O Centro de Inovações Tecnológicas (CIT) do Instituto Evandro Chagas foi idealizado em Novembro de 2009 e atualmente é constituído pelos Laboratórios de Genômica, Bioinformática, Proteômica, Diagnóstico Molecular, Análise Citogenética por Imagem e Nanotecnologia. O CIT tem por objetivo principal ser o elo entre o Instituto Evandro Chagas e diferentes setores da comunidade científica e da sociedade. A sua missão abrange o incentivo à inovação e proteção do conhecimento, geração de produtos, processos e serviços inovadores, e desenvolvimento técnico científico regional e nacional por meio de cooperações científicas e elaboração de projetos de P, D&I (Pesquisa, Desenvolvimento e Inovação).

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  • Near-complete genome of cosavirus A from a child hospitalized with acute gastroenteritis, Brazil 

    Lobo, Patrícia dos Santos; Cardoso, Jedson Ferreira; Barata, Rafael Ribeiro; Lemos, Poliana da Silva; Guerra, Sylvia de Fátima dos Santos; Soares, Luana da Silva; Nunes, Marcio Roberto Teixeira; Mascarenhas, Joana D’Arc Pereira (Elsevier, 2020)
    Acute gastroenteritis (AG) is responsible for 525,000 deaths worldwide in children under-5-years and is caused by the Human Cosavirus (HCoSV; family Picornaviridae, Genus Cosavirus). Although its health importance, a ...
  • Mitochondrial genome sequencing and phylogeny of Haemagogus albomaculatus, Haemagogus leucocelaenus, Haemagogus spegazzinii, and Haemagogus tropicalis (Diptera: Culicidae) 

    Silva, Fábio Silva da; Cruz, Ana Cecília Ribeiro; Medeiros, Daniele Barbosa de Almeida; Silva, Sandro Patroca da; Nunes, Márcio Roberto Teixeira; Martins, Lívia Carício; Chiang, Jannifer Oliveira; Lemos, Poliana da Silva; Cunha, Gabriel Muricy; Araujo, Renato Freitas de; Monteiro, Hamilton Antônio de Oliveira; Nunes Neto, Joaquim Pinto (Nature Research, 2020)
    The genus Haemagogus (Diptera: Culicidae) comprises species of great epidemiological relevance, involved in transmission cycles of the Yellow fever virus and other arboviruses in South America. So far, only Haemagogus ...
  • Human pegivirus (HPgV, GBV-C) RNA in volunteer blood donors from a public hemotherapy service in Northern Brazil 

    Silva, Aniel de Sarom Negrão; Lima, Clayton Pereira Silva de; Barata, Rafael Ribeiro; Silva, Pedro Victor Reis da; Monteiro, Patricia Danin Jordão; Lamarão, Letícia; Burbano, Rommel Mário Rodrígues; Nunes, Márcio Roberto Teixeira; Lima, Danielle Lima de (BMC, 2020)
    Human pegivirus (HPgV)—formerly known as GBV-C—is a member of the Flaviviridae family and belongs to the species Pegivirus C. It is a non-pathogenic virus and is transmitted among humans mainly through the exposure to ...
  • Insect-specific viruses and arboviruses in adult male culicids from Midwestern Brazil 

    Ferreira, Raquel da Silva; Cruz, Lucinéia Claudia de Toni Aquino da; Souza, Vilma Jucineide; Neves, Nilvanei Aparecido da Silva; Souza, Victor Costa de; Franco Filho, Luciano Chaves; Lemos, Poliana da Silva; Lima, Clayton Pereira Silva de; Naveca, Felipe Gomes; Atanaka, Marina; Nunes, Marcio Roberto Teixeira; Slhessarenko, Renata Dezengrini (Elsevier, 2020)
    Viruses were identified from male anthropophilic mosquitoes from Mato Grosso (MT) State, Midwest Brazil from February 2017 to January 2018. Mosquitoes tested included Aedes (Stegomyia) aegypti (1139 males; 84 pools), Culex ...
  • In silico improvement of the cyanobacterial lectin microvirin and mannose interaction 

    Lima, Adonis de Melo; Siqueira, Andrei Santos; Moller, Marina Luiza Saraiva; Souza, Rafael Conceição de; Cruz, Joddy Neves; Lima, Alex Ranieri Jerônimo; Silva, Ronaldo Correia da; Aguiar, Délia Cristina Figueira; Vianez Júnior, João Lídio da Silva Gonçalves; Gonçalves, Evonnildo Costa (Taylor & Francis, 2020)
    Lectins that bind to HIV envelope glycoprotein can inhibit virus-cell fusion and be used for rational drug design. This paper presents the results of anin silicoapproach to improve affinity interaction between the ...
  • 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales 

    Kuhn, Jens H; Adkins, Scott; Alioto, Daniela; Alkhovsky, Sergey V; Amarasinghe, Gaya K; Anthony, Simon J; Avsic-Zupanc, Tatjana; Ayllón, María A; Bahl, Justin; Balkema-Buschmann, Anne; Ballinger, Matthew J; Bartonicka, Tomás; Basler, Christopher; Bavari, Sina; Beer, Martin; Bente, Dennis A; Bergeron, Éric; Bird, Brian H; Blair, Carol; Blasdell, Kim R; Bradfute, Steven B; Breyta, Rachel; Briese, Thomas; Brown, Paul A; Buchholz, Ursula J; Buchmeier, Michael J; Bukreyev, Alexander; Burt, Felicity; Buzkan, Nihal; Calisher, Charles H; Cao, Menagji; Casas, Inmaculada; Chamberlain, John; Chandran, Kartik; Charrel, Rémi N; Chen, Biao; Chiumenti, Michela; Choi, II-Ryong; Clegg, J. Christopher S; Crozier, Ian; Graça, John V. da; Bó, Elena Dal; Dávila, Alberto M. R; La Torre, Juan Carlos de; Lamballerie, Xavier de; Swart, Rik L. de; Di Bello, Patrick L; Di Paola, Nicholas; Di Serio, Francesco; Dietzgen, Ralf G; Digiaro, Michele; Dolja, Valerian V; Dolnik, Olga; Drebot, Michael A; Drexler, Jan Felix; Durrwald, Ralf; Dufkova, Lucie; Dundon, William G; Duprex, W. Paul; Dye, John M; Easton, Andrew J; Edihara, Hideki; Elbeaino, Toufic; Ergunay, Koray; Fernandes, Jorlan; Fooks, Anthony R; Formenty, Pierre B. H; Forth, Leonie F; Fouchier, Ron A. M; Freitas-Astúa, Juliana; Gago-Zachert, Selma; Gao, George Fú; García, Maria Laura; García-Sastre, Adolfo; Garrison, Aura R; Gbakima, Aiah; Goldstein, Tracey; Gonzalez, Jean-Paul J; Griffiths, Anthony; Groschup, Martin H; Gunther, Stephan; Guterres, Alexandro; Hall, Roy A; Hammond, John; Hassan, Mohamed; Hepojoki, Jussi; Hepojoki, Satu; Hetzel, Udo; Hewson, Roger; Hoffmann, Bernd; Hongo, Seiji; Hoper, Dirk; Horie, Massayuki; Hughes, Holly R; Hyndman, Timothy H; Jambai, Amara; Jardim, Rodrigo; Jiãng, Dàohóng; Jin, Qi; Jonson, Gilda B; Junglen, Sandra; Karadag, Serpil; Keller, Karen E; Klempa, Boris; Klingstrom, Jonas; Kobinger, Gary; Kondõ, Hideki; Koonin, Eugene V; Krupovic, Mart; Kurath, Gael; Kuzmin, Ivan V; Laenen, Lies; Lamb, Robert A; Lambert, Amy J; Langevin, Stanley L; Lee, Benhur; Lemos, Elba R. S; Leroy, Eric M; Li, Dexin; Li, Jiànròng; Liang, Mifang; Liú, Wénwén; Liú, Yàn; Lukaxhevich, Igor S; Maes, Piet; Souza, William Marciel de; Marklewitz, Marco; Marshall, Sergio H; Martelli, Giovanni P; Martin, Robert R; Marzano, Shin-Yi L; Massart, Sébastien; McCauley, John W; Mielke-Ehret, Nicole; Minafra, Angelantonio; Minutolo, Maria; Mirazimi, Ali; Muhlbach, Hans-Peter; Muhlberger, Elke; Naidu, Rayapati; Natsuaki, Tomohide; Navarro, Beatriz; Navarro, José A; Netesov, Sergey V; Neumann, Gabriele; Nowotny, Nobert; Nunes, Márcio Roberto Teixeira; Nylund, Are; Okland, Arnfinn L; Oliveira, Renata C; Palacios, Gustavo; Pallas, Vicente; Pályi, Bernadett; Papa, Anna; Parrish, Colin R; Pauvolid-Corrêa, Alex; Paweska, Janusz T; Payne, Susan; Pérez, Daniel R; Pfaff, Florian; Radoshitzky, Sheli R; Rahman, Aziz-ul; Ramos-González, Pedro L; Resende, Renato O; Reyes, Carina A; Rima, Bertus K; Romanowski, Víctor; Luna, Gabriel Robles; Rota, Paul; Rubbenstroth, Dennis; Runstadler, Jonathan A; Ruzek, Daniel; Sabanadzovic, Sead; Salát, Jirí; Sall, Amadou Alpha; Salvato, Maria S; Sarpkaya, Kamil; Sasaya, Takahide; Schwemmle, Martin; Shabbir, Muhammad Z; Shí, Xiãohóng; Shí, Zhènglì; Shirako, Yukio; Simmonds, Peter; Sirmarová, Jana; Sironi, Manuela; Smither, Sophie; Smura, Teemu; Song, Jin-Wong; Spann, Kirsten M; Spengler, Jessica R; Stenglein, Mark D; Stone, David M; Straková, Petra; Takada, Ayato; Tesh, Robert B; Thornburg, Natalie J; Tomonaga, Keizõ; Tordo, Noel; Towner, Jonathan S; Turina, Massimo; Tzanetakis, Joannis; Ulrich, Rainer G; Vaira, Anna Maria; Van den Hoogen, Bernadette; Varsani, Arvind; Vasilakis, Nikos; Verbeek, Martin; Wahl, Victoria; Walker, Peter J; Wang, Hui; Wang, Jianwei; Wang, Xifeng; Wang, Lin-Fa; Wèi, Tàiyún; Wells, Heather; Whitfield, Anna E; Williams, John V; Wolf, Yuri I; Wú, Zhìqiáng; Yang, Xin; Yáng, Xinglóu; Yu, Xuejie; Yutin, Natalya; Zerbini, F. Murilo; Zhang, Tong; Zhang, Yong-Zhen; Zhou, Guohui; Zhou, Xueping (Springer Verlag, 2020)
    In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratifcation vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were ...
  • Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? 

    Almeida, Deise Cibele N. de; Souza, Michel Platini Caldas de; Amorim, Carolina Koury Nassar; Maués, Jersey Heitor da Silva; Sagica, Fernanda do Espirito Santo; Moreira-Nunes, Caroline Aquino; Oliveria, Edivaldo Herculano Corrêa de (International Institute of Anticancer Research, 2020)
    Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, ...
  • Evolutionary and molecular analysis of complete genome sequences of norovirus from Brazil: emerging recombinant strain GII.P16/GII.4 

    Hernandez, Juliana Merces; Silva, Luciana Damascena da; Sousa Júnior, Edivaldo Costa; Cardoso, Jedson Ferreira; Reymão, Tammy Kathlyn Amaral; Portela, Ana Caroline Rodrigues; Lima, Clayton Pereira Silva de; Teixeira, Dielle Monteiro; Lucena, Maria Silvia Souza; Nunes, Marcio Roberto Teixeira; Gabbay, Yvone Benchimol (Frontiers Media, 2020)
    Noroviruses (NoVs) are enteric viruses that cause acute gastroenteritis, and the pandemic GII.4 genotype is spreading and evolving rapidly. The recombinant GII.P16/GII.4_Sydney strain emerged in 2016, replacing ...
  • Immune escape mutations in HIV-1 controllers in the Brazilian Amazon region 

    Gomes, Samara Tatielle Monteiro; Amoras, Ednelza da Silva Graças; Gomes, Érica Ribeiro; Queiroz, Maria Alice Freitas; Sousa Júnior, Edivaldo Costa; Massafra, Janaína Mota de Vasconcelos; Lemos, Poliana da Silva; Vianez Júnior, João Lídio da Silva Gonçalves; Vallinoto, Antonio Carlos Rosário (BMC, 2020)
    Background: Human immunodeficiency virus (HIV-1) infection is characterized by high viral replication and a decrease in CD4+ T cells (CD4+TC), resulting in AIDS, which can lead to death. In elite controllers and viremia ...
  • Barrita Virus, a novel virus of the patois serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) 

    Fernández, Diana; Souza, William Marciel de; Silvas, Jesus A; Deardorff, Eleanor R; Widen, Steven G; Estrada-Franco, Jose G; Weaver, Scott C; Nunes, Marcio Roberto Teixeira; Aguilar, Patricia v (American Society of Tropical Medicine and Hygiene, 2020)
    During ecological investigations for arboviruses conducted in coastal Chiapas, Mexico, in 2007, isolate MP1078 was obtained from a pool of Psorophora varipes mosquitoes. Based on antigenic characterization, this isolate ...
  • Whole-genome sequencing of an unusual human papillomavirus (HPV71) from Latin America (Brazil) 

    Sousa Júnior, Edivaldo Costa; Silva, Allan Kaio; Reis, Laryssa Danielle da Silva; Fonseca, Lana Patricia da Silva; Silva, Fabiano Reis da; Santos, Fabiolla da Silva dos; Ferreira, Jessylene Almeida; Lima, Clayton Pereira Silva de; Abreu, Michelle Carvalho de; Silvestre, Rodrigo Vellasco Duarte; Nunes, Marcio Roberto Teixeira (American Society for Microbiology, 2020)
    We report the complete genome sequencing of human papillomavirus 71 from Latin America (Brazil).
  • Using accelerated molecular dynamics simulation to elucidate the effects of the T198F mutation on the molecular flexibility of the West Nile virus envelope protein 

    Valente, Renan Patrick de Penha; Souza, Rafael Conceição de; Muniz, Gabriela de Medeiros; Ferreira, João Elias Vidueira; Miranda, Ricardo Morais de; Lima, Anderson Henrique Lima e; Vianez Júnior, João Lídio da Silva Gonçalves (Nature Research, 2020)
    The envelope (E) protein is an important target for antibodies in favivirus. Literature reports that the mutation T198F, located at the domain I-II hinge of the E protein, regulates viral breathing and increases the ...
  • Metallothionein expression and its influence on the in vitro biological behavior of mucoepidermoid carcinoma 

    Aquime, João Rafael Habib souza; Zampieri, Lara Carolina D'Araújo Pinto; Kataoka, MAria Sueli da Silva; Ribeiro, Nelson Antonio Bailão; Jaeger, Ruy Gastaldoni; Silva, Artur Luiz da; Ramos, Rommel Thiago Jucá; Alves Júnior, Sérgio de Melo; Pinheiro, João de Jesus Viana (MDPI, 2020)
    Mucoepidermoid carcinoma (MEC) is the most common tumor in the salivary glands, often presenting with recurrence and metastasis due to its high invasive capacity. Metallothionein (MT), a zinc storage protein that supplies ...
  • Evolutionary dynamics of Oropouche virus in South America 

    Gutierrez, Bernardo; Wise, Emma L; Pullan, Steven T; Logue, Christopher H; Bowden, Thomas A; Escalera-Zamudio, Marina; Trueba, Gabriel; Nunes, Marcio Roberto Teixeira; Faria, Nuno Rodrigues; Pybus, Oliver G (American Society for Microbiology, 2020)
    The Amazon basin is home to numerous arthropod-borne viral pathogens that cause febrile disease in humans. Among these, Oropouche orthobunyavirus (OROV) is a relatively understudied member of the genus Orthobunyavirus, ...
  • High genomic variability in equine infectious anemia virus obtained from naturally infected horses in Pantanal, Brazil: an endemic region case 

    Malossi, Camila Dantas; Fioratti, Eduardo Gorzoni; Cardoso, Jedson Ferreira; Magro, Angelo José; Kroon, Erna Geessien; Aguiar, Daniel Moura de; Borges, Alice Mamede Costa Marques; Nogueira, Marcia Furlan; Ullmann, Leila Sabrina; Araujo Jr, João Pessoa (MDPI, 2020)
    Abstract: Equine infectious anemia virus (EIAV) is a persistent lentivirus that causes equine infectious anemia (EIA). In Brazil, EIAV is endemic in the Pantanal region, and euthanasia is not mandatory in this area. All ...
  • Genomic and epidemiological surveillance of Zika virus in the Amazon region 

    Giovanetti, Marta; Faria, Nuno Rodrigues; Lourenço, José; Jesus, Jaqueline Goes de; Xavier, Joilson; Claro, Ingra Morales; Kraemer, Moritz U. G; Fonseca, Vagner; Dellicour, Simon; Théze, Julien; Salles, Flavia da Silva; Graf, Tiago; Silveira, Paola Paz; Nascimento, Valdinete Alves do; Souza, Victor Costa de; Iani, Felipe Campos de Melo; Castilho-Martins, Emerson Augusto; Cruz, Laura Nogueira; Wallau, Gabriel; Fabri, Allison; Levy, Flávia; Quick, Joshua; Azevedo, Vasco de; Aguiar, Renato Santana; Oliveira, Tulio de; Menezes, Camila Bôtto de; Castilho, Marcia da Costa; Terra, Tirza Matos; Silva, Marineide Souza da; Filippis, Ana Maria Bispo de; Abreu, André Luiz de; Oliveira, Wanderson Kleber; Croda, Julio; Albuquerque, Carlos F. Campelo de; Nunes, Marcio Roberto Teixeira; Sabino, Ester Cerdeira; Loman, Nicholas; Naveca, Felipe Gomes; Pybus, Oliver G; Alcantara, Luiz Carlos (Elsevier, 2020)
    Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, ...
  • ICTV virus taxonomy profile: Peribunyaviridae 

    Hughes, Holly R; Adkins, Scott; Alkhovskiy, Sergey; Beer, Martin; Blair, Carol; Calisher, Charles H; Drebot, Mike; Lambert, Amy J; Souza, William Marciel de; Marklewitz, Marco; Nunes, Márcio Roberto Teixeira; Shi, Xiãohóng (Microbiology Society, 2020)
    Peribunyaviruses are enveloped and possess three distinct, single-stranded, negative-sense RNA segments comprising 11.2–12.5kb in total. The family includes globally distributed viruses in the genera Orthobunyavirus, ...
  • Congenital Zika syndrome is associated with maternal protein malnutrition 

    Barbeito-Andrés, J; Pezzuto, P; Higa, L. M; Dias, A. A; Vasconcelos, J. M; Santos, T. M. P; Ferreira, J. C. C. G; Ferreira, R. O; Dutra, F. F; Rossi, A. D; Barbosa, R. V; Amorim, C. K. N; Souza, M. P. C de; Chimelli, L; Aguiar, R. S; Gonzalez, P. N; Lara, F. A; Castro, M. C; Molnár, Z; Lopes, R. T; Bozza, M. T; Vianez Júnior, João Lídio da Silva Gonçalves; Barbeito, C. G; Cuervo, P; Bellio, M; Tanuri, A; Garcez, P. P (American Association for the Advancement of Science, 2020)
    Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, ...
  • Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil 

    Torres, Maria K. S; Avelino, Maria E. S; Irias, Susan F; Barbosa, Mike S; Pereira, Danilo L. A; Lima, Ana B. F; Lemos, Poliana da Silva; Lima, Clayton Pereira Silva de; Oliveira, Renato R. M; Frânces, Regiane S. K; Vianez Júnior, João Lídio da Silva Gonçalves; Machado, Luiz Fernando Almeida (Mary Ann Liebert, 2020)
    We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Belém, Pará, Amazon region of Brazil. The partial integrase gene ...
  • Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis 

    Araújo, Thessika Hialla Almeida; Barreto, Fernanda Khouri; Menezes, Aline Dórea Luz; Lima, Clayton Pereira Silva de; Oliveira, Rodrigo Santos de; Lemos, Poliana da Silva; Galvão-Castro, Bernardo; Kashima, Simone; Farre, Lourdes; Bittencourt, Achilea Lisboa; Carvalho, Edgar Marcelino de; Santos, Luciane Amorim; Rego, Filipe Ferreira de Almeida; Mota-Miranda, Aline Cristina Andrade; Nunes, Márcio Roberto Teixeira; Alcântara, Luiz Carlos Júnior (Elsevier, 2020)
    The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete ...

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