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dc.contributor.authorFalcão, Aline Semblano Carreira-
dc.contributor.authorVasconcelos, Pedro Fernando da Costa-
dc.contributor.authorSilva, Dorotéa de Fátima Lobato da-
dc.contributor.authorPinheiro, João de Jesus Viana-
dc.contributor.authorFalcão, Luiz Fábio Magno-
dc.contributor.authorQuaresma, Juarez Antonio Simões-
dc.date.accessioned2017-12-05T14:09:01Z-
dc.date.available2017-12-05T14:09:01Z-
dc.date.issued2017-
dc.identifier.citationFALCÃO, Aline Semblano Carreira et al. Mechanisms of human cytomegalovirus infection with a focus on epidermal growth factor receptor interactions. Reviews in Medical Virology, v. 27, n. 6, Nov. 2017.pt_BR
dc.identifier.issn1052-9276-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/2908-
dc.description.abstractHuman cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe diseases in immunocompromised individuals. It has a high prevalence worldwide that is linked with socioeconomic factors. Similar to other herpesviruses, HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. HCMV infects a broad range of cell types. This broad tropism suggests that it may use multiple receptors for host cell entry. The identification of receptors used by HCMV is essential for understanding viral pathogenesis, because these receptors mediate the early events necessary for infection. Many cell surface components have been identified as virus receptors, such as epidermal growth factor receptor (EGFR), which is characterized by tyrosine kinase activity and plays a crucial role in the control of key cellular transduction pathways. EGFR is essential for HCMV binding, signaling, and host cell entry. This review focuses on HCMV infection via EGFR on different cell types and its implications for the cellular environment, viral persistence, and infection.pt_BR
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMechanisms of human cytomegalovirus infection with a focus on epidermal growth factor receptor interactionspt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryCitomegalovirus / patogenicidadept_BR
dc.subject.decsPrimaryInfecções por Citomegaloviruspt_BR
dc.subject.decsPrimaryFator de Crescimento Epidérmicopt_BR
dc.subject.decsPrimaryInfecções por Vírus de DNApt_BR
dc.subject.decsPrimaryReceptores de Superfície Celularpt_BR
dc.subject.decsPrimaryTransdução de Sinaispt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Divisão de Doenças Infecciosas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Virologia e Biologia Molecular. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFederal University of Pará. School of Dentistry. Department of Oral and Maxillofacial Pathology. Belém, PA, Brazil / University of São Paulo. Institute of Biomedical Sciences. Department of Cell and Developmental Biology. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationPará State University. Center for Biological Sciences and Health. Belém, PA, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Divisão de Doenças Infecciosas. Ananindeua, PA, Brasil / Pará State University. Center for Biological Sciences and Health. Belém, PA, Brazil / Federal University of Pará. Tropical Medicine Center. Division of Infectious Diseases. Belém, PA, Brazil.pt_BR
dc.identifier.doi10.1002/rmv.1955-


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