• An epidemic of sylvatic yellow fever in the Southeast region of Maranhao State, Brazil, 1993-1994: epidemiologic and entomologic findings 

      Vasconcelos, Pedro Fernando da Costa; Rodrigues, Sueli Guerreiro; Dégallier, Nicolas; Moraes, Mário Augusto Pinto de; Rosa, Jorge Fernando Soares Travassos da; Rosa, Elizabeth Salbé Travassos da; Mondet, Bernard; Barros, Vera Lúcia Reis Souza de; Rosa, Amélia Paes de Andrade Travassos da (American Society of Tropical Medicine and Hygiene, 1997)
      Yellow fever virus transmission was very active in Maranhao State in Brazil in 1993 and 1994. An investigation was carried out to evaluate the magnitude of the epidemic. In 1993, a total of 932 people was examined for ...
    • Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika Virus 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho da; Vasconcelos, Barbara Cristina Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Lívia Caricio; Vasconcelos, Beatriz Helena Baldez; Casseb, Lívia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) is a single-stranded positive-sense RNA flavivirus that possesses a genome approximately 10.7 Kb in length. Although pro-inflammatory and anti-inflammatory cytokines and apoptotic markers belonging to the ...
    • Estudo experimental sobre a patogenicidade do Vírus Ilhéus em hamsters dourados (Mesocricetus auratus) 

      Azevedo, Raimunda do Socorro da Silva; Barros, Vera Lúcia Reis Souza de; Martins, Lívia Caricio; Cruz, Ana Cecília Ribeiro; Rodrigues, Sueli Guerreiro; Vasconcelos, Pedro Fernando da Costa (Instituto Evandro Chagas, 2010)
      Visando investigar a patogenicidade do Flavivirus Ilhéus (VILH) foi inoculada, via intraperitoneal, 9,8 DL de suspensão 50 viral em hamsters dourados jovens (Mesocricetus auratus) e, diariamente, soros e vísceras (cérebro, ...
    • Experimental infection of golden hamsters with Guama virus (Peribunyaviridae, Orthobunyavirus) 

      Matos, Gabriel Costa; Ferreira, Milene Silveira; Martins Filho, Arnaldo Jorge; Amador Neto, Orlando Pereira; Campos, Valter Miranda; Lima, Maria de Lourdes Gomes de; Rodrigues, Jéssica Cecília Pinheiro; Ribeiro, Ana Claudia da Silva; Freitas, Maria de Nazaré Oliveira; Silva, Franko de Arruda e; Chiang, Jannifer Oliveira; Casseb, Lívia Medeiros Neves; Sousa, Jorge Rodrigues de; Quaresma, Juarez Antônio Simões; Martins, Lívia Caricio; Vasconcelos, Pedro Fernando da Costa; Carvalho, Valéria Lima (Elsevier, 2019)
      The Guama virus (GMAV) is a member of Peribunyaviridae family, Orthobunyavirus genus. Several strains of the virus were isolated in South and Central Americas from several hosts, such as humans, wild animals, including nonhuman ...
    • Factors involved in the apoptotic cell death mechanism in yellow fever hepatitis 

      Lopes, Jeferson da Costa; Falcão, Luiz Fábio Magno; Martins Filho, Arnaldo Jorge; Carvalho, Marcos Luiz Gaia; Mendes, Caio Cesar Henriques; Olímpio, Fábio Alves; Miranda, Vanessa do Socorro Cabral; Santos, Lais Carneiro dos; Chiang, Jannifer Oliveira; Cruz, Ana Cecília Ribeiro; Galúcio, Vanessa Costa Alves; Azevedo, Raimunda do Socorro da Silva; Martins, Lívia Caricio; Duarte, Maria Irma Seixas; Sousa, Jorge Rodrigues de; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (MDPI, 2022)
      Yellow fever (YF), a non-contagious infectious disease, is endemic or enzootic to the tropical regions of the Americas and Africa. Periodic outbreaks or epidemics have a significant impact on public health. Programmed cell ...
    • First isolation of West Nile virus in Brazil 

      Martins, Lívia Caricio; Silva, Eliana Vieira Pinto da; Casseb, Lívia Medeiros Neves; Silva, Sandro Patroca da; Cruz, Ana Cecília Ribeiro; Pantoja, Jamilla Augusto de Sousa; Medeiros, Daniele Barbosa de Almeida; Martins Filho, Arnaldo Jorge; Cruz, Ermelinda do Rosário Moutinho da; Araújo, Marialva Tereza Ferreira de; Cardoso, Jedson Ferreira; Cunha, Marcos Antônio Correia da; Almada, Gilton Luiz; Romano, Alessandro Pecego Martins; Santos, Maria Guadalupe Dias Pestana; Rodrigues, Gilsa Aparecida Pimenta; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Carvalho, Valéria Lima; Vasconcelos, Pedro Fernando da Costa (Instituto Oswaldo Cruz, 2019)
      BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought ...
    • Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases 

      Sousa, Jorge Rodrigues de; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (Dove Medical Press, 2019)
      Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of ...
    • Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys 

      Alcantara, Bianca Nascimento de; Imbeloni, Aline Amaral; Durans, Darlene de Brito Simith; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho da; Carvalho, Carlos Alberto Marques de; Mendonça, Maria Helena Rodrigues de; Sousa, Jorge Rodrigues de; Moraes, Adriana Freitas; Martins Filho, Arnaldo Jorge; Lima, Maria de Lourdes Gomes de; Amador Neto, Orlando Pereira; Chiang, Jannifer Oliveira; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa; Medeiros, Daniele Barbosa de Almeida (Nature Research, 2021)
      The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...
    • In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus 

      Azevedo, Raimunda do Socorro da Silva; Sousa, Jorge Rodrigues de; Araújo, Marialva Tereza Ferreira de; Martins Filho, Arnaldo Jorge; Alcantara, Bianca Nascimento de; Araujo, Fernanda M. C; Queiroz, Maria Goretti Lins de; Cruz, Ana Cecília Ribeiro; Vasconcelos, Beatriz Helena Baldez; Chiang, Jannifer Oliveira; Martins, Lívia Caricio; Casseb, Lívia Medeiros Neves; Silva, Eliana Vieira Pinto da; Carvalho, Valéria Lima; Vasconcelos, Barbara Cristina Baldez; Rodrigues, Sueli Guerreiro; Oliveira, Consuelo Silva de; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Nature Publishing Group, 2018)
      Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed ...
    • In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Martins Filho, Arnaldo Jorge; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho; Vasconcelos, Barbara Cristina Baldez; Cruz, Ana Cecília Ribeiro; Oliveira, Consuelo Silva de; Martins, Lívia Caricio; Vasconcelos, Beatriz Helena Baldez; Casseb, Lívia Medeiros Neves; Chiang, Jannifer Oliveira; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2018)
      Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that ...
    • Prenatal disorders and congenital Zika syndrome in squirrel monkeys 

      Imbeloni, Aline Amaral; Alcantara, Bianca Nascimento de; Coutinho, Leandro Nassar; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Oliveira, Karol Guimarães; Martins Filho, Arnaldo Jorge; Durans, Darlene de Brito Simith; Silva, Wellington Bandeira da; Nunes, Bruno Tardelli Diniz; Casseb, Lívia Medeiros Neves; Chiang, Jannifer Oliveira; Carvalho, Carlos Alberto Marques de; Machado, Mariana Borges; Quaresma, Juarez Antônio Simões; Medeiros, Daniele Barbosa de Almeida; Vasconcelos, Pedro Fernando da Costa (Nature Research, 2021)
      During the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this ...
    • Surto de raiva humana transmitida por morcegos no Município de Portel-Pará, março/abril de 2004 

      Wada, Marcelo Yoshito; Begot, Alberto Lopes; Noronha, Sandra Lucia Balbi; Almeida, Ilse Freitas de; Lima, Reynaldo José da Silva; Santos, Liette Benedita C. dos; Monteiro, Ademar; Cruz, Rutidélia Silva da; Silva, Isabel Nazaré Oliveira e; Soares, Dulcinéia da Silva; Pinheiro, Amiraldo da Silva; Moraes, José Raimundo Farias de; Tenório, Adail dos Santos; Pereira, Alexandre Gley Garcia; Penha, Tânia Cristine da; Rosa, Elizabeth Salbé Travassos da; Barros, Vera Lúcia Reis Souza de; Vasconcelos, Pedro Fernando da Costa; Barbosa, Taciana Fernandes Souza; Kotait, Ivanete; Souza, José Carlos Pereira de; Gitti, Clayton Bernardinelli; Uieda, Wilson; Montebello, Lúcia Regina; Carmo, Eduardo Hage; Oliveira, Rosely Cerqueira de; Hatch, Douglas L (Ministério da Saúde. Secretaria de Vigilância em Saúde, 2004)
    • Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection 

      Mendes, Caio Cesar Henriques; Sousa, Jorge Rodrigues de; Olímpio, Fábio Alves; Falcão, Luiz Fábio Magno; Carvalho, Marcos Luiz Gaia; Lopes, Jeferson da Costa; Martins Filho, Arnaldo Jorge; Miranda, Vanessa do Socorro Cabral; Santos, Lais Carneiro dos; Vilacoert, Felipe Souza da Silva; Galúcio, Vanessa Costa Alves; Azevedo, Raimunda do Socorro da Silva; Martins, Lívia Caricio; Duarte, Maria Irma Seixas; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (Elsevier, 2022)
      Yellow fever (YF) is an infectious disease considered a public health problem in tropical and subtropical areas. YF has many pathophysiological events that are correlated with the host immune response. In this study, the ...
    • The innate immune response in Zika virus infection 

      Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Wiley, 2020)
      Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes ...
    • Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2 

      Holanda, Gustavo Moraes; Casseb, Samir Mansour Moraes; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa; Cruz, Ana Cecília Ribeiro (Springer Verlag, 2019)
      Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression ...