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Rotavirus gastroenteritis in Latin America: a hospital-based study in children under 3 years of age

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2012
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Rotavirus gastroenteritis in Latin America: a hospital-based study in children under 3 years of age.pdf (263.5Kb)
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URI
http://patua.iec.gov.br//handle/iec/3267
Autor
Linhares, Alexandre da Costa
Macias-Parra, Mercedes
Sáez-Llorens, Xavier
Vergara, Rodrigo
Jimenez, Elias
Velázquez, F. Raul
Cervantes, Yolanda
Abate, Héctor José
Rivera, Luis
Ruttimann, Ricardo
Rivera-Medina, Doris Maribel
Salinas, Belén
Ortega-Barria, Eduardo
Rubio, Pilar
Breuer, Thomas B
Resumo
Rotavirus is the leading cause of severe diarrheal disease and dehydration in infants in both developed and developing countries. Vaccines have recently been developed, but detailed epidemiological information, which is needed for decisions about how and where to introduce vaccination, was lacking for many Latin American countries. The primary objective of this study was to measure the incidence and disease burden of rotavirus in young children presenting to Latin American hospitals with gastroenteritis. In addition it allowed to setting up the methodology to further conduct a large phase III trial with a rotavirus vaccine in the region. This was a prospective, multi-center surveillance study of gastroenteritis in children <3 years old presenting to hospitals in 11 Latin American countries. Questionnaires and stool samples were collected from 6521 of 8031 enrolled cases (73% inpatients). Among these, 3122 (49%) were rotavirus positive. Of the rotavirus-positive cases, 12% were <6 months, 48% <1 year and 87% <2 years old; 23% received antibiotics before diagnosis. Median hospital stay was 2 days, 78% received intravenous rehydration. Overall strain distribution was G1 (59%), G2 (1%), G3 (12%), G4 (20%), G9 (6%), G12 (1%), untypable (7%) with large local variations. The direct economic impact on families was considerable: 48% of caregivers lost time from paid work and 69% of families were financially affected by their child's illness. This study confirms the high disease burden of rotavirus gastroenteritis among children in Latin America, which might be reduced by the use of effective vaccines.
Referência
LINHARES, Alexandre da Costa et al. Rotavirus gastroenteritis in Latin America: a hospital-based study in children under 3 years of age. Trials in Vaccinology, v. 1, p. 36-41, 2012.
DeCs
Gastroenterite
Infecções por Rotavirus
Vacinas contra Rotavirus
Diarreia
Rotavírus
Direito Autoral
Acesso Aberto
Coleções
  • SAVIR - Artigos Científicos

Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br