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In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases

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2018
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In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases.pdf (538.1xmlui.dri2xhtml.METS-1.0.size-kilobytes)
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http://patua.iec.gov.br//handle/iec/3521
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Sousa, Jorge Rodrigues de
Azevedo, Raimunda do Socorro da Silva
Martins Filho, Arnaldo Jorge
Araújo, Marialva Tereza Ferreira de
Cruz, Ermelinda do Rosário Moutinho
Vasconcelos, Barbara Cristina Baldez
Cruz, Ana Cecília Ribeiro
Oliveira, Consuelo Silva de
Martins, Livia Carício
Vasconcelos, Beatriz Helena Baldez
Casseb, Livia Medeiros Neves
Chiang, Jannifer Oliveira
Quaresma, Juarez Antonio Simões
Vasconcelos, Pedro Fernando da Costa
xmlui.dri2xhtml.METS-1.0.item-abstract
Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that induce inflammation and pyroptosis, are predicted to contribute to the immune response to this flavivirus. Accordingly, in this study, the in situ inflammasome response was evaluated in fatal cases of ZIKV-linked microcephaly. Brain tissue samples were collected from eight babies, including four ZIKV-positive microcephalic neonates who died after birth and four flavivirus-negative neonatal controls who died of other causes and whose central nervous system (CNS) architecture was preserved. In the ZIKV-positive newborn/stillbirth babies, the major histopathological alterations included atrophy of the cortical layer, a predominance of mononuclear cell infiltration in the Virchow-Robin space, neuronal necrosis, vacuolization and neuronal degeneration, neuronophagy, and gliosis. An immunohistochemical analysis of tissues in the neural parenchyma showed significantly higher expression of the receptors NLRP1, NLRP3, and AIM2, cytokines IL-1β, IL-18, and IL-33, and enzymes caspase 1, iNOS, and arginase 1 in ZIKV-positive microcephaly cases than in flavivirus-negative controls. These results suggest that inflammasome activation can aggravate the neuroinflammatory response and consequently increase CNS damage in neonates with fetal neural ZIKV infection and microcephaly.
xmlui.dri2xhtml.METS-1.0.item-citation
SOUSA, Jorge Rodrigues de et al. In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases. Cytokine, v. 111, p. 255-264, Nov. 2018.
xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Zika virus / patogenicidade
Infecção pelo Zika virus / patologia
Microcefalia / mortalidade
Infecções por Flavivirus
Sistema Nervoso Central / anormalidades
Complexos Multiproteicos
Inflamassomos / genética
Piroptose / genética
Apoptose / genética
Córtex Cerebral / lesões
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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br
 

 

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Instituto Evandro Chagas - SVS - MS - 2007-2018 Rodovia BR316 km 7 sn - Levilandia - 67030-000 - Ananindeua - Para - Brasil.
Licença Creative CommonsEste trabalho está licenciado com uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional
Tel: (55 91) 3214-2191
Email: biblioteca@iec.gov.br / clariceneta@iec.gov.br