Anti-promastigote activity of the amazon plants

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2017xmlui.dri2xhtml.METS-1.0.item-files-viewOpen
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http://patua.iec.gov.br//handle/iec/3692xmlui.dri2xhtml.METS-1.0.item-author
Silva-Silva, João Victor
Monteiro, R. C. S.
Brígido, Helliton Patrick Cordovil
Vale, Valdicley Vieira
Silvestre, J. V.
Silva, N. C. S.
Silveira, Fernando Tobias
Marinho, A. M. R.
Dolabela, Maria Fâni
xmlui.dri2xhtml.METS-1.0.item-abstract
This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against
promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was
evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus
articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata.
The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of
steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.
xmlui.dri2xhtml.METS-1.0.item-citation
SILVA-SILVA, João Victor et al. Anti-promastigote activity of the amazon plants. Journal of Pharmacy and Pharmacology, v. 5, n. 9, p. 654-660, Sept. 2017.xmlui.dri2xhtml.METS-1.0.item-decsPrimary
Fitoterapia / métodosPlantas Medicinais / química
Extratos Vegetais / química
Leishmania / efeitos dos fármacos
Himatanthus articulatus
Fasciculata parahancornia
Montrichardia linifera
Physalis angulata