Clinical severity and rotavirus vaccination among children hospitalized for ccute gastroenteritis in Belém, Northern Brazil
Justino, Maria Cleonice Aguiar
Mascarenhas, Joana D'Arc Pereira
Guerra, Sylvia de Fátima dos Santos
Linhares, Alexandre da Costa
In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (RotarixTM) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n ¼ 252), partially vaccinated (n ¼ 156) and fully vaccinated (n ¼ 615) children. Very severe gastroenteritis (scored 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p ¼ 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.
xmlui.dri2xhtml.METS-1.0.item-citationJUSTINO, Maria Cleonice Aguiar et al. Clinical severity and rotavirus vaccination among children hospitalized for acute gastroenteritis in Belém, Northern Brazil. Journal of Tropical Pediatrics, v. 62, n. 4, p. 276–281, Aug. 2016.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryGastroenterite / prevenção & controle
Gastroenterite / virologia
Infecções por Rotavirus / prevenção & controle
Rotavirus / imunologia
Vacinas contra Rotavirus / uso terapêutico
Índice de Gravidade de Doença
Resultado do Tratamento
Ensaio de Imunoadsorção Enzimática / métodos