• Portal do Governo Brasileiro
  • Atualize sua Barra de Governo
Logo
    • English
    • español
    • português (Brasil)
    • English
    • español
    • português (Brasil)
  • xmlui.dri2xhtml.structural.login
xmlui.ArtifactBrowser.ItemViewer.trail 
  •   xmlui.general.dspace_home
  • SEÇÃO DE BACTERIOLOGIA E MICOLOGIA
  • SABMI - Artigos Científicos
  • xmlui.ArtifactBrowser.ItemViewer.trail
  •   xmlui.general.dspace_home
  • SEÇÃO DE BACTERIOLOGIA E MICOLOGIA
  • SABMI - Artigos Científicos
  • xmlui.ArtifactBrowser.ItemViewer.trail
JavaScript is disabled for your browser. Some features of this site may not work without it.

Genetic diversity of Mycobacterium tuberculosis from Pará, Brazil, reveals a higher frequency of ancestral strains than previously reported in South America

Thumbnail
xmlui.dri2xhtml.METS-1.0.item-date
2017
xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
Genetic diversity of Mycobacterium tuberculosis from Pará, Brazil, reveals a higher frequency of ancestral strains than previously reported in South America.pdf (85.97xmlui.dri2xhtml.METS-1.0.size-kilobytes)
xmlui.mirage2.itemSummaryView.MetaData
xmlui.ArtifactBrowser.ItemViewer.show_full
xmlui.dri2xhtml.METS-1.0.item-uri
http://patua.iec.gov.br//handle/iec/2831
xmlui.dri2xhtml.METS-1.0.item-author
Conceição, Emilyn Costa
Rastogi, Nalin
Couvin, David
Lopes, Maria Luíza
Furlaneto, Ismari Perini
Gomes, Harrison Magdinier
Vasconcellos, Sidra Ezídio Gonçalves
Suffys, Philip Noel
Schneider, Maria Paula Cruz
Sousa, Maísa Silva de
Sola, Christophe
Guimarães, Ricardo José de Paula Souza e
Duarte, Rafael Silva
Lima, Karla Valéria Batista
xmlui.dri2xhtml.METS-1.0.item-abstract
There is only scarce information available on genotypic diversity of the Mycobacterium tuberculosis complex (MTBC) clinical isolates circulating in the Northern part of Brazil, a relatively neglected region regarding research on tuberculosis. We therefore characterized 980 MTBC clinical isolates from the state of Pará, by spoligotyping and data was compared with patterns from around the world, besides analyzing drug susceptibility, and collecting sociodemographic data. We also performed 24 loci MIRU-VNTR typing to evaluate phylogenetic inferences among the East-African-India (EAI) lineage strains. The Geographic Information System analyses were performed to generate a descriptive visualization of MTBC strain distribution in the region. A total of 249 different spoligopatterns primarily belonging to evolutionary recent Euro-American lineages, as well as Central-Asian, Manu and ancestral EAI lineages, were identified, in addition to strains with reportedly unknown lineage signatures. The most frequent lineages were Latin American Mediterranean, T and Haarlem. Interestingly, EAI lineage strains were found in a higher proportion in a significantly higher proportion in comparison with previous studies from South America. Regarding EAI lineage, the absence of spacers 4–9 and 23–24 co-related to 24 loci MIRU-VNTRs may suggest a close evolutionary relationship between such strains in Pará and those prevalent in Mozambique, which might have contributed to the genetic diversity of MTBC strains in this region.
xmlui.dri2xhtml.METS-1.0.item-citation
CONCEIÇÃO, Emilyn Costa et al. Genetic diversity of Mycobacterium tuberculosis from Pará, Brazil, reveals a higher frequency of ancestral strains than previously reported in South America. Infection, Genetics and Evolution, v. 56, p. 62–74, Dec. 2017.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Mycobacterium tuberculosis
Tuberculose / diagnóstico
Variação Genética
Linhagem Celular
xmlui.dri2xhtml.METS-1.0.item-rights
Acesso Embargado
xmlui.mirage2.itemSummaryView.Collections
  • PCS - Artigos Científicos
  • SABMI - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

xmlui.ArtifactBrowser.Navigation.head_browse

xmlui.ArtifactBrowser.Navigation.head_all_of_dspacexmlui.ArtifactBrowser.Navigation.communities_and_collectionsxmlui.ArtifactBrowser.Navigation.browse_dateissuedxmlui.ArtifactBrowser.Navigation.browse_authorxmlui.ArtifactBrowser.Navigation.browse_titlexmlui.ArtifactBrowser.Navigation.browse_subjectxmlui.ArtifactBrowser.Navigation.head_this_collectionxmlui.ArtifactBrowser.Navigation.browse_dateissuedxmlui.ArtifactBrowser.Navigation.browse_authorxmlui.ArtifactBrowser.Navigation.browse_titlexmlui.ArtifactBrowser.Navigation.browse_subject

xmlui.EPerson.Navigation.my_account

xmlui.EPerson.Navigation.loginxmlui.EPerson.Navigation.register

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br