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An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

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2018
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An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction.pdf (3.004xmlui.dri2xhtml.METS-1.0.size-megabytes)
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http://patua.iec.gov.br//handle/iec/3060
xmlui.dri2xhtml.METS-1.0.item-author
Xia, Hongjie
Luo, Huanle
Shan, Chao
Muruato, Antonio E
Nunes, Bruno Tardelli Diniz
Medeiros, Daniele Barbosa de Almeida
Zou, Jing
Xie, Xuping
Giraldo, Maria Isabel
Vasconcelos, Pedro Fernando da Costa
Weaver, Scott C
Wang, Tian
Rajsbaum, Ricardo
Shi, Pei-Yong
xmlui.dri2xhtml.METS-1.0.item-abstract
Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection. Here we report that the same mutation confers NS1 to inhibit interferon-β induction. This mutation enables NS1 binding to TBK1 and reduces TBK1 phosphorylation. Engineering the mutation into a pre-epidemic ZIKV strain debilitates the virus for interferon-β induction; reversing the mutation in an epidemic ZIKV strain invigorates the virus for interferon-β induction; these mutational effects are lost in IRF3-knockout cells. Additionally, ZIKV NS2A, NS2B, NS4A, NS4B, and NS5 can also suppress interferon-β production through targeting distinct components of the RIG-I pathway; however, for these proteins, no antagonistic difference is observed among various ZIKV strains. Our results support the mechanism that ZIKV has accumulated mutation(s) that increases the ability to evade immune response and potentiates infection and epidemics.
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XIA, Hongjie et al. An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction. Nature Communications, v. 9, n. 1, p. 1-13, Jan. 2018.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Zika virus / patogenicidade
Infecção pelo Zika virus / diagnóstico
Interações Hospedeiro-Parasita / imunologia
Mutagênese / imunologia
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  • SAARB - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br