Identification of two sublineages of genotype G2 rotavirus among diarrheic children in Parauapebas, Southern Pará State, Brazil
On a world scale, group A human rotaviruses are the most common cause of severe acute gastroenteritis during infancy and childhood, including five (G1, G2, G3, G4, and G9) epidemiologically important genotypes. Among these, ...
G1P 8 Rotavirus in children with severe diarrhea in the post-vaccine introduction era in Brazil: evidence of reassortments and structural modifications of the antigenic VP7 and VP4 regions
Worldwide rotaviruses A (RVA) are responsible for approximately 215,000 deaths annually among children aged <5 years. RVA G1P remains associated with >50% of gastroenteritis cases in this age group. The aim of this study ...
Rotavirus strain surveillance for three years following the introduction of rotavirus vaccine into Belém, Brazil
The monovalent human rotavirus (RV) vaccine, RIX4414 (Rotarix , GlaxoSmithKline Biologicals) was introduced into Brazil's Expanded Program on Immunization in March 2006. One year after vaccine introduction, the G2P ...
Oral live attenuated rotavirus vaccine (RotarixTM) offers a sustained high protection against severe G9P rotavirus gastroenteritis during the first two years of life in Brazilian children
(Instituto Oswaldo Cruz, 2012)
In a large Phase III trial conducted in 10 Latin American countries, the safety and efficacy of the live attenuated monovalent rotavirus vaccine RIX4414 was evaluated in 15,183 healthy infants followed up during the first ...