A novel hepacivirus in wild rodents from South America
Autor
Souza, William Marciel de
Fumagalli, Marcílio Jorge
Santos Jr, Gilberto Sabino
Maia, Felipe Gonçalves Motta
Modha, Sejal
Nunes, Márcio Roberto Teixeira
Murcia, Pablo Ramiro
Figueiredo, Luiz Tadeu Moraes
Resumo
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the
family Flaviviridae. Several hepaciviruses have been identified in different mammals, including
multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus
has been identified in the South American continent. Here, we describe an unknown hepacivirus
discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes,
Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel
hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the
first identification of hepavivirus in sigmondonine rodents and in rodents from South America.
In sum, our results expand the host range, viral diversity, and geographical distribution of the
Hepacivirus genus.
Referência
SOUZA, William Marciel de et al. A novel hepacivirus in wild rodents from South America. Viruses. v. 11, n. 3, e297, p. 1-7, Mar. 2019.DeCs
Hepacivirus / isolamento & purificaçãoHepatite C / patologia
Flaviviridae / patogenicidade
Arvicolinae / virologia
Camundongos
Doenças dos Roedores / virologia