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Age and environment influences on mouse prion disease progression : behavioral changes and morphometry and stereology of hippocampal astrocytes

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2017
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Age and environment influences on mouse prion disease progression : behavioral changes and morphometry and stereology of hippocampal astrocytes.pdf (5.440xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br//handle/iec/2759
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Torres Neto, João Bento
Sobral, L. L
Reis, R. R
Oliveira, R. B. de
Anthony, Daniel Clive
Vasconcelos, Pedro Fernando da Costa
Diniz, Cristovam Wanderley Picanço
xmlui.dri2xhtml.METS-1.0.item-abstract
Because enriched environment (EE) and exercise increase and aging decreases immune response, we hypothesized that environmental enrichment and aging will, respectively, delay and increase prion disease progression. Mice dorsal striatum received bilateral stereotaxic intracerebral injections of normal or ME7 prion infected mouse brain homogenates. After behavior analysis, animals were euthanized and their brains processed for astrocyte GFAP immunolabeling. Our analysis related to the environmental influence are limited to young adult mice, whereas age influence refers to aged mice raised on standard cages. Burrowing activity began to reduce in ME7-SE two weeks before ME7-EE, while no changes were apparent in ME7 aged mice (ME7-A). Object placement recognition was impaired in ME7-SE, NBH-A, and ME7-A but normal in all other groups. Object identity recognition was impaired in ME7-A. Cluster analysis revealed two morphological families of astrocytes in NBH-SE animals, three in NBH-A and ME7-A, and four in NBH-EE, ME7-SE, and ME7-EE. As compared with control groups, astrocytes from DG and CA3 priondiseased animals show significant numerical and morphological differences and environmental enrichment did not reverse these changes but induced different morphological changes in GFAP+ hippocampal astroglia. We suggest that environmental enrichment and aging delayed hippocampal-dependent behavioral and neuropathological signs of disease progression.
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TORRES NETO, João Bento et al. Age and environment influences on mouse prion disease progression : behavioral changes and morphometry and stereology of hippocampal astrocytes. Oxidative Medicine and Cellular Longevity, v. 2017, n. 4504925, p. 1-18, 2017.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Envelhecimento / fisiologia
Doenças Priônicas / patologia
Doenças Priônicas / psicologia
Astrócitos / patologia
Cérebro / patologia
Hipocampo / patologia
Progressão da Doença
Comportamento Animal
Meio Ambiente
Modelos Animais de Doenças
Imuno-Histoquímica / métodos
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br