• Astrovírus infection in hospitalized children: molecular, clinical and epidemiological features 

      Siqueira, Jones Anderson Monteiro; Oliveira, Darleise de Souza; Carvalho, Thaís Cristina Nascimento de; Portal, Thayara Morais; Justino, Maria Cleonice Aguiar; Silva, Luciana Damascena da; Resque, Hugo Reis; Gabbay, Yvone Benchimol (Elsevier, 2017)
      Background: Astrovirus (HAstV) is a common viral pathogen that causes gastroenteritis worldwide. It is classified into eight classical human types (HAstV-1/8) and seven other less prevalent types, described as HAstV VA1, ...
    • Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6 

      Justino, Maria Cleonice Aguiar; Mesquita, Deisiane da S; Souza, Maurício F; Farias, Francisco P; Alves, Jainara Cristina dos S; Ferreira, James L; Lopes, Daniela P; Tavares, Fernando Neto (Elsevier, 2020)
      BACKGROUND: Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past 5 years, however, CV-A6 has emerged as ...
    • Characterization of novel intragenotype recombination events among norovirus pandemic GII.4 variants 

      Siqueira, Jones Anderson Monteiro; Bandeira, Renato da Silva; Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa; Gabbay, Yvone Benchimol (Elsevier, 2016)
      Recently, there has been an increase in the number of children hospitalized due to norovirus infection in Brazil. This is due both to the occurrence of more severe norovirus-related gastroenteritis cases after the introduction ...
    • Clinical severity and rotavirus vaccination among children hospitalized for ccute gastroenteritis in Belém, Northern Brazil 

      Justino, Maria Cleonice Aguiar; Brasil, Patrícia; Abreu, Erika; Miranda, Yllen; Mascarenhas, Joana D'Arc Pereira; Guerra, Sylvia de Fátima dos Santos; Linhares, Alexandre da Costa (Oxford University Press, 2016)
      In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (RotarixTM) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among ...
    • Detecção de antígenos de rotavírus no soro de crianças hospitalizadas por gastroenterite aguda em Belém, Estado do Pará, Brasil 

      Justino, Maria Cleonice Aguiar; Campos, Erika Maria Nogueira de Abreu; Mascarenhas, Joana D'Arc Pereira; Soares, Luana da Silva; Soares, Sissa Gabrielle Ribeiro; Soares, Tassia Salgado; Povão Júnior, Manoel Jaime Castro; Bezerra, Orvácio Melo; Maciel, Tássio Sampaio; Farias, Fredison Pinheiro; Linhares, Alexandre da Costa (Instituto Evandro Chagas, 2016)
      Os rotavírus (RV) são os principais agentes virais causadores de gastroenterite (GE) aguda na infância, sendo responsáveis por milhares de óbitos em crianças com diarreia, em âmbito global, especialmente nos países ...
    • Detection and genetic characterization of the emergent GII.17_2014 norovirus genotype among children with gastroenteritis from Northern Brazil. 

      Silva, Luciana Damascena da; Bandeira, Renato da Silva; Sousa Júnior, Edivaldo Costa; Lima, Ian Carlos Gomes de; Penha Júnior, Edvaldo Tavares da; Teixeira, Dielle Monteiro; Siqueira, Jones Anderson Monteiro; Resque, Hugo Reis; Campos, Erika Maria Nogueira de Abreu; Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa; Gabbay, Yvone Benchimol (Elsevier, 2017)
      Norovirus is the most important cause of viral gastroenteritis outbreaks worldwide. Recently, a novel GII.17 norovirus variant emerged and caused epidemics in Asian countries, replacing the GII.4 Sydney 2012 strain in ...
    • Detection and genotyping of enteric viruses in hospitalized children with acute gastroenteritis in Belém, Brazil: occurrence of adenovirus viremia by species F, types 40/41 

      Portal, Thayara Morais; Reymão, Tammy Kathlyn Amaral; Quinderé Neto, Germano Alves; Fiuza, Mercedes Kamila da C; Teixeira, Dielle Monteiro; Lima, Ian Carlos Gomes; Sousa Júnior, Edivaldo Costa; Bandeira, Renato da Silva; Deus, Danielle Rodrigues de; Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa; Silva, Luciana Damascena da; Resque, Hugo Reis; Gabbay, Yvone Benchimol (Wiley, 2019)
      Enteric adenovirus (AdV), sapovirus (SaV), and human astrovirus (HAstV) are important pathogens involved in the gastroenteritis etiology. In this study, a total of 219 fecal samples and sera were collected from children ...
    • Effectiveness of the monovalent G1P[8] human rotavirus vaccine against hospitalization for severe G2P[4] rotavirus gastroenteritis in Belém, Brazil 

      Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa; Lanzieri, Tatiana. M; Miranda, Ylle; Mascarenhas, Joana D'Arc Pereira; Abreu, Erika; Guerra, Sylvia de Fátima dos Santos; Oliveira, Alessilva S. L; Silva, Veronice B da; Sanchez, Nervo; Meyer, Nadia; Shafi, Fakrudeen; Ortega-Barria, Eduardo; Soriano-Gabarró, Montse; Colindres, Romulo E (Lippincott, Williams & Wilkins, 2011)
      Background: Brazil initiated universal immunization of infants with the G1P[8] human rotavirus (RV) vaccine in March 2006. This study evaluated vaccine effectiveness (VE) against severe rotavirus gastroenteritis (RVGE) ...
    • Effectiveness of the monovalent G1P[8] rotavirus vaccine against hospitalization for severe G2P[4] rotavirus gastroenteritis in Belém, Brazil. 

      Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa; Lanzieri, Tatiana M; Miranda, Yllen; Mascarenhas, Joana D'Arc Pereira; Abreu, Erika; Guerra, Sylvia de Fátima dos Santos; Oliveira, Alessilva do Socorro Lima de; Silva, Veronilce B da; Sanchez, Nervo; Meyer, Nadia; Shafi, Fakrudeen; Ortega-Barria, Eduardo; Soriano-Gabarró, Montse; Colindres, Romulo E (Lippincott, Williams & Wilkins, 2011)
      Background: Brazil initiated universal immunization of infants with the G1P_8_ human rotavirus (RV) vaccine in March 2006. This study evaluated vaccine effectiveness (VE) against severe rotavirus gastroenteritis (RVGE) ...
    • Emergence of G12P[6] rotavirus strains among hospitalised children with acute gastroenteritis in Belém, Northern Brazil, following introduction of a rotavirus vaccine 

      Guerra, Sylvia de Fátima dos Santos; Fecury, Priscylla C. M. S; Bezerra, Delana Andreza Melo; Lobo, Patricia S.; Penha Júnior, Edvaldo Tavares da; Sousa Júnior, Edivaldo Costa; Mascarenhas, Joana D'Arc Pereira; Soares, Luana da Silva; Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa (Springer Verlag, 2019)
      Species A rotavirus still remains a major cause of acute gastroenteritis in infants and young children. Globally, six genotypes (G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]) account for >90% of circulating strains; ...
    • Group A rotavirus and norovirus display sharply distinct seasonal profiles in Belém, northern Brazil 

      Siqueira, Jones Anderson Monteiro; Linhares, Alexandre da Costa; Gonçalves, Maryelle dos Santos; Carvalho, Thaís Cristina Nascimento de; Justino, Maria Cleonice Aguiar; Mascarenhas, Joana D'Arc Pereira; Gabbay, Yvone Benchimol (Instituto Oswaldo Cruz, 2013)
      Several viruses have been associated with acute gastroenteritis (AGE), and group A rotavirus (RVA) and nor-ovirus (NoV) are the most prevalent. This study aimed to assess their prevalence among children hospitalised for ...
    • Multisystem inflammatory syndrome associated with coronavirus disease in children a multi-centered study in Belem, Para, Brazil 

      Farias, Emmerson Carlos Franco de; Piva, Jefferson Pedro; Mello, Mary Lucy Ferraz Maria Fiuza de; Nascimento, Luciana M. P. P. do; Costa, Carina C; Machado, Mayara M. M; Rodrigues, Thatiane da S; Carvalho, Railana D. F. P; Alves, Marília C. B; Aires, Larisse F. Q; Cotta, Marilia L. M; Pedreira, Ana R. G; Saraty, Salma B; Lima, Miriam C; Justino, Maria Cleonice Aguiar (Lippincott, Williams & Wilkins, 2020)
      We described the characteristics of 11 children with pediatric multisystem inflammatory syndrome-temporally associated with SARS-CoV-2. The main clinical indications for hospital admission were vasogenic toxic shock (n = ...
    • Norovirus infection in children admitted to hospital for acute gastroenteritis in Belém, Pará, Northern Brazil 

      Siqueira, Jones Anderson Monteiro; Linhares, Alexandre da Costa; Carvalho, Thaís Cristina Nascimento de; Aragão, Glicélia Cruz; Oliveira, Darleise de Souza; Santos, Mirleide Cordeiro dos; Sousa, Maisa Silvia de; Justino, Maria Cleonice Aguiar; Mascarenhas, Joana D'Arc Pereira; Gabbay, Yvone Benchimol (Wiley, 2013)
      Noroviruses are the leading cause of epidemic, non-bacterial outbreaks of acute gastroenteritis, and are also a major cause of sporadic acute gastroenteritis in infants. The aim of the present study was to identify norovirus ...
    • Norovirus RNA in serum associated with increased fecal viral load in children: detection, quantification and molecular analysis. 

      Reymão, Tammy Kathlyn Amaral; Fumian, Tulio Machado; Justino, Maria Cleonice Aguiar; Hernandez, Juliana Merces; Bandeira, Renato Silva; Lucena, Maria Silvia Sousa; Teixeira, Dielle Monteiro; Farias, Fredison Pinheiro; Silva, Luciana Damascena; Linhares, Alexandre da Costa; Gabbay, Yvone Benchimol (Public Library of Science, 2018)
      Worldwide, norovirus (NoV) is a major cause of acute gastroenteritis (AGE) responsible for pandemics every ~3 years, and over 200,000 deaths per year, with the majority in children from developing countries. We investigate ...
    • Oral live attenuated rotavirus vaccine (RotarixTM) offers a sustained high protection against severe G9P[8] rotavirus gastroenteritis during the first two years of life in Brazilian children 

      Justino, Maria Cleonice Aguiar; Araújo, Eliete C; Doorn, Leen-Jan Van; Oliveira, Consuelo Silva de; Gabbay, Yvone Benchimol; Mascarenhas, Joana D'Arc Pereira; Miranda, Yllen S; Guerra, Sylvia de Fátima dos Santos; Silva, Veronilce B da; Linhares, Alexandre da Costa (Instituto Oswaldo Cruz, 2012)
      In a large Phase III trial conducted in 10 Latin American countries, the safety and efficacy of the live attenuated monovalent rotavirus vaccine RIX4414 was evaluated in 15,183 healthy infants followed up during the first ...
    • Quantitative and molecular analysis of noroviruses RNA in blood from children hospitalized for acute gastroenteritis in Belém, Brazil 

      Fumian, Tulio Machado; Justino, Maria Cleonice Aguiar; Mascarenhas, Joana D'Arc Pereira; Reymão, Tammy K. A; Abreu, Erika; Soares, Luana; Linhares, Alexandre da Costa; Gabbay, Yvone Benchimol (Elsevier, 2013)
      Background: Noroviruses (NoVs) are a common cause of acute gastroenteritis (AGE) and until now, littleis known about its ability to spread outside the gut. Objectives: We aim to investigate the role of NoVs causing viremia ...
    • Rotavirus antigenemia as a common event among children hospitalised for severe, acute gastroenteritis in Belém, northern Brazil 

      Justino, Maria Cleonice Aguiar; Campos, Erika A; Mascarenhas, Joana D'Arc Pereira; Soares, Luana da Silva; Guerra, Sylvia de Fátima dos Santos; Furlaneto, Ismari Perini; Pavão Jr, Manoel Jaime C; Maciel, Tassio S; Farias, Fredison P; Bezerra, Orvácio Melo; Vinente, Caio Breno G; Barros, Rodrigo José S; Linhares, Alexandre da Costa (BioMed Central, 2019)
      Background: Rotavirus antigenemia and RNAemia (the presence of rotavirus RNA in serum) have been commonly identified among paediatric patients with acute gastroenteritis. In this study we examined the association ...
    • Rotavirus serotype distribution in northern Brazil trends over a 27 year period pre and post national vaccine introduction 

      Oliveira, Alessilva; Mascarenhas, Joana D'Arc Pereira; Soares, Luana da Silva; Guerra, Sylvia de Fátima dos Santos; Gabbay, Yvone Benchimol; Sánchez, Nervo; Colindres, Romulo E; Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa (Elsevier, 2012)
      In Brazil, a rotavirus vaccine was included in the public sector in March 2006. In order to identify a possible effect of vaccination on rotavirus strains we evaluated the distribution of serotypes/genotypes in northern ...
    • Rotavirus strain surveillance for three years following the introduction of rotavirus vaccine into Belém, Brazil 

      Guerra, Sylvia de Fátima dos Santos; Linhares, Alexandre da Costa; Mascarenhas, Joana D'Arc Pereira; Oliveira, Alessilva; Justino, Maria Cleonice Aguiar; Soares, Luana da Silva; Müller, Elza Caroline; Brasil, Patrícia; Tuboi, Suely; Ortega-Barria, Eduardo; Colindres, Rómulo (Wiley, 2015)
      The monovalent human rotavirus (RV) vaccine, RIX4414 (Rotarix , GlaxoSmithKline Biologicals) was introduced into Brazil's Expanded Program on Immunization in March 2006. One year after vaccine introduction, the G2P[4] ...
    • Rotavirus vaccination in Brazil : effectiveness and health impact seven years post-introduction 

      Linhares, Alexandre da Costa; Justino, Maria Cleonice Aguiar (Taylor & Francis, 2014)
      Before vaccine introduction in Brazil, rotavirus caused approximately 650,000 outpatient visits, 92,000 hospitalizations and 850 deaths annually among children aged 5 years. Brazil was one of the first countries to introduce ...