Survey of parvovirus B19 infection in a cohort of pregnant women in Belém, Brazil
Freitas, Ronaldo Barros de
Gusmão, Silvio Romero Buarque de
Durigon, Edison Luiz
Linhares, Alexandre da Costa
In our study, 300 pregnant women were screened for the presence of human parvovirus B19 IgG and IgM antibodies by an enzyme-linked immunosorbent assay (ELISA). Overall, 253 (84.3%) were found to be IgG-positive and IgM-negative (IgG+gM ), 42 (14%) had neither IgG nor IgM antibodies (IgG /IgM ) and 5 (1.7%) were both IgM- and IgG-positive (IgG+/IgM+). Maternal serology was performed routinely for cytomegalovirus, rubella, toxoplasmosis and syphilis. All IgG /IgM and IgG+/IgM+ women were followed up till the time of delivery, venous blood sample being taken monthly from each one; one IgG /IgM mother seroconverted to IgG+/IgM and B19 DNA was detected by nested polymerase chain reaction technique (PCR) in her serum. All babies born to IgG+/IgM+ mothers (and from that who seroconverted) were IgG+IgM , no B19 DNA could be detected in their sera and no adverse effects were documented either by ultrasonographic examination or the detection of maternal serum alpha-fetoprotein. While 5 of these mothers delivered normal children at term, one gave birth to a premature (low-weight) baby who developed severe anemia and had convulsions; this mother was found to have toxoplasma-specific IgM. As based on serial testing of sera, it is notable that B19 IgM may last up to six months. Our data indicates a low incidence rate of B19 infection in pregnancy in our region, at least during interepidemic periods. In addition, it suggests that recent B19 infection represents a low risk for the development of adverse fetal outcomes.
xmlui.dri2xhtml.METS-1.0.item-citationFREITAS, Ronaldo Barros de et al. Survey of parvovirus B19 infection in a cohort of pregnant women in Belém, Brazil. Brazilian Journal of Infectious Diseases, v. 3, n. 1, p. 6-14, 1999.
xmlui.dri2xhtml.METS-1.0.item-decsPrimaryParvovirus B19 Humano