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dc.contributor.authorSouza, William Marciel de-
dc.contributor.authorFumagalli, Marcílio Jorge-
dc.contributor.authorSantos Jr, Gilberto Sabino-
dc.contributor.authorMaia, Felipe Gonçalves Motta-
dc.contributor.authorModha, Sejal-
dc.contributor.authorNunes, Márcio Roberto Teixeira-
dc.contributor.authorMurcia, Pablo Ramiro-
dc.contributor.authorFigueiredo, Luiz Tadeu Moraes-
dc.date.accessioned2019-04-09T16:10:03Z-
dc.date.available2019-04-09T16:10:03Z-
dc.date.issued2019-
dc.identifier.citationSOUZA, William Marciel de et al. A novel hepacivirus in wild rodents from South America. Viruses. v. 11, n. 3, e297, p. 1-7, Mar. 2019.pt_BR
dc.identifier.issn1999-4915-
dc.identifier.urihttp://patua.iec.gov.br//handle/iec/3633-
dc.description.abstractThe Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.pt_BR
dc.description.sponsorshipThis research was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant number No. 13/14929-1, and Scholarships No. 12/24150-9; 15/05778-5; 17/13981-0; 16/01414-1; 08/06411-4; 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9).pt_BR
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleA novel hepacivirus in wild rodents from South Americapt_BR
dc.typeArtigopt_BR
dc.subject.decsPrimaryHepacivirus / isolamento & purificaçãopt_BR
dc.subject.decsPrimaryHepatite C / patologiapt_BR
dc.subject.decsPrimaryFlaviviridae / patogenicidadept_BR
dc.subject.decsPrimaryArvicolinae / virologiapt_BR
dc.subject.decsPrimaryCamundongospt_BR
dc.subject.decsPrimaryDoenças dos Roedores / virologiapt_BR
dc.creator.affilliationUniversity of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil / MRC-University of Glasgow Centre for Virus Research. Glasgow, UK / University of Campinas. Institute of Biology. Department of Genetics, Evolution and Bioagents. Campinas, SP, Brazil.pt_BR
dc.creator.affilliationUniversity of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.pt_BR
dc.creator.affilliationUniversity of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazilpt_BR
dc.creator.affilliationUniversity of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil / University of São Paulo. Institute of Biomedical Sciences. São Paulo, SP, Brazil.pt_BR
dc.creator.affilliationMRC-University of Glasgow Centre for Virus Research. Glasgow, UK.pt_BR
dc.creator.affilliationMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Centro de Inovações Tecnológicas.Ananindeua, PA, Brasil.pt_BR
dc.creator.affilliationMRC-University of Glasgow Centre for Virus Research. Glasgow, UK.pt_BR
dc.creator.affilliationUniversity of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.pt_BR
dc.identifier.doi10.3390/v11030297-


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