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dc.contributor.authorNunes, Márcio Roberto Teixeira-
dc.contributor.authorSouza, William Marciel de-
dc.contributor.authorAcrani, Gustavo Olszanski-
dc.contributor.authorCardoso, Jedson Ferreira-
dc.contributor.authorSilva, Sandro Patroca da-
dc.contributor.authorBadra, Soraya Jabur-
dc.contributor.authorFigueiredo, Luiz Tadeu Moraes-
dc.contributor.authorVasconcelos, Pedro Fernando da Costa-
dc.date.accessioned2018-07-09T12:20:43Z-
dc.date.available2018-07-09T12:20:43Z-
dc.date.issued2018-
dc.identifier.citationNUNES, Márcio Roberto Teixeira et al. Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas. PLoS ONE, v. 13, n. 5, e0197294, May 2018.pt_BR
dc.identifier.issn1932-6203-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3191-
dc.description.abstractGroup C serogroup includes members of the Orthobunyavirus genus (family Peribunyaviridae) and comprises 15 arboviruses that can be associated with febrile illness in humans. Although previous studies described the genome characterization of Group C orthobunyavirus, there is a gap in genomic information about the other viruses in this group. Therefore, in this study, complete genomes of members of Group C serogroup were sequenced or resequenced and used for genetic characterization, as well as to understand their phylogenetic and evolutionary aspects. Thus, our study reported the genomes of three new members in Group C virus (Apeu strain BeAn848, Itaqui strain BeAn12797 and Nepuyo strain BeAn10709), as well as re-sequencing of original strains of five members: Caraparu (strain BeAn3994), Madrid (strain BT4075), Murucutu (strain BeAn974), Oriboca (strain BeAn17), and Marituba (strain BeAn15). These viruses presented a typical genomic organization related to members of the Orthobunyavirus genus. Interestingly, all viruses of this serogroup showed an open reading frame (ORF) that encodes the putative nonstructural NSs protein that precedes the nucleoprotein ORF, an unprecedented fact in Group C virus. Also, we confirmed the presence of natural reassortment events. This study expands the genomic information of Group C viruses, as well as revalidates the genomic organization of viruses that were previously reported.pt_BR
dc.description.sponsorshipWork in Brazil was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico grants 302987/2008-8, 302584/2015-3 (MRTN). WMS is supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Scholarships N°. 12/24150-9). PFCV was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico grants, 457664/2013-4 and 303999/2016-0.pt_BR
dc.language.isoengpt_BR
dc.publisherPublic Library of Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.titleRevalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americaspt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryOrthobunyavirus / genéticapt_BR
dc.subject.decsPrimaryGenoma Viral / genéticapt_BR
dc.subject.decsPrimaryAnálise de Sequência de DNApt_BR
dc.subject.decsPrimaryVírus de RNA / isolamento & purificaçãopt_BR
dc.subject.decsPrimaryNucleotídeos / genéticapt_BR
dc.subject.decsPrimaryMapeamento de Nucleotídeos / métodospt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of São Paulo. School of Medicine of Ribeirão Preto. Virology Research Center. Ribeirão Preto, SP, Brazil.pt_BR
dc.creator.affilliationUniversidade Federal da Fronteira Sul - Campus Passo Fundo. Rio Grande do Sul, RS, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasilpt_BR
dc.creator.affilliationUniversity of São Paulo. School of Medicine of Ribeirão Preto. Virology Research Center. Ribeirão Preto, SP, Brazil.pt_BR
dc.creator.affilliationUniversity of São Paulo. School of Medicine of Ribeirão Preto. Virology Research Center. Ribeirão Preto, SP, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.pt_BR
dc.identifier.doi10.1371/journal.pone.0197294-


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