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dc.contributor.authorXie, Xuping-
dc.contributor.authorKum, Dieudonné B-
dc.contributor.authorXia, Hongjie-
dc.contributor.authorLuo, Huanle-
dc.contributor.authorShan, Chao-
dc.contributor.authorZou, Jing-
dc.contributor.authorMuruato, Antonio E-
dc.contributor.authorMedeiros, Daniele Barbosa de Almeida-
dc.contributor.authorNunes, Bruno Tardelli Diniz-
dc.contributor.authorDallmeier, Kai-
dc.contributor.authorRossi, Shannan L-
dc.contributor.authorWeaver, Scott C-
dc.contributor.authorNeyts, Johan-
dc.contributor.authorWang, Tian-
dc.contributor.authorVasconcelos, Pedro Fernando da Costa-
dc.contributor.authorShi, Pei-Yong-
dc.date.accessioned2018-10-25T13:23:59Z-
dc.date.available2018-10-25T13:23:59Z-
dc.date.issued2018-
dc.identifier.citationXIE, Xuping et al. A single-dose live-attenuated Zika Virus vaccine with controlled infection rounds that protects against vertical transmission. Cell Host and Microbe, v. 24, n. 4, p. 487-499, Oct. 2018.pt_BR
dc.identifier.issn1934-6069-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3517
dc.description.abstractZika virus (ZIKV) infection of the mother during pregnancy causes devastating Zika congenital syndrome in the offspring. A ZIKV vaccine with optimal safety and immunogenicity for use in pregnant women is critically needed. Toward this goal, we have developed a single-dose live-attenuated vaccine candidate that infects cells with controlled, limited infection rounds. The vaccine contains a 9-amino-acid deletion in the viral capsid protein and replicates to titers of > 10 6 focus-forming units (FFU)/mL in cells expressing the full-length capsid protein. Immunization of A129 mice with one dose (10 5 FFU) did not produce viremia, but elicited protective immunity that completely prevented viremia, morbidity, and mortality after challenge with an epidemic ZIKV strain (10 6 PFU). A single-dose vaccination also fully prevented infection of pregnant mice and maternal-to-fetal transmission. Intracranial injection of the vaccine (10 4 FFU) to 1-day-old mice did not cause any disease or death, underscoring the safety of this vaccine candidate.pt_BR
dc.description.sponsorshipThe P.-Y.S. lab was supported by a Kleberg Foundation Award and NIH grant AI127744. This research was also partially supported by NIH grant AI120942 to S.C.W. and by Cooperative Agreement Number U01CK000512 to S.C.W., funded by the CDCpt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleA single-dose live-attenuated Zika Virus vaccine with controlled infection rounds that protects against vertical transmissionpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryVacinas / imunologiapt_BR
dc.subject.decsPrimaryZika virus / patogenicidadept_BR
dc.subject.decsPrimaryVacinas / antagonistas & inibidorespt_BR
dc.subject.decsPrimaryInfecção pelo Zika viruspt_BR
dc.subject.decsPrimaryProteínas do Capsídeopt_BR
dc.subject.decsPrimaryEnsaio Clínicopt_BR
dc.subject.decsPrimaryEstudos de Validaçãoen_US
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Virology and Chemoth. KU Leuven. Leuven, Belgium.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Microbiology & Immunology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Virology and Chemoth. KU Leuven. Leuven, Belgium.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Institute for Human Infections & Immunity. Galveston, TX, USA / University of Texas Medical Branch. Department of Pathology and Center for Biodefense & Emerging Infectious Diseases. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Institute for Human Infections & Immunity. Galveston, TX, USA / University of Texas Medical Branch. Institute for Translational Sciences. Galveston, TX, USA / University of Texas Medical Branch. Department of Microbiology & Immunology. Galveston, TX, USA / University of Texas Medical Branch. Department of Pathology and Center for Biodefense & Emerging Infectious Diseases. Galveston, TX, USA / University of Texas Medical Branch. Sealy Institute for Vaccine Sciences. Galveston, TX, USA.pt_BR
dc.creator.affilliationUniversity of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Virology and Chemoth. KU Leuven. Leuven, Belgium.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Microbiology & Immunology. Galveston, TX, USA / University of Texas Medical Branch. Department of Pathology and Center for Biodefense & Emerging Infectious Diseases. Galveston, TX, USA / University of Texas Medical Branch. Sealy Institute for Vaccine Sciences. Galveston, TX, USA.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Pará State University. Department of Pathology. Belém, PA, Brazil.pt_BR
dc.creator.affilliationUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA / University of Texas Medical Branch. Sealy Institute for Vaccine Sciences. Galveston, TX, USA / University of Texas Medical Branch. Sealy Center for Structural Biology & Molecular Biophysics. Galveston, TX, USA / University of Texas Medical Branch. Department of Pharmacology & Toxicology. Galveston, TX, USA.pt_BR
dc.identifier.doi10.1016/j.chom.2018.09.008-


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