• Experimental yellow fever virus infection in the squirrel monkey (Saimiri spp.) I: gross anatomical and histopathological findings in organs at necropsy 

  Ferreira, Milene Silveira; Bezerra Junior, Pedro Soares; Cerqueira, Valíria Duarte; Rivero, Gabriela Riet Correa; Oliveira Junior, Carlos Alberto; Castro, Paulo Henrique Gomes; Silva, Gilmara Abreu da; Silva, Wellington Bandeira da; Imbeloni, Aline Amaral; Sousa, Jorge Rodrigues; Araújo, Ana Paula Sousa; Silva, Franko de Arruda e; Tesh, Robert B; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Instituto Oswaldo Cruz, 2020)

  BACKGROUND Non-human primates contribute to the spread of the yellow fever virus (YFV) and the establishment of transmission cycles in endemic areas. OBJECTIVE To describe the severe histopathological aspects of YFV ...

• Mitochondrial genome sequencing and phylogeny of Haemagogus albomaculatus, Haemagogus leucocelaenus, Haemagogus spegazzinii, and Haemagogus tropicalis (Diptera: Culicidae) 

  Silva, Fábio Silva da; Cruz, Ana Cecília Ribeiro; Medeiros, Daniele Barbosa de Almeida; Silva, Sandro Patroca da; Nunes, Márcio Roberto Teixeira; Martins, Lívia Carício; Chiang, Jannifer Oliveira; Lemos, Poliana da Silva; Cunha, Gabriel Muricy; Araujo, Renato Freitas de; Monteiro, Hamilton Antônio de Oliveira; Nunes Neto, Joaquim Pinto (Nature Research, 2020)

  The genus Haemagogus (Diptera: Culicidae) comprises species of great epidemiological relevance, involved in transmission cycles of the Yellow fever virus and other arboviruses in South America. So far, only Haemagogus ...

• Evaluation of immunoglobulin M-specific capture enzyme-linked immunosorbent assays and commercial tests for flaviviruses diagnosis by a National Reference Laboratory 

  Henriques, Daniele Freitas; Nunes, Juliana A. L; Anjos, Maura V; Melo, Juliana M; Rosário, Wallace O; Azevedo, Raimunda do Socorro da Silva; Chiang, Jannifer Oliveira; Martins, Livia Carício; Santos, Flavia B. dos; Casseb, Livia Medeiros Neves; Vasconcelos, Pedro Fernando da Costa; Rodrigues, Sueli Guerreiro (Elsevier, 2020)

  Zika and Dengue viruses present considerable immunological cross-reactivity, resulting in a troublesome serodiagnosis due to occurrence of false positive results. Due to Brazil’s wide variety of circulating flaviviruses ...

• Characterization of Mycobacterium tuberculosis var. africanum isolated from a patient with pulmonary tuberculosis in Brazil 

  Rabahi, Marcelo Fouad; Conceição, Emilyn Costa; Paiva, Luísa Oliveira de; Souto, Marcos Vinícius Muniz Lemes; Sisco, Maria Carolina; Waard, Jacobus de; Caldas, Paulo Cesar de Souza; Fandinho, Fatima; Ramos, Jesus Pais; Carvalho, Luciana Distasio de; Campos, Carlos Eduardo Dias; Lima, Karla Valéria Batista; Silva, Sandro Patroca da; Sharma, Abhinav; Robledo, Jaime; Paez, Uriel Alonso Hurtado; Duarte, Rafael Silva; Silva, Marlei Gomes da; Gomes, Lia Lima; Vasconcellos, Sidra Ezidio Gonçalves; Uwezeye, Cecile; Jong, Bouke C. de; Junqueira-Kipnis, Ana Paula; Suffys, Philip Noel (Elsevier, 2020)

  Human tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC), including Mycobacterium tuberculosis var. tuberculosis (MTB) and Mycobacterium tuberculosis var. africanum (MAF). While MTB is ...

• The innate immune response in Zika virus infection 

  Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Wiley, 2020)

  Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes ...

• Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon 

  Oliveira, Consuelo Silva de; Matos, Haroldo José de; Ramos, Francisco Lúzio de Paula; Pinto, Ana Yecê das Neves; Graim, Priscila Nathyelly dos S; Guimarães, Vivianne de Paula R; Gomes, Luna Thaís S; Serra, Emilene M. F; Cruz, Ana Cecília Ribeiro; Leal, Alessandra; Henriques, Daniele Freitas; Lima, Juliana A; Anjos, Maura V; Pinto, Eliana Vieira Pinto da; Souza, Alana W. de; Vasconcelos, Pedro Fernando da Costa (Pan American Health Organization, 2020)

  Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected ...

• Chikungunya virus detection in Aedes aegypti and Culex quinquefasciatus during an outbreak in the Amazon Region 

  Cruz, Ana Cecília Ribeiro; Nunes Neto, Joaquim Pinto; Silva, Sandro Patroca da; Silva, Eliana Vieira Pinto da; Pereira, Glennda Juscely Galvão; Santos, Maissa Maia; Monteiro, Hamilton Antônio de Oliveira; Santos, Flavia Barreto dos; Guimarães, Ricardo José de Paula Souza e; Aragão, Carine Fortes; Martins, Lívia Carício (MDPI, 2020)

  Chikungunya virus (CHIKV) was first reported in Brazil in 2014 and, after it spread countrywide, an outbreak of febrile illness with reports of arthralgia happened in the municipality of Xinguara, Pará, Brazil in 2017, ...

• Seguimento de crianças expostas intraútero ao vírus Zika na Região Metropolitana de Belém, Pará, Brasil 

  Oliveira, Consuelo Silva de; Matos, Haroldo José de; Gomes, Luna Thais Sousa; Serra, Emilene Monteiro Furtado; Fraiha, Marcela Cruz; Nunes, Déborah Silva (MS/SVS/Instituto Evandro Chagas, 2020)

  INTRODUÇÃO: A emergência do vírus Zika (ZIKV), que afetou gravemente o nordeste do Brasil, revelou a ocorrência de malformações congênitas durante a gestação. Atualmente, têm sido registradas alterações que envolvem ...

• Zika structural genes determine the virulence of African and Asian lineages 

  Nunes, Bruno Tardelli Diniz; Fontes-Garfias, Camila R; Shan, Chao; Muruato, Antonio E; Nunes, Jannyce G. C; Burbano, Rommel M. R; Vasconcelos, Pedro Fernando da Costa; Shi, Pei-Yong; Medeiros, Daniele Barbosa de Almeida (Taylor & Francis, 2020)

  The Asian lineage of Zika virus (ZIKV) is responsible for the recent epidemics in the Americas and severe disease, whereas the African lineage of ZIKV has not been reported to cause epidemics or severe disease. We constructed ...

• Using next generation sequencing to study the genetic diversity of candidate live attenuated zika vaccines 

  Collins, Natalie D; Shan, Chao; Nunes, Bruno Tardelli Diniz; Widen, Steven G; Shi, Pei-Yong; Barrett, Alan D. T; Sarathy, Vanessa V (MDPI, 2020)

  Abstract: Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Candidate live-attenuated vaccine (LAV) viruses with engineered deletions in the 3’ untranslated region (UTR) ...

• Phylogenomic perspective on a unique mycobacterium bovis clade dominating bovine tuberculosis infections among cattle and buffalos in Northern Brazil 

  Conceição, Marília Lima da; Conceição, Emilyn Costa; Furlaneto, Ismari Perini; Silva, Sandro Patroca da; Guimarães, Arthur Emil dos Santos; Gomes, Pedro; Boschiroli, María Laura; Michelet, Lorraine; Kohl, Thomas Andreas; Kranzer, Katharina; Francez, Loreno da Costa; Lima, Luana Nepomuceno Gondim Costa; Portugal, Isabel; Perdigão, João; Lima, Karla valéria Batista (Nature Research, 2020)

  Lack of routine surveillance in countries endemic for bovine tuberculosis (TB) and limited laboratory support contributes to the inability to differentiate the Mycobacterium tuberculosis Complex species, leading to an ...

• Ecological aspects of potential arbovirus vectors (Diptera: Culicidae) in an urban landscape of Southern Amazon, Brazil 

  Vieira, Carla Julia da Silva Pessoa; Thies, Sirlei Franck; Silva, David José Ferreira da; Kubiszeski, Janaína Rigotti; Barreto, Eriana Serpa; Monteiro, Hamilton Antônio de Oliveira; Mondini, Adriano; Bernardo, Christine Steiner São; Bronzoni, Roberta Vieira de Morais (Elsevier, 2020)

  Amazon has been under intense human pressure, especially in the so-called “Arc of Deforestation” in the Eastern and Southern regions. Changes in biodiversity due to landscape disturbance in municipalities at the Arc of ...

• Callithrix penicillata: a feasible experimental model for dengue virus infection 

  Ferreira, Milene Silveira; Castro, Paulo Henrique Gomes de; Silva, Gilmara Abreu; Casseb, Samir Mansur Moraes; Dias Júnior, Antônio Gregório; Rodrigues, Sueli Guerreiro; Azevedo, Raimunda do Socorro da Silva; Silva, Matheus Fernandes Costa e; Zauli, Danielle Alves Gomes; Araújo, Márcio Sobreira Silva; Béla, Samantha Ribeiro; Carvalho, Andréa Teixeira; Martins Filho, Olindo Assis; Vasconcelos, Pedro Fernando da Costa (Elsevier, 2014)

  Although the murine models have the feasibility to reproduce some signs of dengue Virus (DENV) infection, the use of isogenic hosts with polarized immune response patterns does not reproduce the particularities of human ...

• Yellow fever virus: historical and current issues regarding recent epidemics and vaccination in Brazil 

  Ishak, Ricardo; Ishak, Marluísa de Oliveira Guimarães; Vallinoto, Antonio Carlos Rosário; Pinheiro, Francisco de Paula (Taylor & Francis, 2020)

  Yellow fever has been recently described in nonurban areas of Brazil despite 80 years of commercial vaccine use. Although the disease does not spread fear in the general population as it did in the past, yellow fever virus ...

• Upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in renal tissue in severe dengue in humans: Effects on endothelial activation/dysfunction 

  Vitoria, Webster Oliveira; Thomé, Letícia Silva; Kanashiro-Galo, Luciane; Carvalho, Leda Viegas de; Penny, Ricardo; Santos, Washington Luis Conrado; Vasconcelos, Pedro Fernando da Costa; Sotto, Mirian Nacagami; Duarte, Maria Irma Seixas; Quaresma, Juarez Antonio Simões; Pagliari, Carla (Sociedade Brasileira de Medicina Tropical, 2019)

  INTRODUCTION: Dengue is an important mosquito-borne disease in tropical and subtropical regions. Adhesion molecules have not been systematically characterized in the renal tissue of patients with severe dengue (SD). The ...

• IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters 

  Oliveira, Euzébio de; Azevedo, Raimunda do Socorro Silva; Coelho-dos-Reis, Jordana Grazziela; Antonelli, Lis Ribeiro do Valle; Ferreira, Milene Silveira; Campi-Azevedo, Ana Carolina; Costa-Silva, Matheus Fernandes; Martins, Lívia Carício; Chiang, Jannifer Oliveira; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis; Vasconcelos, Pedro Fernando da Costa (Nature Research, 2019)

  In the present study, patients with acute OROV fever were classified as early seroconverters (IgM/IgG positive at baseline) or late seroconverters (IgM/IgG negative at baseline) and the timeline kinetics of the production ...

• Are booster doses of yellow fever vaccine needed? 

  Vasconcelos, Pedro Fernando da Costa; Barrett, Alan D. T (Elsevier, 2019)

• Short-lived immunity after 17DD Yellow Fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children 

  Campi-Azevedo, Ana Carolina; Reis, Laise Rodrigues; Peruhype-Magalhães, Venessa; Reis, Jordana Grazziela Coelho dos; Antonelli, Lis Ribeiro; Fonseca, Cristina Toscano; Costa-Pereira, Christiane; Souza-Fagundes, Elaine Maria; Costa-Rocha, Ismael Artur da; Mambrini, Juliana Vaz de Melo; Lemos, Jandira Aparecida Campos; Ribeiro, José Geraldo Leite; Caldas, Iramaya Rodrigues; Camacho, Luiz Antônio Bastos; Maia, Maria de Lourdes de Sousa; Noronha, Tatiana Guimarães de; Lima, Sheila Maria Barbosa de; Simões, Marisol; Freire, Marcos da Silva; Martins, Reinaldo de Menezes; Homma, Akira; Tauil, Pedro Luiz; Vasconcelos, Pedro Fernando da Costa; Romano, Alessandro Pecego Martins; Domingos, Carla Magda; Teixeira-Carvalho, Andréa; Martins Filho, Olindo Assis (Frontiers Media, 2019)

  The Yellow Fever (YF) vaccination is recommended for people living in endemic areas and represents the most effective strategy to reduce the risk of infection. Previous studies have warned that booster regimens should be ...

• Risk of Zika microcephaly correlates with features of maternal antibodies 

  Robbiani, Davide F; Olsen, Priscilla C; Costa, Federico; Wang, Qiao; Oliveira, Thiago Y; Nery Jr, Nivison; Aromolaran, Adeolu; Rosário, Mateus S. do; Sacramento, Gielson A; Cruz, Jaqueline S; Khouri, Ricardo; Wunder Jr, Elsio A; Mattos, Adriana; Freitas, Bruno de Paula; Sarno, Manoel; Archanjo, Gracinda; Daltro, Dina; Carvalho, Gustavo B. S; Pimentel, Kleber; Siqueira, Isadora C. de; Almeida, João R. M. de; Henriques, Daniele Freitas; Lima, Juliana A; Vasconcelos, Pedro Fernando da Costa; Schaefer-Babajew, Dennis; Azzopardi, Stephanie A; Bozzacco, Leonia; Gazumyan, Anna; Belfort Jr, Rubens; Alcântara, Ana P; Carvalho, Gustavo; Moreira, Licia; Araujo, Katiaci; Reis, Mitermayer G; Keesler, Rebekah I; Coffey, Lark L; Tisoncik-Go, Jennifer; Gale Jr, Michael; Rajagopal, Laksmi; Waldorf, Kristina M. Adams; Dudley, Dawn M; Simmons, Heather A; Mejia, Andres; O'Connor, David H; Steinbach, Rosemary J; Haese, Nicole; Smith, Jessica; Lewis, Anne; Colgin, Lois; Roberts, Victoria; Frias, Antonio; Kelleher, Meredith; Hirsch, Alec; Streblow, Daniel N; Rice, Charles M; MacDonald, Margaret R; Almeida, Antonio R. P. de; Rompay, Koen K. A. Van; Ko, Albert I; Nussenzweig, Michel (Rockefeller University Press, 2019)

  Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response ...

• Clinical and molecular diagnosis of Chlamydophila in captive parrots in Pará State, Brazil 

  Araújo, Simone Aparecida Almeida; Pereira, Washington Luiz Assunção; Silva, Sandro Patroca da; Cardoso, Jedson Ferreira; Silva Filho, Ednaldo da; Bernal, Marcella Katheryne Marques; Mendes, Fernanda Figueiredo; Nunes, Márcio Roberto Teixeira (Universidade Estadual de Londrina, 2019)

  Parrots (Order Psittaciformes) are globally distributed birds that, together with members of the Columbiformes, represent the most susceptible animals, in regards to infection by Chlamydophila psittaci, which is an ...

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