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dc.contributor.authorTorres Neto, João Bento-
dc.contributor.authorSobral, L. L-
dc.contributor.authorReis, R. R-
dc.contributor.authorOliveira, R. B. de-
dc.contributor.authorAnthony, Daniel Clive-
dc.contributor.authorVasconcelos, Pedro Fernando da Costa-
dc.contributor.authorDiniz, Cristovam Wanderley Picanço-
dc.date.accessioned2017-09-21T16:57:19Z-
dc.date.available2017-09-21T16:57:19Z-
dc.date.issued2017-
dc.identifier.citationTORRES NETO, João Bento et al. Age and environment influences on mouse prion disease progression : behavioral changes and morphometry and stereology of hippocampal astrocytes. Oxidative Medicine and Cellular Longevity, v. 2017, n. 4504925, p. 1-18, 2017.pt_BR
dc.identifier.issn1942-0994-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/2759-
dc.description.abstractBecause enriched environment (EE) and exercise increase and aging decreases immune response, we hypothesized that environmental enrichment and aging will, respectively, delay and increase prion disease progression. Mice dorsal striatum received bilateral stereotaxic intracerebral injections of normal or ME7 prion infected mouse brain homogenates. After behavior analysis, animals were euthanized and their brains processed for astrocyte GFAP immunolabeling. Our analysis related to the environmental influence are limited to young adult mice, whereas age influence refers to aged mice raised on standard cages. Burrowing activity began to reduce in ME7-SE two weeks before ME7-EE, while no changes were apparent in ME7 aged mice (ME7-A). Object placement recognition was impaired in ME7-SE, NBH-A, and ME7-A but normal in all other groups. Object identity recognition was impaired in ME7-A. Cluster analysis revealed two morphological families of astrocytes in NBH-SE animals, three in NBH-A and ME7-A, and four in NBH-EE, ME7-SE, and ME7-EE. As compared with control groups, astrocytes from DG and CA3 priondiseased animals show significant numerical and morphological differences and environmental enrichment did not reverse these changes but induced different morphological changes in GFAP+ hippocampal astroglia. We suggest that environmental enrichment and aging delayed hippocampal-dependent behavioral and neuropathological signs of disease progression.pt_BR
dc.description.sponsorshipThis study received financial support from Conselho Nacional de Pesquisa (CNPq) (Grant nos. 300203/2010-1 and 471077/2007-0) for Cristovam Wanderley Picanc¸o Diniz; Coordenação de Aperfeiçoamento de Pessoal de Níıvel Superior (CAPES) (Process no. 99999.001533/2014-02) for Cristovam Wanderley Picanço Diniz; and Universidade Federal do Para, Edital PROPESP/FADESP, PIAPA 2015.pt_BR
dc.language.isoengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAge and environment influences on mouse prion disease progression : behavioral changes and morphometry and stereology of hippocampal astrocytespt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryEnvelhecimento / fisiologiapt_BR
dc.subject.decsPrimaryDoenças Priônicas / patologiapt_BR
dc.subject.decsPrimaryDoenças Priônicas / psicologiapt_BR
dc.subject.decsPrimaryAstrócitos / patologiapt_BR
dc.subject.decsPrimaryCérebro / patologiapt_BR
dc.subject.decsPrimaryHipocampo / patologiapt_BR
dc.subject.decsPrimaryProgressão da Doençapt_BR
dc.subject.decsPrimaryComportamento Animalpt_BR
dc.subject.decsPrimaryMeio Ambientept_BR
dc.subject.decsPrimaryModelos Animais de Doençaspt_BR
dc.subject.decsPrimaryImuno-Histoquímica / métodospt_BR
dc.creator.affilliationUniversidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém PA, Brazil.pt_BR
dc.creator.affilliationUniversidade do Estado do Pará. Centro de Ciências da Saúde. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Rio de Janeiro. Health Sciences Center. Biomedical Sciences Institute. Vertebrate Embryology Laboratory. Rio de Janeiro, RJ, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém PA, Brazil.pt_BR
dc.creator.affilliationUniversity of Oxford. Department of Pharmacology. Lab of Experimental Neuropathology. Oxford, UK.en_US
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém PA, Brazil.pt_BR
dc.identifier.doi10.1155/2017/4504925-


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