Seizures as a complication of Congenital Zika Syndrome in early infancy.
Oliveira Filho, Jamary
Nery Jr, Nivison
Henriques, Daniele Freitas
Ko, Albert I
Abstract. Zika virus transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 ± 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures (P < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1–23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment.
xmlui.dri2xhtml.METS-1.0.item-citationOLIVEIRA FILHO, Jamary et al. Seizures as a complication of Congenital Zika Syndrome in early infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860-1862, June 2018.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryZika virus / patogenicidade
Microcefalia / complicações
Anormalidades Congênitas / embriologia
Infecção pelo Zika virus / embriologia