Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika Virus

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2018xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/3519xmlui.dri2xhtml.METS-1.0.item-author
Sousa, Jorge R. de
Azevedo, Raimunda do Socorro da Silva
Martins Filho, Arnaldo Jorge
Araújo, Marialva T. F
Moutinho, Ermelinda R. C
Vasconcelos, Barbara C. Baldez
Cruz, Ana Cecília Ribeiro
Oliveira, Consuelo Silva de
Martins, Lívia Carício
Vasconcelos, Beatriz H. Baldez
Casseb, Livia Medeiros Neves
Chiang, Jannifer Oliveira
Quaresma, Juarez Antônio Simões
Vasconcelos, Pedro Fernando da Costa
xmlui.dri2xhtml.METS-1.0.item-abstract
Zika virus (ZIKV) is a single-stranded positive-sense RNA flavivirus that possesses a genome approximately 10.7 Kb in length. Although pro-inflammatory and anti-inflammatory cytokines and apoptotic markers belonging to the extrinsic and intrinsic pathways are suggested to be involved in fatal cases of ZIKV-induced microcephaly, their exact roles and associations are unclear. To address this, brain tissue samples were collected from 10 individuals, five of whom were diagnosed as ZIKV positive with microcephaly and a further five were flavivirus-negative controls that died because of other causes. Examination of material from the fatal cases of microcephaly revealed lesions in the cerebral cortex, edema, vascular proliferation, neuronal necrosis, gliosis, neuronophagy, calcifications, apoptosis, and neuron loss. The expression of various apoptosis markers in the neural parenchyma, including FasL, FAS, BAX, BCL2, and caspase 3 differed between ZIKV-positive cases and controls. Further investigation of type 1 and 2 helper T-cell cytokines confirmed a greater anti-inflammatory response in fatal ZIKV-associated microcephaly cases. Finally, an analysis of the linear correlation between tumor necrosis factor-α, IL-1β, IL-4, IL-10, transforming growth factor-β, and IL-33 expression and various apoptotic markers suggested that the immune response may be associated with the apoptotic phenomenon observed in ZIKV-induced microcephaly.
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SOUSA, Jorge R. de et al. Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika Virus. The American Journal of Pathology, v. 188, n. 11, p. 2644-2652, Nov. 2018.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Zika virus / patogenicidadeInfecção pelo Zika virus / patologia
Microcefalia / mortalidade
Infecções por Flavivirus
Apoptose / genética
Córtex Cerebral / lesões