CENTRO DE INOVAÇÕES TECNOLÓGICAS: Recent submissions
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Differential expression analysis and profiling of hepatic miRNA and isomiRNA in dengue hemorrhagic fever
(Scientific Reports, 2021)Dengue virus causes dengue hemorrhagic fever (DHF) and has been associated to fatal cases worldwide. The liver is one of the most important target tissues in severe cases, due to its intense viral replication and metabolic ... -
Incidence of viral hepatitis in brazil from 2009 to 2018: an epidemiological study of confirmed cases of viral hepatitis
(Sociedade Brasileira de Medicina Tropical, 2021)INTRODUCTION: Viral hepatitis is a major public health problem. It is necessary to understand the epidemic, verifying the combination of biological and demographic characteristics. METHODS: This is an analytical ecological ... -
Isolation and genetic identification of endophytic lactic acid bacteria from the Amazonian Açai fruits: probiotics features of selected strains and their potential to inhibit pathogens
(Frontiers Media, 2021)The açai palm (Euterpe oleracea) is native to the Amazon basin, a humid tropical forest. High levels of total mesophilic bacteria with high diversity have been consistently reported in açai fruits. As local consumers have ... -
Evaluation of drug susceptibility profile of mycobacterium tuberculosis lineage 1 from brazil based on whole genome sequencing and phenotypic methods
(Instituto Oswaldo Cruz, 2020)BACKGROUND The evaluation of procedures for drug susceptibility prediction of Mycobacterium tuberculosis based on genomic data against the conventional reference method test based on culture is realistic considering the ... -
Near-complete genome of cosavirus A from a child hospitalized with acute gastroenteritis, Brazil
(Elsevier, 2020)Acute gastroenteritis (AG) is responsible for 525,000 deaths worldwide in children under-5-years and is caused by the Human Cosavirus (HCoSV; family Picornaviridae, Genus Cosavirus). Although its health importance, a ... -
Mitochondrial genome sequencing and phylogeny of Haemagogus albomaculatus, Haemagogus leucocelaenus, Haemagogus spegazzinii, and Haemagogus tropicalis (Diptera: Culicidae)
(Nature Research, 2020)The genus Haemagogus (Diptera: Culicidae) comprises species of great epidemiological relevance, involved in transmission cycles of the Yellow fever virus and other arboviruses in South America. So far, only Haemagogus ... -
Human pegivirus (HPgV, GBV-C) RNA in volunteer blood donors from a public hemotherapy service in Northern Brazil
(BMC, 2020)Human pegivirus (HPgV)—formerly known as GBV-C—is a member of the Flaviviridae family and belongs to the species Pegivirus C. It is a non-pathogenic virus and is transmitted among humans mainly through the exposure to ... -
Insect-specific viruses and arboviruses in adult male culicids from Midwestern Brazil
(Elsevier, 2020)Viruses were identified from male anthropophilic mosquitoes from Mato Grosso (MT) State, Midwest Brazil from February 2017 to January 2018. Mosquitoes tested included Aedes (Stegomyia) aegypti (1139 males; 84 pools), Culex ... -
In silico improvement of the cyanobacterial lectin microvirin and mannose interaction
(Taylor & Francis, 2020)Lectins that bind to HIV envelope glycoprotein can inhibit virus-cell fusion and be used for rational drug design. This paper presents the results of anin silicoapproach to improve affinity interaction between the ... -
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
(Springer Verlag, 2020)In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratifcation vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were ... -
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
(International Institute of Anticancer Research, 2020)Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, ... -
Evolutionary and molecular analysis of complete genome sequences of norovirus from Brazil: emerging recombinant strain GII.P16/GII.4
(Frontiers Media, 2020)Noroviruses (NoVs) are enteric viruses that cause acute gastroenteritis, and the pandemic GII.4 genotype is spreading and evolving rapidly. The recombinant GII.P16/GII.4_Sydney strain emerged in 2016, replacing ... -
Immune escape mutations in HIV-1 controllers in the Brazilian Amazon region
(BMC, 2020)Background: Human immunodeficiency virus (HIV-1) infection is characterized by high viral replication and a decrease in CD4+ T cells (CD4+TC), resulting in AIDS, which can lead to death. In elite controllers and viremia ... -
Barrita Virus, a novel virus of the patois serogroup (Genus Orthobunyavirus; Family Peribunyaviridae)
(American Society of Tropical Medicine and Hygiene, 2020)During ecological investigations for arboviruses conducted in coastal Chiapas, Mexico, in 2007, isolate MP1078 was obtained from a pool of Psorophora varipes mosquitoes. Based on antigenic characterization, this isolate ... -
Whole-genome sequencing of an unusual human papillomavirus (HPV71) from Latin America (Brazil)
(American Society for Microbiology, 2020)We report the complete genome sequencing of human papillomavirus 71 from Latin America (Brazil). -
Using accelerated molecular dynamics simulation to elucidate the effects of the T198F mutation on the molecular flexibility of the West Nile virus envelope protein
(Nature Research, 2020)The envelope (E) protein is an important target for antibodies in favivirus. Literature reports that the mutation T198F, located at the domain I-II hinge of the E protein, regulates viral breathing and increases the ... -
Metallothionein expression and its influence on the in vitro biological behavior of mucoepidermoid carcinoma
(MDPI, 2020)Mucoepidermoid carcinoma (MEC) is the most common tumor in the salivary glands, often presenting with recurrence and metastasis due to its high invasive capacity. Metallothionein (MT), a zinc storage protein that supplies ... -
Evolutionary dynamics of Oropouche virus in South America
(American Society for Microbiology, 2020)The Amazon basin is home to numerous arthropod-borne viral pathogens that cause febrile disease in humans. Among these, Oropouche orthobunyavirus (OROV) is a relatively understudied member of the genus Orthobunyavirus, ... -
High genomic variability in equine infectious anemia virus obtained from naturally infected horses in Pantanal, Brazil: an endemic region case
(MDPI, 2020)Abstract: Equine infectious anemia virus (EIAV) is a persistent lentivirus that causes equine infectious anemia (EIA). In Brazil, EIAV is endemic in the Pantanal region, and euthanasia is not mandatory in this area. All ... -
Genomic and epidemiological surveillance of Zika virus in the Amazon region
(Elsevier, 2020)Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, ...