• Serum soluble mediator profiles and networks during acute infection with distinct DENV serotypes 

  Silva, Mikelly Santos Coutinho da; Sucupira, Pedro Henrique Ferreira; Bicalho, Kelly Alves; Campi-Azevedo, Ana Carolina; Sousa, Joaquim Pedro Brito de; Magalhães, Vanessa Peruhype; Rios, Maria; Carvalho, Andréa Teixeira; Reis, Jordana Grazziela Alves Coelho dos; Antonelli, Lis Ribeiro do Valle; Rezende, Vitor Bortolo de; Melo, Fernanda Ludolf Ribeiro de; Garcia, Cristiana Couto; Andradre, Jesuanne Carla Silva; Rocha, Ismael Artur da Costa; Bastos, Michele de Souza; Rocha, Lucia Alves da; Silva, Valderjane Aprigio; Ferreira, Ewerton da Silva; Marinho, Eveny Perlize Melo; Costa, Allyson Guimarães; Gomes, Matheus de Souza; Amaral, Laurence Rodrigues; Furtado, Erilene Cristina da Silva; Silva, Eliana Vieira Pinto da; Ramos, Bruna Alves; Santos, Éder Barros dos; Freitas, Maria de Nazaré Oliveira; Vasconcelos, Pedro Fernando da Costa; Martins Filho, Olindo Assis; Araújo, Márcio Sobreira Silva; Ferreira, Milene Silveira; Martins, Lívia Carício (Frontiers Media, 2022)

  A panoramic analysis of chemokines, pro-inflammatory/regulatory cytokines, and growth factors was performed in serum samples from patients with acute DENV infection (n=317) by a high-throughput microbeads array. Most soluble ...

• Discovery and genome sequencing of a new virus related to members of the family Tymoviridae, isolated from mosquitoes of the genus Mansonia in Brazil 

  Miranda, Keissy Karoline Pinheiro; Galvão, Glennda Juscely Pereira; Araújo, Pedro Arthur da Silva; Ribeiro, Ana Claudia da Silva; Silva, Sandro Patroca da; Lemos, Poliana da Silva; Martins, Lívia Carício; Nunes, Márcio Roberto Teixeira; Vasconcelos, Pedro Fernando da Costa; Ferreira, Vânia da Costa; Costa, Fábio Medeiros da; Roque, Rosemary Aparecida; Tadei, Wanderli Pedro; Cruz, Ana Cecília Ribeiro; Carvalho, Valéria Lima (Springer, 2022)

  A new virus, named Mutum virus, related to members of the family Tymoviridae, was isolated from mosquitoes (Mansonia spp.) in clone C6/36 cells, and its complete genome was sequenced. Its genome is 6494 nt in size with an ...

• Description of mitochon genome and phylogenetic considerations of Sabethes bipartipes, Sabethes cyaneus, Sabethes quasicyaneus, and Sabethes tarsopus (Diptera: Culicidae) 

  Aragão, Andressa de Oliveira; Silva, Fábio Silva da; Cruz, Ana Cecília Ribeiro; Silva, Sandro Patroca da; Medeiros, Daniele Barbosa de Almeida; Dias, Daniel Damous; Nascimento, Bruna Laís Sena do; Rosa Júnior, José Wilson; Monteiro, Hamilton Antônio de Oliveira; Nunes Neto, Joaquim Pinto (Elsevier, 2022)

  The genus Sabethes (Diptera: Culicidae) comprises species of great epidemiological relevance, particularly involved in transmission cycles of the Yellow fever virus in South America. Given the unavailability of information ...

• Description of the mitogenome and phylogeny of Aedes spp. (Diptera: Culicidae) from the Amazon region 

  Silva, Lucas Henrique da Silva e; Silva, Fábio Silva da; Medeiros, Daniele Barbosa de Almeida; Cruz, Ana Cecília Ribeiro; Silva, Sandro Patroca da; Aragão, Andressa de Oliveira; Dias, Daniel Damous; Nascimento, Bruna Laís Sena do; Rosa Júnior, José Wilson; Vieira, Durval Bertram Rodrigues; Monteiro, Hamilton Antônio de Oliveira; Nunes Neto, Joaquim Pinto (Elsevier, 2022)

  The genus Aedes (Diptera: Culicidae) includes species of great epidemiological relevance, particularly involved in transmission cycles of leading arboviruses in the Brazilian Amazon region, such as the Zika virus (ZIKV), ...

• Absence of anti-RBD antibodies in SARS-CoV-2 infected or naive individuals prior to vaccination with CoronaVac leads to short protection of only four months duration 

  Oliveira, Camille F. de; F. Neto, Walter F; Silva, Carla P. da; Ribeiro, Ana Claudia Santos; Martins, Lívia Carício; Sousa, Alana W. de; Freitas, Maria N. O; Chiang, Jannifer Oliveira; Silva, Franko A; Santos, Eder B. dos; Medeiros, Daniele Barbosa de Almeida; Pinheiro, Gleiciane S; Brandão, Gleiciane F; Carvalho, Valéria Lima; Azevedo, Raimunda do Socorro da Silva; Vasconcelos, Pedro Fernando da Costa; Costa, Igor Brasil; Costa, Iran Barros; Santos, Mirleide Cordeiro dos; Soares, Luana da Silva; Bedran, Rayssa L. S; Ferreira, James L; Amarilla, Alberto A; Modhiran, Naphak; McMillan, Christopher L. D; Freney, Morgan E; Muller, David A; Watterson, Daniel; Casseb, Lívia Medeiros Neves; Henriques, Daniele Freitas (MDPI, 2022)

  Abstract: The COVID-19 pandemic is the biggest public health threat facing the world today. Multiple vaccines have been approved; however, the emergence of viral variants such as the recent Omicron raises the possibility ...

• Single cell multiomic approaches to disentangle T cell heterogeneity 

  Abondio, Paolo; Intinis, Carlo de; Vianez Júnior, João Lídio da Silva Gonçalves; Pace, Luigia (Elsevier, 2022)

  Single-cell multi-omics is a rapidly evolving field, thanks to a fast technological improvement and the growing accuracy of dedicated computational tools for data analysis. Its importance is highlighted by the possibility ...

• Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil 

  Aromolaran, Adeolu; Araujo, Katiaci; Ladines-Lim, Joseph B; Nery Jr, Nivison; Rosário, Mateus S. do; Rastely Jr, Valmir N; Archanjo, Gracinda; Daltro, Dina; Carvalho, Gustavo Baltazar da Silveira; Pimentel, Kleber; Almeida, João Ricardo Maltez de; Siqueira, Isadora Cristina de; Ribeiro, Hugo C; Oliveira Filho, Jamary; Oliveira, Daiana de; Henriques, Daniele Freitas; Rodrigues, Sueli Guerreiro; Vasconcelos, Pedro Fernando da Costa; Almeida, Antonio R. P. de; Sacramento, Gielson A; Cruz, Jaqueline S; Sarno, Manoel; Freitas, Bruno de Paula; Mattos, Adriana; Khouri, Ricardo; Reis, Mitermayer Galvão dos; Ko, Albert I; Costa, Federico (Elsevier, 2022)

  Objectives: To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals in Salvador, Brazil that serve patients of different ...

• Was It Chikungunya? Laboratorial and clinical investigations of cases occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil 

  Souza, Thiara Manuele Alves de; Lima, Raquel Curtinhas de; Solórzano, Victor Edgar Fiestas; Damasco, Paulo Vieira; Souza, Luiz José de; Arcila, Juan Camilo Sanchez; Guimarães, Gabriel Macedo Costa; Paiva, Iury Amâncio; Lima, Monique da Rocha Queiroz; Nogueira, Fernanda de Bruycker; Tomé, Larissa Cristina Teixeira; Coelho, Mariana Rosa Inácio; Silva, Sandro Patroca da; Pinto, Luiza Maria de Oliveira; Azeredo, Elzinandes Leal de; Santos, Flavia Barreto dos (MDPI, 2022)

  The co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and ...

• Phylogeny of Anopheles darlingi (Diptera:Culicidae) based on the antimicrobial peptide genes cecropin and defensin 

  Santos, Erian de Almeida; Santos, Ana Cecília Feio dos; Silva, Fábio Silva da; Queiroz, Alice Louize Nunes; Pires, Luciana Letícia da Costa; Casseb, Samir Mansour Moraes; Holanda, Gustavo Moraes; Sucupira, Izis Mônica Carvalho; Cruz, Ana Cecília Ribeiro; Santos, Eduardo José Melo dos; Póvoa, Marinete Marins (Elsevier, 2022)

  Cecropins and defensins are the main classes of antimicrobial peptides in the mosquito innate immune system, acting against bacteria, fungi and protozoa. There is a knowledge gap concerning these peptide genes in anopheline ...

• Biological characterization of yellow fever viruses isolated from non-human primates in Brazil with distinct genomic landscapes 

  Furtado, Nathália Dias; Raphael, Lidiane de Menezes; Ribeiro, Ieda Pereira; Mello, Iasmim Silva de; Fernandes, Déberli Ruiz; Gómez, Mariela Martínez; Santos, Alexandre Araújo Cunha dos; Nogueira, Mônica da Silva; Castro, Márcia Gonçalves de; Abreu, Filipe Vieira Santos de; Martins, Lívia Carício; Vasconcelos, Pedro Fernando da Costa; Oliveira, Ricardo Lourenço de; Bonaldo, Myrna Cristina (Frontiers Media, 2022)

  Since the beginning of the XXI Century, the yellow fever virus (YFV) has been cyclically spreading from the Amazon basin to Brazil’s South and Southeast regions, culminating in an unprecedented outbreak that started in ...

• Arbovirus outbreak in a rural region of the Brazilian Amazon 

  Carvalho, Vanessa Lima; Azevedo, Raimunda do Socorro da Silva; Carvalho, Valéria Lima; Azevedo, Rafael da Silva; Henriques, Daniele Freitas; Cruz, Ana Cecília Ribeiro; Vasconcelos, Pedro Fernando da Costa; Martins, Livia Carício (Elsevier, 2022)

  Background: An outbreak of febrile illness was reported from January to February 2018 in the Expedito Ribeiro Settlement, ​​Santa Bárbara do Pará municipality, Pará State, Brazil. Objective: This study aimed to investigate ...

• The first evidence of hepatitis A virus subgenotype IIIA in the Eastern Brazilian Amazon, 1982-1983 

  Moreira, Luiz Vinícius Leão; Malheiros, Andreza Pinheiro; Barbosa, Kemere Marques Vieira; Freitas, Pedro Eduardo Bonfim; Silva, Andrea Lima; Cruz, Ana Cecília Ribeiro; Nunes, Heloisa Marceliano; Chagas, Andre Antonio Correa das; Souza, Alex Júnior Souza de (Wiley, 2022)

  Hepatitis A virus (HAV) is a major causative agent of acute hepatitis worldwide. Although discovered in 1973, due to limitations of applicable serological and/or molecular methods, HAV remained under limited diagnosis until ...

• Negeviruses isolated from mosquitoes in the Brazilian Amazon 

  Ribeiro, Ana Cláudia da Silva; Martins, Lívia Caricio; Silva, Sandro Patroca da; Medeiros, Daniele Barbosa de Almeida; Miranda, Keissy Karoline Pinheiro; Nunes Neto, Joaquim Pinto; Monteiro, Hamilton Antônio de Oliveira; Nascimento, Bruna Lais Sena do; Rosa Junior, José Wilson; Cruz, Ana Cecília Ribeiro; Vasconcelos, Pedro Fernando da Costa; Carvalho, Valéria Lima; Rodrigues, Sueli Guerreiro (BMC, 2022)

  Background: There are several groups of viruses including Insect Specific Viruses (ISV) such as the taxon Negevirus, a group of viruses phylogenetically related to plant viruses. Negeviruses replicate in mosquito cells, ...

• Endothelium activation during severe yellow fever triggers an intense cytokine-mediated inflammatory response in the liver parenchyma 

  Olímpio, Fábio Alves; Falcão, Luiz Fábio Magno; Carvalho, Marcos Luiz Gaia; Lopes, Jeferson da Costa; Mendes, Caio Cesar Henriques; Martins Filho, Arnaldo Jorge; Silva, Carlos Augusto Moreira da; Miranda, Vanessa do Socorro Cabral; Santos, Lais Carneiro dos; Vilacoert, Fellipe Souza da Silva; Cruz, Ana Cecília Ribeiro; Galúcio, Vanessa Costa Alves; Azevedo, Raimunda do Socorro da Silva; Martins, Lívia Caricio; Duarte, Maria Irma Seixas; Sousa, Jorge Rodrigues de; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões (MDPI, 2022)

  Yellow fever (YF) is a pansystemic disease caused by the yellow fever virus (YFV), the prototype species of the family Flaviviridae and genus Flavivirus, and has a highly complex host-pathogen relationship, in which ...

• Whole-genome sequencing of Leishmania infantum chagasi isolates from Honduras and Brazil 

  Silveira, Fernando Tobias; Sousa Junior, Edivaldo Costa; Silvestre, Rodrigo Vellasco Duarte; Martins, André Guilherme Costa; Pinheiro, Kenny da Costa; Ochoa, Wilfredo Sosa; Santos, Thiago Vasconcelos dos; Ramos, Patrícia Karla; Casseb, Samir Mansour Moraes; Silva, Sandro Patroca da; Valeriano, Concepción Zúniga; Lima, Luciana Vieira; Campos, Marliane Batista; Matta, Vania Lucia da; Gomes, Claudia Maria; Flores, Gabriela Venicia; Pacheco, Carmen Maria; Corbett, Carlos Eduardo; Nakaya, Helder; Laurenti, Márcia Dalastra (American Society for Microbiology, 2021)

  This work reports on the whole-genome sequencing of Leishmania infantum chagasi from Honduras (Central America) and Brazil (South America).

• Unwanted exacerbation of the immune response in neurodegenerative disease: a time to review the impact 

  Leite, Amanda de Oliveira Ferreira; Torres Neto, João Bento; Reis, Renata Rodrigues dos; Sobral, Luciane Lobato; Souza, Aline Cristine Passos de; Trévia, Nonata; Oliveira, Roseane Borner de; Lins, Nara Alves de Almeida; Diniz, Daniel Guerreiro; Diniz, José Antônio Picanço; Vasconcelos, Pedro Fernando da Costa; Anthony, Daniel Clive; Brites, Dora; Diniz, Cristovam Wanderley Picanço (Frontiers Media, 2021)

  The COVID-19 pandemic imposed a series of behavioral changes that resulted in increased social isolation and a more sedentary life for many across all age groups, but, above all, for the elderly population who are the most ...

• First description of the mitogenome and phylogeny of culicinae species from the Amazon Region 

  Nascimento, Bruna Laís Sena do; Silva, Fábio Silva da; Nunes Neto, Joaquim Pinto; Medeiros, Daniele Barbosa de Almeida; Cruz, Ana Cecília Ribeiro; Silva, Sandro Patroca da; Silva, Lucas Henrique da Silva e; Monteiro, Hamilton Antônio de Oliveira; Dias, Daniel Damous; Vieira, Durval Bertram Rodrigues; Rosa Jr, José Wilson; Brandão, Roberto Carlos Feitosa; Chiang, Jannifer Oliveira; Martins, Livia Carício; Vasconcelos, Pedro Fernando da Costa (MDPI, 2021)

  The Culicidae family is distributed worldwide and comprises about 3587 species subdivided into the subfamilies Anophelinae and Culicinae. This is the first description of complete mitochondrial DNA sequences from Aedes ...

• Occurrence of tick-borne diseases in domestic dogs in Belém, Pará, Brazil 

  Guimarães, Mylenna de Cássia Neves; Silva, Pâmela Talita de Aguiar e; Monteiro, Thamillys Rayssa Marques; Santos, Camile de Cássia dos; Costa, Jacqueline Corrêa; Valente, Keila Feitosa; Silva, Barbara Wilka Leal; Casseb, Alexandre do Rosário; Casseb, Livia Medeiros Neves (Universidade Federal Rural do Semi-Árido, 2021)

  Tick-borne blood cell pathogens, which are challenging to diagnose, are primarily detected using molecular techniques. Therefore, this study aimed to detect the main infectious agents involved in 50 cases of suspected ...

• Whole-genome sequencing of alcaligenes faecalis HZ01, with potential to inhibit nontuberculous mycobacterial growth 

  Fernandes, Henry Marcel Zolona; Conceição, Emilyn Costa; Silva, Sandro Patroca da; Machado, Edson; Sisco, Maria Carolina; Sharma, Abhinav; Lima, Karla Valéria Batista; Conceição, Marília Lima da; Carvalho, Ana Carolina da Silva; Miranda, Karla Rodrigues; Duarte, Rafael Silva; Alviano, Daniela Sales; Dias, Rubens Clayton da Silva (American Society for Microbiology, 2021)

  Alcaligenes faecalis is a Gram-negative rod that is ubiquitous in the environment and is an opportunistic human pathogen. Here, we report the whole-genome sequencing analysis of A. faecalis HZ01, which presents mycobacterial ...

• Molecular diagnosis and clinicopathological characteristics of canine distemper neurologic disease 

  Jesus, I. S; Cruz, A. V; Santos, C. M. P; Barra, E. C. M; Costa, J. C; Monteiro, T. R. M; Santos, C. C; Valente, K. F; Silva, B. W. L; Rodrigues, E. D. L; Almeida, J. C. F; Silva Filho, E; Figueiredo, M. J. F. M; Sousa, S. K. S. A; Silva, S. P; Casseb, Livia Medeiros Neves; Negrão, A. M. G; Casseb, A. R (FUNPEC-EDITORA, 2021)

  Canine distemper is a highly infectious disease, distributed throughout the world. It is characterized by lymphotropism, neurotropism, and epitheliotropism, resulting in severe clinical changes and death. We report on the ...

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