Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta-analysis
Linhares, Alexandre da Costa
Stupka, Juan A
Bardach, Ariel E
Aruj, Patricia K
Rodriguez, Jefferson A. Buendía
Lanzieri, Tatiana M
The efficacy of licensed rotavirus vaccines has only been shown against certain rotavirus group A (RV-A) types. It is critical to understand the burden of rotavirus gastroenteritis (RVGE) and its prevalent types to assess the potential impact of these vaccines in Latin America and the Caribbean (LA&C). We performed a systematic review and meta-analyses of all the available evidence reported from 1990 to 2009 on the burden of rotavirus disease and strains circulating in LA&C. Eligible studies--185 country-level reports, 174 951 faecal samples--were selected from MEDLINE, Cochrane Library, EMBASE, LILACS, regional Ministries of Health, PAHO, regional proceedings, doctoral theses, reference lists of included studies and consulting experts. Arc-sine transformations and DerSimonian-Laird random-effects model were used for meta-analyses. The proportion of gastroenteritis cases due to rotavirus was 24.3% (95%CI 22.3-26.4) and the incidence of RVGE was 170 per 1000 children-years (95%CI 130-210). We estimated a global annual mortality for 22 countries of 88.2 (95%CI 79.3-97.1) deaths per 100 000 under 5 years (47 000 deaths).The most common G type detected was G1 (34.2%), followed by G9 (14.6%), and G2 (14.4%). The most common P types detected were P (56.2%), P (22.1%) and P 5.4%, and the most prevalent P-G type associations were PG1 17.9%, PG2 9.1% and PG9 8.8%. In the last 10 years, G9 circulation increased remarkably and G5 almost disappeared. More recently, G12 appeared and PG2 re-emerged. To our knowledge, this is the first meta-analysis of rotavirus infection and burden of disease in LA&C.
xmlui.dri2xhtml.METS-1.0.item-citationLINHARES, Alexandre da Costa et al. Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta-analysis. Reviews in Medical Virology, v. 21, n. 2, p. 89-109, 2001.
Vacinas contra Rotavirus / análise
Metanálise como Assunto
Bases de Dados Bibliográficas / utilização