Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
Carvalho, Leonardo José de Moura
Oliveira, S. G.
Alves, Francisco Acácio
Andrade, M. C. R.
Zanini, G. M.
Brígido, Maria do Carmo de Oliveira
Póvoa, Marinete Marins
Muniz, José Augusto Pereira Carneiro
Daniel-Ribeiro, Cláudio Tadeu
The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens.
ReferenciaCARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, Apr. 2004.
DeCsSaimiri / imunologia
Plasmodium falciparum / imunologia
Antígenos de Protozoários
Anticorpos Antiprotozoários / análise