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dc.contributor.authorMenezes, Rubens Alex de Oliveira-
dc.contributor.authorGomes, Margarete do Socorro Mendonça-
dc.contributor.authorMendes, Ana Paula Martins-
dc.contributor.authorCouto, Álvaro Augusto Ribeiro D’Almeida-
dc.contributor.authorNacher, Mathieu-
dc.contributor.authorPimenta, Tamirys Simão-
dc.contributor.authorSousa, Aline Collares Pinheiro de-
dc.contributor.authorBaptista, Andrea Regina de Souza-
dc.contributor.authorJesus, Maria Izabel de-
dc.contributor.authorEnk, Martin Johannes-
dc.contributor.authorCunha, Maristela Gomes-
dc.contributor.authorMachado, Ricardo Luiz Dantas-
dc.date.accessioned2018-02-27T19:10:34Z-
dc.date.available2018-02-27T19:10:34Z-
dc.date.issued2018-
dc.identifier.citationMENEZES, Rubens Alex de Oliveira et al. Enteroparasite and vivax malaria co-infection on the Brazil-French Guiana border: epidemiological, haematological and immunological aspects. PLoS ONE, v. 13, n. 1, e0189958, p. 1-20, Jan. 2018.pt_BR
dc.identifier.issn1932-6203-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3052-
dc.description.abstractMalaria-enteroparasitic co-infections are known for their endemicity. Although they are prevalent, little is known about their epidemiology and effect on the immune response. This study evaluated the effect of enteroparasite co-infections with malaria caused by Plasmodium vivax in a border area between Brazil and French Guiana. The cross sectional study took place in Oiapoque, a municipality of Amapá, on the Amazon border. Malaria was diagnosed using thick blood smears, haemoglobin dosage by an automated method and coproparasitology by the Hoffman and Faust methods. The anti-PvMSP-119 IgG antibodies in the plasma were evaluated using ELISA and Th1 (IFN-γ, TNF-α and IL-2), and Th2 (IL-4, IL-5 and IL-10) cytokine counts were performed by flow cytometry. The participants were grouped into those that were monoinfected with vivax malaria (M), vivax malaria-enteroparasite co-infected (CI), monoinfected with enteroparasite (E) and endemic controls (EC), who were negative for both diseases. 441 individuals were included and grouped according to their infection status: [M 6.9% (30/441)], [Cl 26.5% (117/441)], [E 32.4% (143/441)] and [EC 34.2% (151/441)]. Males prevailed among the (M) 77% (23/30) and (CI) 60% (70/117) groups. There was a difference in haemoglobin levels among the different groups under study for [EC-E], [EC-Cl], [E-M] and [Cl-M], with (p < 0.01). Anaemia was expressed as a percentage between individuals [CI-EC (p < 0.05)]. In terms of parasitaemia, there were differences for the groups [CI-M (p < 0.05)]. Anti-PvMSP-119 antibodies were detected in 51.2% (226/441) of the population. The level of cytokines evaluation revealed a large variation in TNF-α and IL-10 concentrations in the co-infected group. In this study we did not observe any influence of coinfection on the acquisition of IgG antibodies against PvMSP119, as well as on the profile of the cytokines that characterize the Th1 and Th2 patterns. However, co-infection increased TNF-α and IL-10 levels.pt_BR
dc.language.isoengpt_BR
dc.publisherPublic Library of Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.titleEnteroparasite and vivax malaria co-infection on the Brazil-French Guiana border: epidemiological, haematological and immunological aspectspt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryMalária Vivax / sanguept_BR
dc.subject.decsPrimaryMalária Vivax / complicaçõespt_BR
dc.subject.decsPrimaryMalária Vivax / epidemiologiapt_BR
dc.subject.decsPrimaryDoenças Parasitárias / sanguept_BR
dc.subject.decsPrimaryDoenças Parasitárias / complicaçõespt_BR
dc.subject.decsPrimaryDoenças Parasitárias / epidemiologiapt_BR
dc.subject.decsPrimaryProteínas de Protozoários / imunologiapt_BR
dc.subject.decsPrimaryEnteropatias Parasitárias / epidemiologiapt_BR
dc.subject.decsPrimaryEstudos Transversais / métodospt_BR
dc.subject.decsPrimaryCitocinas / sanguept_BR
dc.subject.decsPrimaryCoinfecção / parasitologiapt_BR
dc.subject.decsPrimaryEnsaio de Imunoadsorção Enzimática / métodospt_BR
dc.subject.decsPrimaryCitometria de Fluxo / métodospt_BR
dc.subject.decsPrimaryImunoglobulina G / imunologiapt_BR
dc.subject.decsPrimaryFezes / parasitologiapt_BR
dc.subject.decsPrimaryHelmintíase / parasitologiapt_BR
dc.subject.decsPrimaryBrasil / epidemiologiapt_BR
dc.subject.decsPrimaryGuiana Francesa / epidemiologiapt_BR
dc.creator.affilliationFederal University of Para. Postgraduate Program in the Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Amapa. Laboratory of morphofunctional and parasitic studies with impact on health. Macapá, AP, Brazil.pt_BR
dc.creator.affilliationAmapá State Secretary of Health. Amapá Central Laboratory. Macapá, AP, Brazil.pt_BR
dc.creator.affilliationFederal University of Amapá - Oiapoque Binational Campus. Oiapoque, AP, Brazil.pt_BR
dc.creator.affilliationAmapá State Secretary of Health. Amapá Central Laboratory. Macapá, AP, Brazil.pt_BR
dc.creator.affilliationCentre Hospitalier de Cayenne. Centre d’Investigation Clinique. Cayenne, French Guiana.pt_BR
dc.creator.affilliationFederal University of Para. Postgraduate Program in Neuroscience and Cell Biology. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFluminense Federal University. Niterói, RJ, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationFederal University of Para. Postgraduate Program in the Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Para. Laboratory of Microbiology and Immunology. Belém, PA, Brazil.pt_BR
dc.creator.affilliationFederal University of Para. Postgraduate Program in the Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. / Fluminense Federal University, Nitero´i, Rio de Janeiro State, Brazil,pt_BR
dc.identifier.doi10.1371/journal.pone.0189958-


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