• Serological evidence of Eastern equine encephalitis circulation in equids in Pará state, Brazil 

  Nunes, Josynélia do Socorro da Silva Sena; Casseb, Lívia Medeiros Neves; Guimarães, Ricardo José de Paula Souza e; Reis, Wilgner Duarte Magalhães; Barros, Bruno de Cássio Veloso de; Ferreira, Milene Silveira; Chiang, Jannifer Oliveira; Pinheiro, Helder Henrique Costa; Vasconcelos, Pedro Fernando da Costa; Cruz, Ana Cecília Ribeiro (Sociedade de Medicina Veterinária do Rio de Janeiro, 2021)

  Serum samples from 89 equids were analyzed (75 horses, 9 donkeys, and 5 mules) from the municipality of Viseu, Pará state, Brazil. Samples were collected in November 2014 and August 2015. The antibody prevalence against ...

• Doença de Chagas aguda no estado do Pará, Brasil: série histórica de aspectos clínicos e epidemiológico em três municípios, no período de 2007 a 2015 

  Vilhena, Andrezza Ozela de; Pereira, Waltair Maria Martins; Oliveira, Silvio Silva de; Fonseca, Paulo Fernando Lauria; Ferreira, Milene Silveira; Oliveira, Tatyellen Natasha da Costa; Adami, Marcos; Lima, Patricia Danielle Lima de (MS/SVS/Instituto Evandro Chagas, 2020)

  OBJETIVO: Analisar o perfil clínico e epidemiológico da doença de Chagas aguda nos municípios de Belém, Abaetetuba e Breves, estado do Pará, Brasil, de 2007 a 2015. MATERIAIS E MÉTODOS: Foram analisados 696 casos, a partir ...

• Perspectives on new vaccines against arboviruses using insect-specific viruses as platforms 

  Carvalho, Valéria Lima; Long, Maureen T (MDPI, 2021)

  Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are ...

• Study of arboviruses in Philander opossum, Didelphis marsupialis and Nectomys rattus captured from forest fragments in the municipality of Belem, Para, Brazil 

  Bernal, Marcella Katheryne Marques; Chiang, Jannifer Oliveira; Mendes, Fernanda Figueiredo; Andrade, Sara Letícia dos Santos; Silva, Sandy Kelly Souza Marques da; Pereira, Washington Luiz Assunção (Universidade Federal de Santa Maria, 2021)

  Arboviruses are viruses that maintain their life cycle in the wild and are transmitted to vertebrate hosts by hematophagous diptera. They are zoonotic and can establish an enzootic cycle in the urban areas; in humans, the ...

• Histopathological lesions of congenital Zika syndrome in newborn squirrel monkeys 

  Alcantara, Bianca Nascimento de; Imbeloni, Aline Amaral; Durans, Darlene de Brito Simith; Araújo, Marialva Tereza Ferreira de; Cruz, Ermelinda do Rosário Moutinho da; Carvalho, Carlos Alberto Marques de; Mendonça, Maria Helena Rodrigues de; Sousa, Jorge Rodrigues de; Moraes, Adriana Freitas; Martins Filho, Arnaldo Jorge; Lima, Maria de Lourdes Gomes; Amador Neto, Orlando Pereira; Chiang, Jannifer Oliveira; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa; Medeiros, Daniele Barbosa de Almeida (Nature Research, 2021)

  The absence of an adequate animal model for studies has limited the understanding of congenital Zika syndrome (CZS) in humans during the outbreak in America. In this study, we used squirrel monkeys (Saimiri collinsi), a ...

• Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil 

  Resende, Paola Cristina; Delatorre, Edson; Graf, Tiago; Mir, Daiana; Motta, Fernando Couto; Appolinario, Luciana Reis; Paixão, Anna Carolina Dias da; Mendonça, Ana Carolina da Fonseca; Ogrzewalska, Maria; Caetano, Braulia; Wallau, Gabriel Luz; Docena, Cássio; Santos, Mirleide Cordeiro dos; Ferreira, Jessylene de Almeida; Sousa Júnior, Edivaldo Costa; Silva, Sandro Patroca da; Fernandes, Sandra Bianchini; Vianna, Lucas Alves; Souza, Larissa da Costa; Ferro, Jean F. G; Nardy, Vanessa B; Santos, Cliomar A; Riediger, Irina; Debur, Maria do Carmo; Croda, Júlio; Oliveira, Wanderson Kleber; Abreu, André; Bello, Gonzalo; Siqueira, Marilda M (Frontiers Media, 2021)

  A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we ...

• Insect-specific viruses: an overview and their relationship to arboviruses of concern to humans and animals 

  Carvalho, Valéria Lima; Long, Maureen T (Elsevier, 2021)

  The group of Insect-specific viruses (ISVs) includes viruses apparently restricted to insects based on their inability to replicate in the vertebrates. Increasing numbers of ISVs have been discovered and characterized ...

• Individual, household and environmental factors associated with arboviruses in rural human populations, Brazil 

  Catenacci, Lilian S; Ferreira, Milene S; Fernades, Debora; Padda, Hannah; Rosa, Elizabeth Salbé Tavassos da; Deem, Sharon L; Vasconcelos, Pedro Fernando da Costa; Martins, Livia Carício (Wiley, 2021)

  Landscape change is one of the foremost drivers of the emergence of infectious diseases. Exploring demographic, household and environmental conditions under which infectious diseases occur may inform strategies to prevent ...

• Current understanding of the role of cholesterol in the life cycle of Alphaviruses 

  Sousa Jr, Ivanildo P; Carvalho, Carlos A. M; Gomes, Andre M. O (MDPI, 2021)

  Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are ...

• Prenatal disorders and congenital Zika syndrome in squirrel monkeys 

  Imbeloni, Aline Amaral; Alcantara, Bianca Nascimento de; Coutinho, Leandro Nassar; Scalercio, Sarah Raphaella Rocha de Azevedo; Carneiro, Liliane Almeida; Oliveira, Karol Guimarães; Martins Filho, Arnaldo Jorge; Durans, Darlene de Brito Simith; Silva, Wellington Bandeira da; Nunes, Bruno Tardelli Diniz; Casseb, Livia Medeiros Neves; Chiang, Jannifer Oliveira; Carvalho, Carlos Alberto Marques de; Machado, Mariana Borges; Quaresma, Juarez Antônio Simões; Medeiros, Daniele Barbosa de Almeida; Vasconcelos, Pedro Fernando da Costa (Nature Research, 2021)

  During the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this ...

• Urine qPCR diagnoses over the entire clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infections in the Brazilian Amazon 

  Ramos, Patrícia Karla Santos; Gonçalves, Lucas Pantoja; Alves, Ana Camila Oliveira; Casseb, Samir Mansour Moraes; Lima, Luciana Vieira do Rêgo; Campos, Marliane Batista; Santos, Thiago Vasconcelos dos; Silveira, Fernando Tobias (Elsevier, 2021)

  The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infections in the Brazilian Amazon has been defined using DTH/IFAT-IgG immune assays and the clinical statuses of infected individuals, revealing ...

• Role of mutational reversions and fitness restoration in Zika virus spread to the Americas 

  Liu, Jianying; Liu, Yang; Shan, Chao; Nunes, Bruno Tardelli Diniz; Yun, Ruimei; Haller, Sherry L; Rafael, Grace H; Azar, Sasha R; Andersen, Clark R; Plante, Kenneth; Vasilakis, Nikos; Shi, Pei-Yong; Weaver, Scott C (Nature Research, 2021)

  Zika virus (ZIKV) emerged from obscurity in 2013 to spread from Asia to the South Pacific and the Americas, where millions of people were infected, accompanied by severe disease including microcephaly following congenital ...

• Comparing quality of reporting between preprints and peer-reviewed articles in the biomedical literature 

  Carneiro, Clarissa F. D; Queiroz, Victor G. S; Moulin, Thiago C; Carvalho, Carlos A. M; Hass, Clarissa B; Rayêe, Danielle; Henshall, David E; Souza, Evandro A. de; Espinelli, Felippe; Boss, Flávia Z; Guercio, Gerson D; Costa, Igor R; Hajdu, Karina L; Modrák, Martin; Tan, Pedro B; Burgess, Steven J; Guerra, Sylvia de Fátima dos Santos; Bortoluzzi, Vanessa T; Amaral, Olavo B (Cold Spring Harbor Laboratory, 2020)

  Preprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is ...

• The obscurance of the greatest sylvatic yellow fever epidemic and the cooperation of the Pan American Health Organization during the COVID-19 pandemic 

  Melo, Carlos Frederico Campelo de Albuquerque e; Vasconcelos, Pedro Fernando da Costa; Alcantara, Luiz Carlos Júnior; Araujo, Wildo Navegantes de (Sociedade Brasileira de Medicina Tropical, 2020)

  Introduction: Since 2016, Brazil has been in the midst of its largest sylvatic yellow fever epidemic ever, found predominantly outsidethe Amazon region. Cases originating from Brazil have been reported in France, the ...

• Experimental yellow fever virus infection in the squirrel monkey (Saimiri spp.) I: gross anatomical and histopathological findings in organs at necropsy 

  Ferreira, Milene Silveira; Bezerra Junior, Pedro Soares; Cerqueira, Valíria Duarte; Rivero, Gabriela Riet Correa; Oliveira Junior, Carlos Alberto; Castro, Paulo Henrique Gomes; Silva, Gilmara Abreu da; Silva, Wellington Bandeira da; Imbeloni, Aline Amaral; Sousa, Jorge Rodrigues; Araújo, Ana Paula Sousa; Silva, Franko de Arruda e; Tesh, Robert B; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Instituto Oswaldo Cruz, 2020)

  BACKGROUND Non-human primates contribute to the spread of the yellow fever virus (YFV) and the establishment of transmission cycles in endemic areas. OBJECTIVE To describe the severe histopathological aspects of YFV ...

• Mitochondrial genome sequencing and phylogeny of Haemagogus albomaculatus, Haemagogus leucocelaenus, Haemagogus spegazzinii, and Haemagogus tropicalis (Diptera: Culicidae) 

  Silva, Fábio Silva da; Cruz, Ana Cecília Ribeiro; Medeiros, Daniele Barbosa de Almeida; Silva, Sandro Patroca da; Nunes, Márcio Roberto Teixeira; Martins, Lívia Carício; Chiang, Jannifer Oliveira; Lemos, Poliana da Silva; Cunha, Gabriel Muricy; Araujo, Renato Freitas de; Monteiro, Hamilton Antônio de Oliveira; Nunes Neto, Joaquim Pinto (Nature Research, 2020)

  The genus Haemagogus (Diptera: Culicidae) comprises species of great epidemiological relevance, involved in transmission cycles of the Yellow fever virus and other arboviruses in South America. So far, only Haemagogus ...

• Evaluation of immunoglobulin M-specific capture enzyme-linked immunosorbent assays and commercial tests for flaviviruses diagnosis by a National Reference Laboratory 

  Henriques, Daniele Freitas; Nunes, Juliana A. L; Anjos, Maura V; Melo, Juliana M; Rosário, Wallace O; Azevedo, Raimunda do Socorro da Silva; Chiang, Jannifer Oliveira; Martins, Livia Carício; Santos, Flavia B. dos; Casseb, Livia Medeiros Neves; Vasconcelos, Pedro Fernando da Costa; Rodrigues, Sueli Guerreiro (Elsevier, 2020)

  Zika and Dengue viruses present considerable immunological cross-reactivity, resulting in a troublesome serodiagnosis due to occurrence of false positive results. Due to Brazil’s wide variety of circulating flaviviruses ...

• Characterization of Mycobacterium tuberculosis var. africanum isolated from a patient with pulmonary tuberculosis in Brazil 

  Rabahi, Marcelo Fouad; Conceição, Emilyn Costa; Paiva, Luísa Oliveira de; Souto, Marcos Vinícius Muniz Lemes; Sisco, Maria Carolina; Waard, Jacobus de; Caldas, Paulo Cesar de Souza; Fandinho, Fatima; Ramos, Jesus Pais; Carvalho, Luciana Distasio de; Campos, Carlos Eduardo Dias; Lima, Karla Valéria Batista; Silva, Sandro Patroca da; Sharma, Abhinav; Robledo, Jaime; Paez, Uriel Alonso Hurtado; Duarte, Rafael Silva; Silva, Marlei Gomes da; Gomes, Lia Lima; Vasconcellos, Sidra Ezidio Gonçalves; Uwezeye, Cecile; Jong, Bouke C. de; Junqueira-Kipnis, Ana Paula; Suffys, Philip Noel (Elsevier, 2020)

  Human tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC), including Mycobacterium tuberculosis var. tuberculosis (MTB) and Mycobacterium tuberculosis var. africanum (MAF). While MTB is ...

• The innate immune response in Zika virus infection 

  Sousa, Jorge Rodrigues de; Azevedo, Raimunda do Socorro da Silva; Quaresma, Juarez Antônio Simões; Vasconcelos, Pedro Fernando da Costa (Wiley, 2020)

  Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa, from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive‐sense, single‐stranded RNA virus, which encodes ...

• Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon 

  Oliveira, Consuelo Silva de; Matos, Haroldo José de; Ramos, Francisco Lúzio de Paula; Pinto, Ana Yecê das Neves; Graim, Priscila Nathyelly dos S; Guimarães, Vivianne de Paula R; Gomes, Luna Thaís S; Serra, Emilene M. F; Cruz, Ana Cecília Ribeiro; Leal, Alessandra; Henriques, Daniele Freitas; Lima, Juliana A; Anjos, Maura V; Pinto, Eliana Vieira Pinto da; Souza, Alana W. de; Vasconcelos, Pedro Fernando da Costa (Pan American Health Organization, 2020)

  Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected ...

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