CIT - Artigos Científicos
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Os documentos disponíveis no repositório são de propriedade e responsabilidade de seus autores, conforme a legislação que rege o direito autoral no país (Lei nº 9.610 , de 19.02.98).
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Unwanted exacerbation of the immune response in neurodegenerative disease: a time to review the impact
(Frontiers Media, 2021)The COVID-19 pandemic imposed a series of behavioral changes that resulted in increased social isolation and a more sedentary life for many across all age groups, but, above all, for the elderly population who are the most ... -
Fatal outcome of chikungunya virus infection in Brazil
(Oxford University Press, 2021)BACKGROUND: Chikungunya virus (CHIKV) emerged in the Americas in 2013 and has caused approximately 2.1 million cases and >600 deaths. A retrospective investigation was undertaken to describe clinical, epidemiological, and ... -
2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
(Springer, 2021)In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families ... -
Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism
(Elsevier, 2021)Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular ... -
Sialovirome of Brazilian tropical anophelines
(Elsevier, 2021)Anophelinae is a widely dispersed Culicidae subfamily that may carry a unique virome. Here we herein report the set of viruses found in 323 salivary glands of 16 anopheline species sampled at Upper Pantanal, Chapada dos ... -
Analysis of kojic acid derivatives as competitive inhibitors of tyrosinase: a molecular modeling approach
(MDPI, 2021)Abstract: Tyrosinases belong to the functional copper-containing proteins family, and their structure contains two copper atoms, in the active site, which are coordinated by three histidine residues. The biosynthesis of ... -
Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil
(Nature Research, 2021)Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom ... -
Differential expression analysis and profiling of hepatic miRNA and isomiRNA in dengue hemorrhagic fever
(Scientific Reports, 2021)Dengue virus causes dengue hemorrhagic fever (DHF) and has been associated to fatal cases worldwide. The liver is one of the most important target tissues in severe cases, due to its intense viral replication and metabolic ... -
Incidence of viral hepatitis in brazil from 2009 to 2018: an epidemiological study of confirmed cases of viral hepatitis
(Sociedade Brasileira de Medicina Tropical, 2021)INTRODUCTION: Viral hepatitis is a major public health problem. It is necessary to understand the epidemic, verifying the combination of biological and demographic characteristics. METHODS: This is an analytical ecological ... -
Isolation and genetic identification of endophytic lactic acid bacteria from the Amazonian Açai fruits: probiotics features of selected strains and their potential to inhibit pathogens
(Frontiers Media, 2021)The açai palm (Euterpe oleracea) is native to the Amazon basin, a humid tropical forest. High levels of total mesophilic bacteria with high diversity have been consistently reported in açai fruits. As local consumers have ... -
Evaluation of drug susceptibility profile of mycobacterium tuberculosis lineage 1 from brazil based on whole genome sequencing and phenotypic methods
(Instituto Oswaldo Cruz, 2020)BACKGROUND The evaluation of procedures for drug susceptibility prediction of Mycobacterium tuberculosis based on genomic data against the conventional reference method test based on culture is realistic considering the ... -
Near-complete genome of cosavirus A from a child hospitalized with acute gastroenteritis, Brazil
(Elsevier, 2020)Acute gastroenteritis (AG) is responsible for 525,000 deaths worldwide in children under-5-years and is caused by the Human Cosavirus (HCoSV; family Picornaviridae, Genus Cosavirus). Although its health importance, a ... -
Mitochondrial genome sequencing and phylogeny of Haemagogus albomaculatus, Haemagogus leucocelaenus, Haemagogus spegazzinii, and Haemagogus tropicalis (Diptera: Culicidae)
(Nature Research, 2020)The genus Haemagogus (Diptera: Culicidae) comprises species of great epidemiological relevance, involved in transmission cycles of the Yellow fever virus and other arboviruses in South America. So far, only Haemagogus ... -
Human pegivirus (HPgV, GBV-C) RNA in volunteer blood donors from a public hemotherapy service in Northern Brazil
(BMC, 2020)Human pegivirus (HPgV)—formerly known as GBV-C—is a member of the Flaviviridae family and belongs to the species Pegivirus C. It is a non-pathogenic virus and is transmitted among humans mainly through the exposure to ... -
Insect-specific viruses and arboviruses in adult male culicids from Midwestern Brazil
(Elsevier, 2020)Viruses were identified from male anthropophilic mosquitoes from Mato Grosso (MT) State, Midwest Brazil from February 2017 to January 2018. Mosquitoes tested included Aedes (Stegomyia) aegypti (1139 males; 84 pools), Culex ... -
In silico improvement of the cyanobacterial lectin microvirin and mannose interaction
(Taylor & Francis, 2020)Lectins that bind to HIV envelope glycoprotein can inhibit virus-cell fusion and be used for rational drug design. This paper presents the results of anin silicoapproach to improve affinity interaction between the ... -
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
(Springer Verlag, 2020)In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratifcation vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were ... -
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
(International Institute of Anticancer Research, 2020)Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, ... -
Evolutionary and molecular analysis of complete genome sequences of norovirus from Brazil: emerging recombinant strain GII.P16/GII.4
(Frontiers Media, 2020)Noroviruses (NoVs) are enteric viruses that cause acute gastroenteritis, and the pandemic GII.4 genotype is spreading and evolving rapidly. The recombinant GII.P16/GII.4_Sydney strain emerged in 2016, replacing ... -
Immune escape mutations in HIV-1 controllers in the Brazilian Amazon region
(BMC, 2020)Background: Human immunodeficiency virus (HIV-1) infection is characterized by high viral replication and a decrease in CD4+ T cells (CD4+TC), resulting in AIDS, which can lead to death. In elite controllers and viremia ...