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dc.contributor.authorSoares, Irene S-
dc.contributor.authorOliveira, Salma Gomes-
dc.contributor.authorSouza, José Maria de-
dc.contributor.authorRodrigues, Mauricio M-
dc.date.accessioned2019-01-22T17:45:22Z-
dc.date.available2019-01-22T17:45:22Z-
dc.date.issued1999-
dc.identifier.citationSOARES, Irene S. et al. Antibody response to the N and C-terminal regions of the Plasmodium vivax merozoite surface Protein 1 in individuals living in an area of exclusive transmission of P. vivax malaria in the north of Brazil. Acta Tropica, v. 72, p. 13-24, 1999.pt_BR
dc.identifier.issn0001-706x-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3570-
dc.description.abstractRecently, we found that a recombinant protein based on the 19 kDa C-terminal region of the Plasmodium 6i6ax Merozoite Surface Protein 1 (PvMSP119) was recognized by a large proportion of individuals naturally infected. The present study was designed to determine the prevalence of antibody to PvMSP119 in individuals from the village of Cotijuba, northern Brazil, where only P. 6i6ax transmission occurs. Immuno-epidemiological studies on the prevalence of antibody to the C-terminus of PvMSP1 are of particular importance as this region of MSP1 is being intensively studied as a prime candidate for development of a vaccine against malaria. We evaluated the antibody response to PvMSP119, and compared it to the N-terminal region of PvMSP1 and to blood stage antigens. The total frequencies of individuals with IgG to blood stages, PvMSP119 or the N-terminal region of PvMSP1 were 76.6, 42.3 and 29.8%, respectively. The frequency of responders to PvMSP119 did not increase with age. However, the frequency of responders to this recombinant protein was significantly higher (77.4%) in individuals with a recent (B6 months) history of malaria, when compared to subjects whose last malaria attack occurred more than 6 months before (43.9%), or to individuals without a past history of symptomatic malaria (6.25%). These results confirm earlier studies by demonstrating that the PvMSP119 is highly immunogenic in individuals recently exposed to P. 6i6ax malaria.pt_BR
dc.description.sponsorshipThis work was supported by grants from FAPESP, PADCT, CNPq and PRONEX; I.S.S is a recipient of a fellowships from CAPES.pt_BR
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAntibody response to the N and C-terminal regions of the Plasmodium vivax merozoite surface Protein 1 in individuals living in an area of exclusive transmission of P. vivax malaria in the north of Brazilpt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryMalária Vivax / transmissãopt_BR
dc.subject.decsPrimaryPlasmodium vivax / imunologiapt_BR
dc.creator.affilliationUniversidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Patologia. Belém, PA, Brasil / Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationMinistério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.pt_BR
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brazil.pt_BR


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