Medeiros Neves; Silva, Eliana Vieira Pinto da; Carvalho, Valéria Lima; Vasconcelos, Barbara C. Baldez; Rodrigues, Sueli Guerreiro; Oliveira, Consuelo Silva de; Quaresma, Juarez A. S; Vasconcelos, Pedro Fernando da Costa (Nature Publishing Group, 2018)
      Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been ...
    • In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho; Vasconcelos, Barbara Cristina Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Livia Carício; Vasconcelos, Beatriz Helena Baldez; Casseb, Livia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antonio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...
    • The innate immune response in Zika virus infection 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Wiley, 2020)
      Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes ...