Cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis in Amazonian Brazil, and the significance of a negative Montenegro skin-test in human infections
Silveira, Fernando Tobias
Shaw, Jeffrey Jon
Souza, Adelson Alcimar Almeida de
Ishikawa, Edna Aoba Yassui
Braga, Roseli Ribeiro
The clinical and epidemiological features of 62 cases of cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis, from Pará State, Amazonian Brazil, are discussed. The parasite, isolated in hamster skin and/or blood-agar culture medium, was in each case identified by both biological characteristics and a monoclonal antibody specific for promastigotes of L. (L.) amazonensis. Of the 62 patients, 46 (74.2 percent) presented with a single cutaneous lesion, and on no occasion was evidence found indicating metastatic spread to either the naso-pharyngeal mucosae or the viscera. Recent claims that this parasite may be responsible for both mucocutaneous leishmaniasis and typical visceral leishmaniasis are discussed. Meglumine antimoniate (Glucantime) proved highly efficient in the treatment of all patients. Of the 62 patients examined by the Montenegro skin test, only 32 (51.6 percent) gave a positive reaction. The significance of this finding is considered and the hypothesis made that the parasite itself may induce an immunoinhibition. Field studies amply confirmed the role of Lutzomyia flaviscutellata as the major sandfly vector of L. (L.) amazonensis in Amazonia.
xmlui.dri2xhtml.METS-1.0.item-citationSILVEIRA, Fernando Tobias et al. Cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis in Amazonian Brazil, and the significance of a negative Montenegro skin-test in human infections. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 85, n. 6, p. 735-738, Nov.-Dec. 1991.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryLeishmaniose Cutânea / transmissão
Leishmaniose Cutânea / parasitologia
Meglumina / uso terapêutico